mRNA expression patterns of the IGF system during mouse limb bud development, determined by whole mount in situ hybridization

During limb development the primary limb bud requires various signals to differentiate. Insulin-like growth factor (IGF)-I and IGF-II serve as ubiquitous cellular growth promoters and are modulated by their binding proteins (IGFBPs), which inhibit or augment IGF bioavailability. This is the first st...

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Veröffentlicht in:	Molecular and cellular endocrinology 1998-03, Vol.138 (1), p.151-161
Hauptverfasser:	van Kleffens, Marjolein, Groffen, Cora, Rosato, Roberto R., van den Eijnde, Stefan M., van Neck, Johan W., Lindenbergh-Kortleve, Dicky J., Zwarthoff, Ellen C., Drop, Stenvert L.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cartilage, Articular - embryology Cell Differentiation Development Embryonic and Fetal Development Female Fluorescent Dyes Gene Expression Regulation, Developmental IGF IGFBPs In Situ Hybridization Insulin-Like Growth Factor Binding Proteins - genetics Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor II - genetics Joints - embryology Limb Limb Buds - physiology Mice Mice, Inbred BALB C Oxazines Pregnancy Receptor, IGF Type 1 - genetics RNA Probes RNA, Messenger - biosynthesis RNA, Messenger - genetics Transcription, Genetic Whole mount in situ hybridization
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