Xenin—a novel suppressor of food intake in rats
Peptides related to the amphibian octapeptide xenopsin are present in various locations in mammalians, such as the gastrointestinal mucosa or brain tissue. In the gastrointestinal tract, xenopsin-related peptides induce partially neurogenic contractions of the colon in humans. In brain, however, the...
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| Veröffentlicht in: | Brain research 1998-08, Vol.800 (2), p.294-299 |
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| description | Peptides related to the amphibian octapeptide xenopsin are present in various locations in mammalians, such as the gastrointestinal mucosa or brain tissue. In the gastrointestinal tract, xenopsin-related peptides induce partially neurogenic contractions of the colon in humans. In brain, however, their function is not known. Structural similarities of xenopsin-related peptides with neurotensin, a known modulator of ingestive behavior, suggest a possible role in feeding regulation. Therefore, we examined the effect of xenin, a recently identified xenopsin-related pentacosa peptide, on feeding behavior of fasted rats. Male Wistar rats (
n=12) were intracerebroventricularly (i.c.v.) injected with either saline (10 μl) or xenin at 0.5, 1.5, 5 or 15 μg dissolved in an identical volume of 10 μl, respectively. In further experiments, xenin 15 μg/0.5 μl or 0.5 μl saline were injected into the lateral hypothalamus (LH). After injections, food intake (g), percentage of time spent with feeding (%) and prandial water intake (ml) were subsequently recorded for 2 h. After i.c.v. injection of 15 μg of xenin 1-h food intake was significantly reduced by 42% and 2-h food intake was diminished by 25%, respectively, compared to saline injection (
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| doi_str_mv | 10.1016/S0006-8993(98)00535-6 |
| format | Article |
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n=12) were intracerebroventricularly (i.c.v.) injected with either saline (10 μl) or xenin at 0.5, 1.5, 5 or 15 μg dissolved in an identical volume of 10 μl, respectively. In further experiments, xenin 15 μg/0.5 μl or 0.5 μl saline were injected into the lateral hypothalamus (LH). After injections, food intake (g), percentage of time spent with feeding (%) and prandial water intake (ml) were subsequently recorded for 2 h. After i.c.v. injection of 15 μg of xenin 1-h food intake was significantly reduced by 42% and 2-h food intake was diminished by 25%, respectively, compared to saline injection (
p<0.01). This reduction of food intake was paralleled by a significant decrease of time spent with feeding by 41% (after 1 h) or 23% (after 2 h). The xenin-induced suppression of feeding behavior was dose-dependent. Thus, the minimal effective dose of xenin was 1.5 μg, while the dose of 0.5 μg was ineffective. Prandial water intake was significantly reduced only by the highest dose of xenin. Following injection of 15 μg of xenin into the lateral hypothalamus food intake was not different from control experiments. These data demonstrate a potent feeding suppressive action of xenin following intracerebroventricularly injection but not injection into the lateral hypothalamus suggesting a possible role of xenin in the central control of feeding termination and satiety.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(98)00535-6</identifier><identifier>PMID: 9685684</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Animals ; Biological and medical sciences ; Eating - drug effects ; Fasting ; Feeding behavior ; Feeding Behavior - drug effects ; Feeding. Feeding behavior ; Food intake ; Fundamental and applied biological sciences. Psychology ; Gastrointestinal Hormones - chemistry ; Gastrointestinal Hormones - pharmacology ; Hypothalamic injection ; Hypothalamus - drug effects ; Hypothalamus - physiology ; Injections, Intraventricular ; Intracerebroventricular injection ; Male ; Microinjections ; Molecular Sequence Data ; Neurotensin - chemistry ; Oligopeptides - chemistry ; Peptides - chemistry ; Peptides - pharmacology ; Rats ; Rats, Wistar ; Satiation - drug effects ; Satiety ; Sodium Chloride - pharmacology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Xenin ; Xenopus Proteins</subject><ispartof>Brain research, 1998-08, Vol.800 (2), p.294-299</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1998 INIST-CNRS</rights><rights>Copyright 1998 Elsevier Science