Methoxy poly(ethylene glycol) and ϵ-caprolactone amphiphilic block copolymeric micelle containing indomethacin. : II. Micelle formation and drug release behaviours
Amphiphilic diblock copolymer composed of methoxy poly(ethylene glycol) (MePEG) and ε-caprolactone ( ε-CL) was prepared by polymerization of ε-CL initiated with MePEG. MePEG/ ε-CL block copolymeric micelles containing indomethacin (IMC) were prepared by a dialysis method and evaluated as a novel dru...
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| Veröffentlicht in: | Journal of controlled release 1998-01, Vol.51 (1), p.13-22 |
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| container_title | Journal of controlled release |
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| creator | Kim, So Yeon Shin, IL Gyun Lee, Young Moo Cho, Chong Su Sung, Yong Kiel |
| description | Amphiphilic diblock copolymer composed of methoxy poly(ethylene glycol) (MePEG) and
ε-caprolactone (
ε-CL) was prepared by polymerization of
ε-CL initiated with MePEG. MePEG/
ε-CL block copolymeric micelles containing indomethacin (IMC) were prepared by a dialysis method and evaluated as a novel drug carrier. The size of micelle formed was less than 200 nm, and the size distribution of the micelle showed a narrow and monodisperse unimodal pattern. Also, the micelles formed by a dialysis method exhibited spherical structures. The indomethacin content in nanospheres was about 42.2%, for those prepared using copolymer, having molecular weight of about 12 000 and polymer/IMC weight ratio of 1/1. A release rate of indomethacin from nanospheres was slow, and thus the release continued over 15 days. As the molecular weights of the copolymer and the amount of drug entrapped increased, the release rate decreased. These results indicated that the drug-loaded nanospheres could be useful as a novel drug carrier in injectable delivery systems for hydrophobic drugs. |
| doi_str_mv | 10.1016/S0168-3659(97)00124-7 |
| format | Article |
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ε-caprolactone (
ε-CL) was prepared by polymerization of
ε-CL initiated with MePEG. MePEG/
ε-CL block copolymeric micelles containing indomethacin (IMC) were prepared by a dialysis method and evaluated as a novel drug carrier. The size of micelle formed was less than 200 nm, and the size distribution of the micelle showed a narrow and monodisperse unimodal pattern. Also, the micelles formed by a dialysis method exhibited spherical structures. The indomethacin content in nanospheres was about 42.2%, for those prepared using copolymer, having molecular weight of about 12 000 and polymer/IMC weight ratio of 1/1. A release rate of indomethacin from nanospheres was slow, and thus the release continued over 15 days. As the molecular weights of the copolymer and the amount of drug entrapped increased, the release rate decreased. These results indicated that the drug-loaded nanospheres could be useful as a novel drug carrier in injectable delivery systems for hydrophobic drugs.</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/S0168-3659(97)00124-7</identifier><identifier>PMID: 9685900</identifier><identifier>CODEN: JCREEC</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Chemistry, Pharmaceutical ; Controlled release system ; Delayed-Action Preparations ; General pharmacology ; Indomethacin ; Indomethacin - administration & dosage ; Indomethacin - chemistry ; Medical sciences ; Methoxypolyethylene/ ε-caprolactone block copolymer ; Micelle ; Micelles ; Molecular Weight ; Nanosphere ; Particle Size ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Polyesters - chemistry ; Polyethylene Glycols - chemistry ; Polymers - chemical synthesis ; Polymers - chemistry ; Structure-Activity Relationship</subject><ispartof>Journal of controlled release, 1998-01, Vol.51 (1), p.13-22</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0168-3659(97)00124-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2132530$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9685900$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, So Yeon</creatorcontrib><creatorcontrib>Shin, IL Gyun</creatorcontrib><creatorcontrib>Lee, Young Moo</creatorcontrib><creatorcontrib>Cho, Chong Su</creatorcontrib><creatorcontrib>Sung, Yong Kiel</creatorcontrib><title>Methoxy poly(ethylene glycol) and ϵ-caprolactone amphiphilic block copolymeric micelle containing indomethacin. : II. Micelle formation and drug release behaviours</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>Amphiphilic diblock copolymer composed of methoxy poly(ethylene glycol) (MePEG) and
ε-caprolactone (
ε-CL) was prepared by polymerization of
ε-CL initiated with MePEG. MePEG/
ε-CL block copolymeric micelles containing indomethacin (IMC) were prepared by a dialysis method and evaluated as a novel drug carrier. The size of micelle formed was less than 200 nm, and the size distribution of the micelle showed a narrow and monodisperse unimodal pattern. Also, the micelles formed by a dialysis method exhibited spherical structures. The indomethacin content in nanospheres was about 42.2%, for those prepared using copolymer, having molecular weight of about 12 000 and polymer/IMC weight ratio of 1/1. A release rate of indomethacin from nanospheres was slow, and thus the release continued over 15 days. As the molecular weights of the copolymer and the amount of drug entrapped increased, the release rate decreased. These results indicated that the drug-loaded nanospheres could be useful as a novel drug carrier in injectable delivery systems for hydrophobic drugs.