Expression and Initial Characterization of a Soluble Glycine Binding Domain of the N-Methyl-d-aspartate Receptor NR1 Subunit

Glycine is an essential co-agonist of the excitatory N-methyl-d-aspartate (NMDA) receptor, a subtype of the ionotropic glutamate receptor family. The glycine binding site of this hetero-oligomeric ion channel protein is formed by two distinct extracellular regions, S1 and S2, of the NR1 subunit, whe...

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