B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-74070889c516a526fbcc3b6ebe1c4abe461372fc68463dc764f53a7d912a2b623</citedby><cites>FETCH-LOGICAL-c472t-74070889c516a526fbcc3b6ebe1c4abe461372fc68463dc764f53a7d912a2b623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899398005356$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2345687$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9685684$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alexiou, Ch</creatorcontrib><creatorcontrib>Zimmermann, J.P</creatorcontrib><creatorcontrib>Schick, R.R</creatorcontrib><creatorcontrib>Schusdziarra, V</creatorcontrib><title>Xenin—a novel suppressor of food intake in rats</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Peptides related to the amphibian octapeptide xenopsin are present in various locations in mammalians, such as the gastrointestinal mucosa or brain tissue. In the gastrointestinal tract, xenopsin-related peptides induce partially neurogenic contractions of the colon in humans. In brain, however, their function is not known. Structural similarities of xenopsin-related peptides with neurotensin, a known modulator of ingestive behavior, suggest a possible role in feeding regulation. Therefore, we examined the effect of xenin, a recently identified xenopsin-related pentacosa peptide, on feeding behavior of fasted rats. Male Wistar rats (
n=12) were intracerebroventricularly (i.c.v.) injected with either saline (10 μl) or xenin at 0.5, 1.5, 5 or 15 μg dissolved in an identical volume of 10 μl, respectively. In further experiments, xenin 15 μg/0.5 μl or 0.5 μl saline were injected into the lateral hypothalamus (LH). After injections, food intake (g), percentage of time spent with feeding (%) and prandial water intake (ml) were subsequently recorded for 2 h. After i.c.v. injection of 15 μg of xenin 1-h food intake was significantly reduced by 42% and 2-h food intake was diminished by 25%, respectively, compared to saline injection (
p<0.01). This reduction of food intake was paralleled by a significant decrease of time spent with feeding by 41% (after 1 h) or 23% (after 2 h). The xenin-induced suppression of feeding behavior was dose-dependent. Thus, the minimal effective dose of xenin was 1.5 μg, while the dose of 0.5 μg was ineffective. Prandial water intake was significantly reduced only by the highest dose of xenin. Following injection of 15 μg of xenin into the lateral hypothalamus food intake was not different from control experiments. These data demonstrate a potent feeding suppressive action of xenin following intracerebroventricularly injection but not injection into the lateral hypothalamus suggesting a possible role of xenin in the central control of feeding termination and satiety.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Eating - drug effects</subject><subject>Fasting</subject><subject>Feeding behavior</subject><subject>Feeding Behavior - drug effects</subject><subject>Feeding. Feeding behavior</subject><subject>Food intake</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrointestinal Hormones - chemistry</subject><subject>Gastrointestinal Hormones - pharmacology</subject><subject>Hypothalamic injection</subject><subject>Hypothalamus - drug effects</subject><subject>Hypothalamus - physiology</subject><subject>Injections, Intraventricular</subject><subject>Intracerebroventricular injection</subject><subject>Male</subject><subject>Microinjections</subject><subject>Molecular Sequence Data</subject><subject>Neurotensin - chemistry</subject><subject>Oligopeptides - chemistry</subject><subject>Peptides - chemistry</subject><subject>Peptides - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Satiation - drug effects</subject><subject>Satiety</subject><subject>Sodium Chloride - pharmacology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Xenin</subject><subject>Xenopus Proteins</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1KAzEQx4MotX48QmEPInpYzXeyJ5HiFwgeVPAWstlZiG43NdkWvPkQPqFPYrSlV0_DML-Z-fNDaELwGcFEnj9ijGWpq4qdVPoUY8FEKbfQmGhFS0k53kbjDbKL9lJ6zS1jFR6hUSW1kJqPEXmB3vffn1-26MMSuiIt5vMIKYVYhLZoQ2gK3w_2DXIpoh3SAdppbZfgcF330fP11dP0trx_uLmbXt6Xjis6lIpjhbWunCDSCirb2jlWS6iBOG5r4JIwRVuXU0jWOCV5K5hVTUWopbWkbB8dr-7OY3hfQBrMzCcHXWd7CItkNMacMqH_BYkUmAvFMyhWoIshpQitmUc_s_HDEGx-nZo_p-ZXmKm0-XNqZN6brB8s6hk0m621xDw_Ws9tcrZro-2dTxuMMp4xlbGLFQbZ2tJDNMl56B00PoIbTBP8P0F-AA5ykhI</recordid><startdate>19980803</startdate><enddate>19980803</enddate><creator>Alexiou, Ch</creator><creator>Zimmermann, J.P</creator><creator>Schick, R.R</creator><creator>Schusdziarra, V</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19980803</creationdate><title>Xenin—a novel suppressor of food intake in rats</title><author>Alexiou, Ch ; Zimmermann, J.P ; Schick, R.R ; Schusdziarra, V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-74070889c516a526fbcc3b6ebe1c4abe461372fc68463dc764f53a7d912a2b623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Eating - drug effects</topic><topic>Fasting</topic><topic>Feeding