</description><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Chemistry, Pharmaceutical</subject><subject>Controlled release system</subject><subject>Delayed-Action Preparations</subject><subject>General pharmacology</subject><subject>Indomethacin</subject><subject>Indomethacin - administration & dosage</subject><subject>Indomethacin - chemistry</subject><subject>Medical sciences</subject><subject>Methoxypolyethylene/ ε-caprolactone block copolymer</subject><subject>Micelle</subject><subject>Micelles</subject><subject>Molecular Weight</subject><subject>Nanosphere</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Polyesters - chemistry</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polymers - chemical synthesis</subject><subject>Polymers - chemistry</subject><subject>Structure-Activity Relationship</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kctu1DAUhiMEKkPhESp5gVC7yHAc52Y2Faq4jNSKBbC2HPtkxuDYg51U5H14BZ6DV8KZRpUs2zr_53Pxn2UXFLYUaP32a9ranNUVv-TNFQAtyrx5km1o27C85Lx6mm0ekefZixh_AEDFyuYsO-N1W3GATfbnDseD_z2To7fzZbrPFh2SvZ2Vt1dEOk3-_c2VPAZvpRp90uRwPJi0rFGks179JMovrwcMKTIYhdZiirlRGmfcnhin_ZBSS2Xclrwju92W3K1Y78MgR-PdqZQO054EtCgjkg4P8t74KcSX2bNe2oiv1vM8-_7xw7ebz_ntl0-7m_e3ORacjjkyBdjVrC972vd9RaEroG9bypLeVZpjC1rrsi4b0AyhZryjvSwAWl1CAew8e_OQN037a8I4isHEpU_p0E9RtACMN6xM4MUKTt2AWhyDGWSYxfqtSX-96jIqafsgnTLxESsoKyq2YNcPGKah7g0GEZVBp1CbgGoU2htBQSx2i5PdYvFS8Eac7BYN-w_T2Z-x</recordid><startdate>19980123</startdate><enddate>19980123</enddate><creator>Kim, So Yeon</creator><creator>Shin, IL Gyun</creator><creator>Lee, Young Moo</creator><creator>Cho, Chong Su</creator><creator>Sung, Yong Kiel</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19980123</creationdate><title>Methoxy poly(ethylene glycol) and ϵ-caprolactone amphiphilic block copolymeric micelle containing indomethacin. : II. Micelle formation and drug release behaviours</title><author>Kim, So Yeon ; Shin, IL Gyun ; Lee, Young Moo ; Cho, Chong Su ; Sung, Yong Kiel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e291t-e3c0eb63f4f1fff510b20f8813e29b5d9e80ddd46470d3e0639b1fa2008d40203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemistry</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Chemistry, Pharmaceutical</topic><topic>Controlled release system</topic><topic>Delayed-Action Preparations</topic><topic>General pharmacology</topic><topic>Indomethacin</topic><topic>Indomethacin - administration & dosage</topic><topic>Indomethacin - chemistry</topic><topic>Medical sciences</topic><topic>Methoxypolyethylene/ ε-caprolactone block copolymer</topic><topic>Micelle</topic><topic>Micelles</topic><topic>Molecular Weight</topic><topic>Nanosphere</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Polyesters - chemistry</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polymers - chemical synthesis</topic><topic>Polymers - chemistry</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, So Yeon</creatorcontrib><creatorcontrib>Shin, IL Gyun</creatorcontrib><creatorcontrib>Lee, Young Moo</creatorcontrib><creatorcontrib>Cho, Chong Su</creatorcontrib><creatorcontrib>Sung, Yong Kiel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, So Yeon</au><au>Shin, IL Gyun</au><au>Lee, Young Moo</au><au>Cho, Chong Su</au><au>Sung, Yong Kiel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methoxy poly(ethylene glycol) and ϵ-caprolactone amphiphilic block copolymeric micelle containing indomethacin. : II. Micelle formation and drug release behaviours</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>1998-01-23</date><risdate>1998</risdate><volume>51</volume><issue>1</issue><spage>13</spage><epage>22</epage><pages>13-22</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><coden>JCREEC</coden><abstract>Amphiphilic diblock copolymer composed of methoxy poly(ethylene glycol) (MePEG) and
ε-caprolactone (
ε-CL) was prepared by polymerization of
ε-CL initiated with MePEG. MePEG/
ε-CL block copolymeric micelles containing indomethacin (IMC) were prepared by a dialysis method and evaluated as a novel drug carrier. The size of micelle formed was less than 200 nm, and the size distribution of the micelle showed a narrow and monodisperse unimodal pattern. Also, the micelles formed by a dialysis method exhibited spherical structures. The indomethacin content in nanospheres was about 42.2%, for those prepared using copolymer, having molecular weight of about 12 000 and polymer/IMC weight ratio of 1/1. A release rate of indomethacin from nanospheres was slow, and thus the release continued over 15 days. As the molecular weights of the copolymer and the amount of drug entrapped increased, the release rate decreased. These results indicated that the drug-loaded nanospheres could be useful as a novel drug carrier in injectable delivery systems for hydrophobic drugs.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9685900</pmid><doi>10.1016/S0168-3659(97)00124-7</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-3659 |
| ispartof | Journal of controlled release, 1998-01, Vol.51 (1), p.13-22 |
| issn | 0168-3659 1873-4995 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemistry Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Chemistry, Pharmaceutical Controlled release system Delayed-Action Preparations General pharmacology Indomethacin Indomethacin - administration & dosage Indomethacin - chemistry Medical sciences Methoxypolyethylene/ ε-caprolactone block copolymer Micelle Micelles Molecular Weight Nanosphere Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyesters - chemistry Polyethylene Glycols - chemistry Polymers - chemical synthesis Polymers - chemistry Structure-Activity Relationship |
| title | Methoxy poly(ethylene glycol) and ϵ-caprolactone amphiphilic block copolymeric micelle containing indomethacin. : II. Micelle formation and drug release behaviours |
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