Interaction Mode of the Phe-Phenyl Group of Thrombin Receptor-Tethered Ligand SFLLRNP in Receptor Activation

Phenylalanine at position 2 of thrombin receptor-tethered ligand peptide (SFLLRNP) is crucially important for the activation of thrombin receptor. Its substitution by para-fluorophenylalanine [(p-F)Phe] enhanced several times the activity in human epithelial-like SH-EP cells [Nose et al. (1993) Bioc...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 1998-08, Vol.124 (2), p.354-358
Hauptverfasser:	Nose, Takeru, Fujita, Tsugumi, Nakajima, Masahide, Inoue, Yoshihisa, Costa, Tommaso, Shimohigashi, Yasuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Humans Ligands Molecular Sequence Data p-Fluorophenylalanine - metabolism para-fluorophenylalanine Peptide Fragments - metabolism Phenylalanine - metabolism Platelet Aggregation - drug effects receptor recognition Receptors, Thrombin - drug effects Receptors, Thrombin - metabolism Structure-Activity Relationship tethered ligand peptide thrombin Thrombin - chemistry Thrombin - metabolism thrombin receptor
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