behavior</topic><topic>Feeding Behavior - drug effects</topic><topic>Feeding. Feeding behavior</topic><topic>Food intake</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastrointestinal Hormones - chemistry</topic><topic>Gastrointestinal Hormones - pharmacology</topic><topic>Hypothalamic injection</topic><topic>Hypothalamus - drug effects</topic><topic>Hypothalamus - physiology</topic><topic>Injections, Intraventricular</topic><topic>Intracerebroventricular injection</topic><topic>Male</topic><topic>Microinjections</topic><topic>Molecular Sequence Data</topic><topic>Neurotensin - chemistry</topic><topic>Oligopeptides - chemistry</topic><topic>Peptides - chemistry</topic><topic>Peptides - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Satiation - drug effects</topic><topic>Satiety</topic><topic>Sodium Chloride - pharmacology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Xenin</topic><topic>Xenopus Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alexiou, Ch</creatorcontrib><creatorcontrib>Zimmermann, J.P</creatorcontrib><creatorcontrib>Schick, R.R</creatorcontrib><creatorcontrib>Schusdziarra, V</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alexiou, Ch</au><au>Zimmermann, J.P</au><au>Schick, R.R</au><au>Schusdziarra, V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Xenin—a novel suppressor of food intake in rats</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1998-08-03</date><risdate>1998</risdate><volume>800</volume><issue>2</issue><spage>294</spage><epage>299</epage><pages>294-299</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Peptides related to the amphibian octapeptide xenopsin are present in various locations in mammalians, such as the gastrointestinal mucosa or brain tissue. In the gastrointestinal tract, xenopsin-related peptides induce partially neurogenic contractions of the colon in humans. In brain, however, their function is not known. Structural similarities of xenopsin-related peptides with neurotensin, a known modulator of ingestive behavior, suggest a possible role in feeding regulation. Therefore, we examined the effect of xenin, a recently identified xenopsin-related pentacosa peptide, on feeding behavior of fasted rats. Male Wistar rats (
n=12) were intracerebroventricularly (i.c.v.) injected with either saline (10 μl) or xenin at 0.5, 1.5, 5 or 15 μg dissolved in an identical volume of 10 μl, respectively. In further experiments, xenin 15 μg/0.5 μl or 0.5 μl saline were injected into the lateral hypothalamus (LH). After injections, food intake (g), percentage of time spent with feeding (%) and prandial water intake (ml) were subsequently recorded for 2 h. After i.c.v. injection of 15 μg of xenin 1-h food intake was significantly reduced by 42% and 2-h food intake was diminished by 25%, respectively, compared to saline injection (
p<0.01). This reduction of food intake was paralleled by a significant decrease of time spent with feeding by 41% (after 1 h) or 23% (after 2 h). The xenin-induced suppression of feeding behavior was dose-dependent. Thus, the minimal effective dose of xenin was 1.5 μg, while the dose of 0.5 μg was ineffective. Prandial water intake was significantly reduced only by the highest dose of xenin. Following injection of 15 μg of xenin into the lateral hypothalamus food intake was not different from control experiments. These data demonstrate a potent feeding suppressive action of xenin following intracerebroventricularly injection but not injection into the lateral hypothalamus suggesting a possible role of xenin in the central control of feeding termination and satiety.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>9685684</pmid><doi>10.1016/S0006-8993(98)00535-6</doi><tpages>6</tpages></addata></record> |
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| subjects | Amino Acid Sequence Animals Biological and medical sciences Eating - drug effects Fasting Feeding behavior Feeding Behavior - drug effects Feeding. Feeding behavior Food intake Fundamental and applied biological sciences. Psychology Gastrointestinal Hormones - chemistry Gastrointestinal Hormones - pharmacology Hypothalamic injection Hypothalamus - drug effects Hypothalamus - physiology Injections, Intraventricular Intracerebroventricular injection Male Microinjections Molecular Sequence Data Neurotensin - chemistry Oligopeptides - chemistry Peptides - chemistry Peptides - pharmacology Rats Rats, Wistar Satiation - drug effects Satiety Sodium Chloride - pharmacology Vertebrates: anatomy and physiology, studies on body, several organs or systems Xenin Xenopus Proteins |
| title | Xenin—a novel suppressor of food intake in rats |
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