Substituted 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-ones as potential antiinflammatory agents

A series of analogues based on the 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one ring system have been synthesized and shown to possess oral antiinflammatory activity in both the reverse passive Arthus reaction (RPAR) pleural cavity assay in rats and in the adjuvant-induced arthritic rat model (AAR). S...

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Veröffentlicht in:	Journal of medicinal chemistry 1990-10, Vol.33 (10), p.2697-2706
Hauptverfasser:	Ting, Pauline C, Kaminski, James J, Sherlock, Margaret H, Tom, Wing C, Lee, Joe F, Bryant, Robert W, Watnick, Arthur S, McPhail, Andrew T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Arthritis, Experimental - drug therapy Arthus Reaction Blood Platelets - enzymology Cyclooxygenase Inhibitors Drug Evaluation Humans In Vitro Techniques Lipoxygenase Inhibitors Neutrophils - enzymology Pyridones - chemical synthesis Pyridones - chemistry Pyridones - pharmacology Pyrroles - chemical synthesis Pyrroles - chemistry Pyrroles - pharmacology Rats Structure-Activity Relationship
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