Effects of metyrapone and dexamethasone upon pro-gamma-MSH plasma levels in depressed patients and healthy controls
There is current controversy over the mechanisms underlying hypothalamic-pituitary-adrenal (HPA) axis hyperactivity in depression. Pro-γ-melanocyte-stimulating hormone (MSH), a portion of the N-terminal region of pro-opiomelanocortin, has been shown to act synergistically with adrenocorticotropic ho...
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| Veröffentlicht in: | Journal of affective disorders 1990-07, Vol.19 (3), p.183-189 |
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| container_title | Journal of affective disorders |
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| creator | Morphy, M.A. Fava, G.A. Pedersen, R.C. Zielezny, M. Sonino, N. Brownie, A.C. |
| description | There is current controversy over the mechanisms underlying hypothalamic-pituitary-adrenal (HPA) axis hyperactivity in depression. Pro-γ-melanocyte-stimulating hormone (MSH), a portion of the N-terminal region of pro-opiomelanocortin, has been shown to act synergistically with adrenocorticotropic hormone (ACTH) in stimulating corticosteroid secretion both in vitro and in vivo. Pro-γ-MSH and ACTH plasma levels were measured in 30 drug-free male patients with a DSM-IIIR major depressive disorder and 21 healthy controls. The baseline levels were similar in the two groups. After single-dose metyrapone stimulation, both hormones increased, but pro-γ-MSH was significantly higher in control subjects than in depressives. After overnight 1-mg dexamethasone, ACTH was significantly less suppressed in depressives than controls. These results suggest that HPA axis dysregulation in depression may involve peptides other than ACTH and be more complex than previously reported. |
| doi_str_mv | 10.1016/0165-0327(90)90090-U |
| format | Article |
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Pro-γ-melanocyte-stimulating hormone (MSH), a portion of the N-terminal region of pro-opiomelanocortin, has been shown to act synergistically with adrenocorticotropic hormone (ACTH) in stimulating corticosteroid secretion both in vitro and in vivo. Pro-γ-MSH and ACTH plasma levels were measured in 30 drug-free male patients with a DSM-IIIR major depressive disorder and 21 healthy controls. The baseline levels were similar in the two groups. After single-dose metyrapone stimulation, both hormones increased, but pro-γ-MSH was significantly higher in control subjects than in depressives. After overnight 1-mg dexamethasone, ACTH was significantly less suppressed in depressives than controls. These results suggest that HPA axis dysregulation in depression may involve peptides other than ACTH and be more complex than previously reported.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/0165-0327(90)90090-U</identifier><identifier>PMID: 2170484</identifier><identifier>CODEN: JADID7</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adrenal gland hormones ; Adrenocorticotropic Hormone - blood ; Adult ; Biological and medical sciences ; Depression ; Depressive Disorder - blood ; Depressive Disorder - diagnosis ; Dexamethasone ; Humans ; Hydrocortisone - blood ; Hypothalamo-Hypophyseal System - physiopathology ; Male ; Medical sciences ; Metyrapone ; Middle Aged ; Miscellaneous ; Peptide Fragments - blood ; Pituitary-Adrenal System - physiopathology ; Pro-opiomelanocortin ; Pro-Opiomelanocortin - blood ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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Pro-γ-melanocyte-stimulating hormone (MSH), a portion of the N-terminal region of pro-opiomelanocortin, has been shown to act synergistically with adrenocorticotropic hormone (ACTH) in stimulating corticosteroid secretion both in vitro and in vivo. Pro-γ-MSH and ACTH plasma levels were measured in 30 drug-free male patients with a DSM-IIIR major depressive disorder and 21 healthy controls. The baseline levels were similar in the two groups. After single-dose metyrapone stimulation, both hormones increased, but pro-γ-MSH was significantly higher in control subjects than in depressives. After overnight 1-mg dexamethasone, ACTH was significantly less suppressed in depressives than controls. These results suggest that HPA axis dysregulation in depression may involve peptides other than ACTH and be more complex than previously reported.