Peroxynitrite formation within the central nervous system in active multiple sclerosis
Peroxynitrite, generated by the reaction of nitric oxide (NO) with superoxide at sites of inflammation, is a strong oxidant capable of damaging tissues and cells. Detection of nitrotyrosine (NT) at inflammatory sites serves as a biochemical marker for peroxynitrite-mediated damage. In this study, NT...
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| Veröffentlicht in: | Journal of neuroimmunology 1998-08, Vol.88 (1), p.45-56 |
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| container_title | Journal of neuroimmunology |
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| creator | Cross, Anne H Manning, Pamela T Keeling, Richard M Schmidt, Robert E Misko, Thomas P |
| description | Peroxynitrite, generated by the reaction of nitric oxide (NO) with superoxide at sites of inflammation, is a strong oxidant capable of damaging tissues and cells. Detection of nitrotyrosine (NT) at inflammatory sites serves as a biochemical marker for peroxynitrite-mediated damage. In this study, NT was detected immunohistochemically within autopsied CNS tissues from six of nine multiple sclerosis (MS) patients, and in most of the MS sections displaying inflammation. Nitrite and nitrate, the stable oxidation products of NO and peroxynitrite, respectively, were measured in cerebrospinal fluid samples obtained from MS patients and controls. Levels of nitrate were elevated significantly during clinical relapses of MS. These data suggest that peroxynitrite formation is a major consequence of NO produced in MS-affected CNS and implicate a role for this powerful oxidant in the pathogenesis of MS. |
| doi_str_mv | 10.1016/S0165-5728(98)00078-2 |
| format | Article |
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Detection of nitrotyrosine (NT) at inflammatory sites serves as a biochemical marker for peroxynitrite-mediated damage. In this study, NT was detected immunohistochemically within autopsied CNS tissues from six of nine multiple sclerosis (MS) patients, and in most of the MS sections displaying inflammation. Nitrite and nitrate, the stable oxidation products of NO and peroxynitrite, respectively, were measured in cerebrospinal fluid samples obtained from MS patients and controls. Levels of nitrate were elevated significantly during clinical relapses of MS. 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Detection of nitrotyrosine (NT) at inflammatory sites serves as a biochemical marker for peroxynitrite-mediated damage. In this study, NT was detected immunohistochemically within autopsied CNS tissues from six of nine multiple sclerosis (MS) patients, and in most of the MS sections displaying inflammation. Nitrite and nitrate, the stable oxidation products of NO and peroxynitrite, respectively, were measured in cerebrospinal fluid samples obtained from MS patients and controls. Levels of nitrate were elevated significantly during clinical relapses of MS. These data suggest that peroxynitrite formation is a major consequence of NO produced in MS-affected CNS and implicate a role for this powerful oxidant in the pathogenesis of MS.</description><subject>Central Nervous System - metabolism</subject><subject>Cerebrospinal fluid</subject><subject>Demyelination</subject><subject>Free radicals</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Inflammation - cerebrospinal fluid</subject><subject>Multiple Sclerosis - cerebrospinal fluid</subject><subject>Multiple Sclerosis - metabolism</subject><subject>Nervous System Diseases - cerebrospinal fluid</subject><subject>Nitrates - cerebrospinal fluid</subject><subject>Nitrates - metabolism</subject><subject>Nitric oxide</subject><subject>Nitrites - cerebrospinal fluid</subject><subject>Peroxynitrite</subject><subject>Recurrence</subject><subject>Tyrosine - analogs & derivatives</subject><subject>Tyrosine - metabolism</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkElLAzEYhoMotVZ_QiEn0cNoMsnMJCeR4gYFBZdryGS-oZFZapJW--9NF3rtJTm8z7c9CI0puaGE5rfv8cmSrEjFlRTXhJBCJOkRGlJRpIngKT1Gwz1yis68_yaEZozLARrIXAiWsiH6egPX_606G5wNgOvetTrYvsO_Nsxsh8MMsIEuON3gDtyyX3jsVz5Ai2OqTbBLwO2iCXbeAPamie289efopNaNh4vdP0Kfjw8fk-dk-vr0MrmfJoZzFhIgXAOraFbKtCYlZ4U0VAAXmmlDMw45YSKNV5Q1NTIzjFSSclrpMi-E1DUboctt37nrfxbgg2qtN9A0uoO4qhKEcCKz_CAYRfEishHMtqCJh3gHtZo722q3UpSotXi1Ea_WVpUUaiNepbFuvBuwKFuo9lU70zG_2-YQdSwtOOWNhc5AZR2YoKreHpjwD5cOk-A</recordid><startdate>19980801</startdate><enddate>19980801</enddate><creator>Cross, Anne H</creator><creator>Manning, Pamela T</creator><creator>Keeling, Richard M</creator><creator>Schmidt, Robert E</creator><creator>Misko, Thomas P</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980801</creationdate><title>Peroxynitrite formation within the central nervous system in active multiple sclerosis</title><author>Cross, Anne H ; Manning, Pamela T ; Keeling, Richard M ; Schmidt, Robert E ; Misko, Thomas P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-e04ae3d15b92f0b4379c18e48a3ac154e60382016bf1c95c30d9141dab6789af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Central Nervous System - metabolism</topic><topic>Cerebrospinal fluid</topic><topic>Demyelination</topic><topic>Free radicals</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Inflammation - cerebrospinal fluid</topic><topic>Multiple Sclerosis - cerebrospinal fluid</topic><topic>Multiple Sclerosis - metabolism</topic><topic>Nervous System Diseases - cerebrospinal fluid</topic><topic>Nitrates - cerebrospinal fluid</topic><topic>Nitrates - metabolism</topic><topic>Nitric oxide</topic><topic>Nitrites - cerebrospinal fluid</topic><topic>Peroxynitrite</topic><topic>Recurrence</topic><topic>Tyrosine - analogs & derivatives</topic><topic>Tyrosine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cross, Anne H</creatorcontrib><creatorcontrib>Manning, Pamela T</creatorcontrib><creatorcontrib>Keeling, Richard M</creatorcontrib><creatorcontrib>Schmidt, Robert E</creatorcontrib><creatorcontrib>Misko, Thomas P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cross, Anne H</au><au>Manning, Pamela T</au><au>Keeling, Richard M</au><au>Schmidt, Robert E</au><au>Misko, Thomas P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peroxynitrite formation within the central nervous system in active multiple sclerosis</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>1998-08-01</date><risdate>1998</risdate><volume>88</volume><issue>1</issue><spage>45</spage><epage>56</epage><pages>45-56</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Peroxynitrite, generated by the reaction of nitric oxide (NO) with superoxide at sites of inflammation, is a strong oxidant capable of damaging tissues and cells. 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| ispartof | Journal of neuroimmunology, 1998-08, Vol.88 (1), p.45-56 |
| issn | 0165-5728 1872-8421 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Central Nervous System - metabolism Cerebrospinal fluid Demyelination Free radicals Humans Immunohistochemistry Inflammation - cerebrospinal fluid Multiple Sclerosis - cerebrospinal fluid Multiple Sclerosis - metabolism Nervous System Diseases - cerebrospinal fluid Nitrates - cerebrospinal fluid Nitrates - metabolism Nitric oxide Nitrites - cerebrospinal fluid Peroxynitrite Recurrence Tyrosine - analogs & derivatives Tyrosine - metabolism |
| title | Peroxynitrite formation within the central nervous system in active multiple sclerosis |
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