Involvement of the multilineage CD38 molecule in a unique pathway of cell activation and proliferation
We report clear evidence that the interaction of the CD38 molecule with the specific mAb A10 on normal human cells and lines modulates the expression of surface activation markers relevant to T, NK, and plasma cell biology and functions. Moreover A10 mAb binding is followed by proliferation effects...
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| Veröffentlicht in: | The Journal of immunology (1950) 1990-10, Vol.145 (8), p.2390-2396 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 145 |
| creator | Funaro, A Spagnoli, GC Ausiello, CM Alessio, M Roggero, S Delia, D Zaccolo, M Malavasi, F |
| description | We report clear evidence that the interaction of the CD38 molecule with the specific mAb A10 on normal human cells and lines modulates the expression of surface activation markers relevant to T, NK, and plasma cell biology and functions. Moreover A10 mAb binding is followed by proliferation effects on all the target cells analyzed, and the phenomenon is accessory cell and IL-2 dependent. The effects of A10 mAb synergizing both CD2 and CD3 activation pathways indicate that CD38 signal transduction mechanism(s) are apparently different from the aforementioned. Nevertheless the decreased A10-driven proliferation after CD3-Ti modulation suggests a possible functional interdependence between these activation pathways. Taken together, the results indicate that the CD38 molecule might play a physiologic role in T, NK, and plasma cell regulation. |
| doi_str_mv | 10.4049/jimmunol.145.8.2390 |
| format | Article |
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Moreover A10 mAb binding is followed by proliferation effects on all the target cells analyzed, and the phenomenon is accessory cell and IL-2 dependent. The effects of A10 mAb synergizing both CD2 and CD3 activation pathways indicate that CD38 signal transduction mechanism(s) are apparently different from the aforementioned. Nevertheless the decreased A10-driven proliferation after CD3-Ti modulation suggests a possible functional interdependence between these activation pathways. Taken together, the results indicate that the CD38 molecule might play a physiologic role in T, NK, and plasma cell regulation.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.145.8.2390</identifier><identifier>PMID: 1976692</identifier><identifier>CODEN: JOIMA3</identifier><language>eng</language><publisher>Bethesda, MD: Am Assoc Immnol</publisher><subject>ADP-ribosyl Cyclase ; ADP-ribosyl Cyclase 1 ; Antibodies, Monoclonal - immunology ; Antigens, CD - physiology ; Antigens, Differentiation - physiology ; Antigens, Differentiation, T-Lymphocyte - physiology ; Biological and medical sciences ; CD2 Antigens ; CD3 Complex ; Cell Division ; Cell Line ; Flow Cytometry ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; HLA-D Antigens - analysis ; Humans ; Immunobiology ; In Vitro Techniques ; Killer Cells, Natural - immunology ; Lymphocyte Activation ; Membrane Glycoproteins ; Modulation of the immune response (stimulation, suppression) ; Plasma Cells - immunology ; Receptors, Antigen, T-Cell - physiology ; Receptors, Immunologic - physiology ; Receptors, Interleukin-2 - analysis ; T-Lymphocytes - immunology ; Tumor Cells, Cultured</subject><ispartof>The Journal of immunology (1950), 1990-10, Vol.145 (8), p.2390-2396</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-ad688067a6cd8964713ad492a67dccd620ce108b6ef9d98a471be9f1593384d63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4516965$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1976692$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Funaro, A</creatorcontrib><creatorcontrib>Spagnoli, GC</creatorcontrib><creatorcontrib>Ausiello, CM</creatorcontrib><creatorcontrib>Alessio, M</creatorcontrib><creatorcontrib>Roggero, S</creatorcontrib><creatorcontrib>Delia, D</creatorcontrib><creatorcontrib>Zaccolo, M</creatorcontrib><creatorcontrib>Malavasi, F</creatorcontrib><title>Involvement of the multilineage CD38 molecule in a unique pathway of cell activation and proliferation</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>We report clear evidence that the interaction of the CD38 molecule with the specific mAb A10 on normal human cells and lines modulates the expression of surface activation markers relevant to T, NK, and plasma cell biology and functions. Moreover A10 mAb binding is followed by proliferation effects on all the target cells analyzed, and the phenomenon is accessory cell and IL-2 dependent. The effects of A10 mAb synergizing both CD2 and CD3 activation pathways indicate that CD38 signal transduction mechanism(s) are apparently different from the aforementioned. Nevertheless the decreased A10-driven proliferation after CD3-Ti modulation suggests a possible functional interdependence between these activation pathways. Taken together, the results indicate that the CD38 molecule might play a physiologic role in T, NK, and plasma cell regulation.