Potential risk of oral insulin with adjuvant for the prevention of Type I diabetes : a protocol effective in NOD mice may exacerbate disease in BB rats

The impact of oral treatment with insulin on disease development was studied in diabetes prone BB rats. Because of the positive outcome of a prior study in non obese diabetic (NOD) mice, BB rats received insulin in combination with a bacterial adjuvant. Porcine insulin was given orally twice weekly...

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Veröffentlicht in:	Diabetologia 1998-07, Vol.41 (7), p.844-847
Hauptverfasser:	BELLMANN, K, KOLB, H, RASTEGAR, S, JEE, P, SCOTT, F. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - therapeutic use Aging AIDS/HIV Animals Antigens, Bacterial - administration & dosage Antigens, Bacterial - therapeutic use Biological and medical sciences Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - physiopathology Diabetes Mellitus, Type 1 - prevention & control Escherichia coli - immunology General and cellular metabolism. Vitamins Immunity, Mucosal Insulin - administration & dosage Insulin - therapeutic use Interferon-gamma - genetics Interleukin-10 - genetics Intestinal Mucosa - immunology Islets of Langerhans - pathology Medical sciences Mice Mice, Inbred NOD Pharmacology. Drug treatments Polymerase Chain Reaction Rats Rats, Inbred BB Risk Factors Th1 Cells - immunology Time Factors
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