Initiation of in vitro reverse transcription from tRNA(Lys3) on HIV-1 or HIV-2 RNAs by both type 1 and 2 reverse transcriptases

HIV reverse transcription is initiated from a cellular tRNA partially associated with the retroviral genome. Here we studied homologous HIV-2 cDNA synthesis using natural or synthetic primers. With natural tRNA(Lys3), synthesis of early products comprising nucleotides +5 to +7 preceded the elongatio...

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Veröffentlicht in:	FEBS letters 1998-07, Vol.430 (3), p.165-170
Hauptverfasser:	Boulmé, F, Freund, F, Litvak, S
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Base Sequence DNA Primers DNA, Complementary - biosynthesis HIV Reverse Transcriptase - metabolism HIV-1 - genetics HIV-2 - genetics Humans Molecular Sequence Data RNA RNA, Transfer, Amino Acyl - genetics RNA, Viral - genetics RNA-Directed DNA Polymerase - metabolism Transcription, Genetic - genetics
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