</description><subject>ADP-ribosyl Cyclase</subject><subject>ADP-ribosyl Cyclase 1</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antigens, CD - physiology</subject><subject>Antigens, Differentiation - physiology</subject><subject>Antigens, Differentiation, T-Lymphocyte - physiology</subject><subject>Biological and medical sciences</subject><subject>CD2 Antigens</subject><subject>CD3 Complex</subject><subject>Cell Division</subject><subject>Cell Line</subject><subject>Flow Cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>HLA-D Antigens - analysis</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>In Vitro Techniques</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lymphocyte Activation</subject><subject>Membrane Glycoproteins</subject><subject>Modulation of the immune response (stimulation, suppression)</subject><subject>Plasma Cells - immunology</subject><subject>Receptors, Antigen, T-Cell - physiology</subject><subject>Receptors, Immunologic - physiology</subject><subject>Receptors, Interleukin-2 - analysis</subject><subject>T-Lymphocytes - immunology</subject><subject>Tumor Cells, Cultured</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEQhi0EKqHwCxCSDwhOG8Zrrz-OKHxVqsSlnC3H9jaubG9Y72bVf4_TBOitp5Fmnved0bwIvSWwZsDUp7uQ0pyHuCasW8t1SxU8QyvSddBwDvw5WgG0bUMEFy_Rq1LuAIBDyy7QBVGCc9WuUH-VD0M8-OTzhIceTzuP0xynEEP25tbjzRcqcRqit3P0OGRs8JzD79njvZl2i7k_qqyPERs7hYOZwlCZ7PB-HGLo_fjQeY1e9CYW_-ZcL9Gvb19vNj-a65_frzafrxvbtWJqjONSAheGWycVZ4JQ45hqDRfOWsdbsJ6A3HLfK6ekqcDWq550ilLJHKeX6MPJt26vN5ZJp1CO15nsh7loCUCZoPRJkHCA-iNRQXoC7TiUMvpe78eQzHivCehjDPpvDLrGoKU-xlBV78728zZ5919z-nudvz_PTbEm9qPJNpR_GOsIV7yr2McTtgu3uyWMXpdkYqymRC_L8mjhH4eXoJY</recordid><startdate>19901015</startdate><enddate>19901015</enddate><creator>Funaro, A</creator><creator>Spagnoli, GC</creator><creator>Ausiello, CM</creator><creator>Alessio, M</creator><creator>Roggero, S</creator><creator>Delia, D</creator><creator>Zaccolo, M</creator><creator>Malavasi, F</creator><general>Am Assoc Immnol</general><general>American Association of Immunologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19901015</creationdate><title>Involvement of the multilineage CD38 molecule in a unique pathway of cell activation and proliferation</title><author>Funaro, A ; Spagnoli, GC ; Ausiello, CM ; Alessio, M ; Roggero, S ; Delia, D ; Zaccolo, M ; Malavasi, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-ad688067a6cd8964713ad492a67dccd620ce108b6ef9d98a471be9f1593384d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>ADP-ribosyl Cyclase</topic><topic>ADP-ribosyl Cyclase 1</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antigens, CD - physiology</topic><topic>Antigens, Differentiation - physiology</topic><topic>Antigens, Differentiation, T-Lymphocyte - physiology</topic><topic>Biological and medical sciences</topic><topic>CD2 Antigens</topic><topic>CD3 Complex</topic><topic>Cell Division</topic><topic>Cell Line</topic><topic>Flow Cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>HLA-D Antigens - analysis</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>In Vitro Techniques</topic><topic>Killer Cells, Natural - immunology</topic><topic>Lymphocyte Activation</topic><topic>Membrane Glycoproteins</topic><topic>Modulation of the immune response (stimulation, suppression)</topic><topic>Plasma Cells - immunology</topic><topic>Receptors, Antigen, T-Cell - physiology</topic><topic>Receptors, Immunologic - physiology</topic><topic>Receptors, Interleukin-2 - analysis</topic><topic>T-Lymphocytes - immunology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Funaro, A</creatorcontrib><creatorcontrib>Spagnoli, GC</creatorcontrib><creatorcontrib>Ausiello, CM</creatorcontrib><creatorcontrib>Alessio, M</creatorcontrib><creatorcontrib>Roggero, S</creatorcontrib><creatorcontrib>Delia, D</creatorcontrib><creatorcontrib>Zaccolo, M</creatorcontrib><creatorcontrib>Malavasi, F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Funaro, A</au><au>Spagnoli, GC</au><au>Ausiello, CM</au><au>Alessio, M</au><au>Roggero, S</au><au>Delia, D</au><au>Zaccolo, M</au><au>Malavasi, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of the multilineage CD38 molecule in a unique pathway of cell activation and proliferation</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1990-10-15</date><risdate>1990</risdate><volume>145</volume><issue>8</issue><spage>2390</spage><epage>2396</epage><pages>2390-2396</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><coden>JOIMA3</coden><abstract>We report clear evidence that the interaction of the CD38 molecule with the specific mAb A10 on normal human cells and lines modulates the expression of surface activation markers relevant to T, NK, and plasma cell biology and functions. Moreover A10 mAb binding is followed by proliferation effects on all the target cells analyzed, and the phenomenon is accessory cell and IL-2 dependent. The effects of A10 mAb synergizing both CD2 and CD3 activation pathways indicate that CD38 signal transduction mechanism(s) are apparently different from the aforementioned. Nevertheless the decreased A10-driven proliferation after CD3-Ti modulation suggests a possible functional interdependence between these activation pathways. Taken together, the results indicate that the CD38 molecule might play a physiologic role in T, NK, and plasma cell regulation.</abstract><cop>Bethesda, MD</cop><pub>Am Assoc Immnol</pub><pmid>1976692</pmid><doi>10.4049/jimmunol.145.8.2390</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | ADP-ribosyl Cyclase ADP-ribosyl Cyclase 1 Antibodies, Monoclonal - immunology Antigens, CD - physiology Antigens, Differentiation - physiology Antigens, Differentiation, T-Lymphocyte - physiology Biological and medical sciences CD2 Antigens CD3 Complex Cell Division Cell Line Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology HLA-D Antigens - analysis Humans Immunobiology In Vitro Techniques Killer Cells, Natural - immunology Lymphocyte Activation Membrane Glycoproteins Modulation of the immune response (stimulation, suppression) Plasma Cells - immunology Receptors, Antigen, T-Cell - physiology Receptors, Immunologic - physiology Receptors, Interleukin-2 - analysis T-Lymphocytes - immunology Tumor Cells, Cultured |
| title | Involvement of the multilineage CD38 molecule in a unique pathway of cell activation and proliferation |
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