Purification and identification of dTDP-oleandrose, the precursor of the oleandrose units of the avermectins

The nucleotide sugar precursor of the oleandrose units of the avermectins has been purified from a mutant of Streptomyces avermitilis, which does not synthesize any avermectins but which converts avermectin aglycones to their respective disaccharides. This precursor has been identified as dTDP-olean...

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Veröffentlicht in:	The Journal of biological chemistry 1990-10, Vol.265 (28), p.16965-16970
Hauptverfasser:	Schulman, M D, Acton, S L, Valentino, D L, Arison, B H
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry antibioticos antibiotics antibiotique Antiprotozoal Agents Biological and medical sciences biosintesis biosynthese biosynthesis Carbohydrates Cell-Free System Chromatography, High Pressure Liquid Fundamental and applied biological sciences. Psychology glicosiltransferasas Glycosylation glycosyltransferase glycosyltransferases Hexoses - isolation & purification Indicators and Reagents Ivermectin - analogs & derivatives nucleotide nucleotides nucleotidos Oses Other biological molecules streptomyces Streptomyces - metabolism Streptomyces avermitilis Thymine Nucleotides - isolation & purification
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