Protein S-thiolation and redox regulation of membrane-bound glutathione transferase

Membrane-bound GST transferase (GSTm) occurs in hepatic microsomal and plasma membranes as well as in the outer mitochondrial membrane, and it is known to be activated by N-ethylmaleimide. We recently analysed the activation by GSSG in some detail. The ≈5-fold stimulation is reversed upon reduction...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemico-biological interactions 1998-04, Vol.111, p.177-185
Hauptverfasser:	Sies, Helmut, Dafré, Alcir L, Ji, Yanbin, Akerboom, Theodorus P.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Membrane - enzymology Enzyme Activation - drug effects Free radicals Glutathione Disulfide - pharmacology Glutathione transferase Glutathione Transferase - metabolism Hydroperoxides Intracellular Membranes - enzymology Lipid Peroxidation Liver - enzymology Microsomes Microsomes, Liver - enzymology Mitochondria, Liver - enzymology Oxidation-Reduction Oxidative Stress Protein mixed disulfides Rats S-thiolation Sulfhydryl Compounds - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!