Methoxy poly(ethylene glycol) and ϵ-caprolactone amphiphilic block copolymeric micelle containing indomethacin. : II. Micelle formation and drug release behaviours

Amphiphilic diblock copolymer composed of methoxy poly(ethylene glycol) (MePEG) and ε-caprolactone ( ε-CL) was prepared by polymerization of ε-CL initiated with MePEG. MePEG/ ε-CL block copolymeric micelles containing indomethacin (IMC) were prepared by a dialysis method and evaluated as a novel dru...

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Veröffentlicht in:	Journal of controlled release 1998-01, Vol.51 (1), p.13-22
Hauptverfasser:	Kim, So Yeon, Shin, IL Gyun, Lee, Young Moo, Cho, Chong Su, Sung, Yong Kiel
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemistry Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Chemistry, Pharmaceutical Controlled release system Delayed-Action Preparations General pharmacology Indomethacin Indomethacin - administration & dosage Indomethacin - chemistry Medical sciences Methoxypolyethylene/ ε-caprolactone block copolymer Micelle Micelles Molecular Weight Nanosphere Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyesters - chemistry Polyethylene Glycols - chemistry Polymers - chemical synthesis Polymers - chemistry Structure-Activity Relationship
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