4-Heterocyclyloxy-2H-1-benzopyran potassium channel activators

The reaction of 2,4-dihydroxypyridine (2) with 3,4-epoxy-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile (1) yielded the 4-[(1,2-dihydro-2-oxo-4-pyridyl)oxy] compound 3a, accompanied by small amounts of the isomeric 4-(1,2-dihydro-4-hydroxy-2-oxo-1-pyridyl) compound 4. This could also be pre...

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Veröffentlicht in:	Journal of medicinal chemistry 1990-10, Vol.33 (10), p.2759-2767
Hauptverfasser:	Bergmann, Rolf, Eiermann, Volker, Gericke, Rolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - chemical synthesis Antihypertensive Agents - chemistry Benzopyrans - chemical synthesis Benzopyrans - chemistry Chemical Phenomena Chemistry Chemistry, Physical Crystallography Dose-Response Relationship, Drug Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Magnetic Resonance Spectroscopy Molecular Structure Organic chemistry Potassium Channels - drug effects Preparations and properties Rats Rats, Inbred SHR Structure-Activity Relationship X-Ray Diffraction
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