</description><subject>Adrenal gland hormones</subject><subject>Adrenocorticotropic Hormone - blood</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Depression</subject><subject>Depressive Disorder - blood</subject><subject>Depressive Disorder - diagnosis</subject><subject>Dexamethasone</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Hypothalamo-Hypophyseal System - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metyrapone</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Peptide Fragments - blood</subject><subject>Pituitary-Adrenal System - physiopathology</subject><subject>Pro-opiomelanocortin</subject><subject>Pro-Opiomelanocortin - blood</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Techniques and methods</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2LFDEQxYMo67j6HyjkouihtfLR6c5FkGV1hRUPOudQk652WvrLVM_i_PemnWG9eQiBV-89il8J8VzBWwXKvcuvLMDo6rWHNx7AQ7F9IDaqrEyhS1U9FJt7y2PxhPknADhfwYW40KoCW9uN4Ou2pbiwnFo50HJMOE8jSRwb2dBvzNIeeVUOWZdzmoofOAxYfPl2I-ceeUDZ0x31LLsxJ-ZEzNTIGZeOxly7Fu0J-2V_lHEalzT1_FQ8arFnenb-L8X24_X3q5vi9uunz1cfboto6moprNN6t3NEqEpnja2crUsqlatjrXTTtsYgKocWyLrSemia2qqd14Ys-RjNpXh16s1r_zoQL2HoOFLf40jTgUMNYGwJOhvtyRjTxJyoDXPqBkzHoCCsrMMKMqwgg4fwl3XY5tiLc_9hN1BzHzrDzfOX5zlyxL5NOMaO_3V7o73Wq-_9yZcx0l1HKXDM9CI1Xcq3Cc3U_X-RP5a9m7g</recordid><startdate>19900701</startdate><enddate>19900701</enddate><creator>Morphy, M.A.</creator><creator>Fava, G.A.</creator><creator>Pedersen, R.C.</creator><creator>Zielezny, M.</creator><creator>Sonino, N.</creator><creator>Brownie, A.C.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900701</creationdate><title>Effects of metyrapone and dexamethasone upon pro-gamma-MSH plasma levels in depressed patients and healthy controls</title><author>Morphy, M.A. ; Fava, G.A. ; Pedersen, R.C. ; Zielezny, M. ; Sonino, N. ; Brownie, A.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-4622bb6eea15643476485e5168c812dff33aa16a40e465490dd841b923e4e9cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adrenal gland hormones</topic><topic>Adrenocorticotropic Hormone - blood</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Depression</topic><topic>Depressive Disorder - blood</topic><topic>Depressive Disorder - diagnosis</topic><topic>Dexamethasone</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Hypothalamo-Hypophyseal System - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metyrapone</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Peptide Fragments - blood</topic><topic>Pituitary-Adrenal System - physiopathology</topic><topic>Pro-opiomelanocortin</topic><topic>Pro-Opiomelanocortin - blood</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Techniques and methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morphy, M.A.</creatorcontrib><creatorcontrib>Fava, G.A.</creatorcontrib><creatorcontrib>Pedersen, R.C.</creatorcontrib><creatorcontrib>Zielezny, M.</creatorcontrib><creatorcontrib>Sonino, N.</creatorcontrib><creatorcontrib>Brownie, A.C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morphy, M.A.</au><au>Fava, G.A.</au><au>Pedersen, R.C.</au><au>Zielezny, M.</au><au>Sonino, N.</au><au>Brownie, A.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of metyrapone and dexamethasone upon pro-gamma-MSH plasma levels in depressed patients and healthy controls</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>1990-07-01</date><risdate>1990</risdate><volume>19</volume><issue>3</issue><spage>183</spage><epage>189</epage><pages>183-189</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><coden>JADID7</coden><abstract>There is current controversy over the mechanisms underlying hypothalamic-pituitary-adrenal (HPA) axis hyperactivity in depression. Pro-γ-melanocyte-stimulating hormone (MSH), a portion of the N-terminal region of pro-opiomelanocortin, has been shown to act synergistically with adrenocorticotropic hormone (ACTH) in stimulating corticosteroid secretion both in vitro and in vivo. Pro-γ-MSH and ACTH plasma levels were measured in 30 drug-free male patients with a DSM-IIIR major depressive disorder and 21 healthy controls. The baseline levels were similar in the two groups. After single-dose metyrapone stimulation, both hormones increased, but pro-γ-MSH was significantly higher in control subjects than in depressives. After overnight 1-mg dexamethasone, ACTH was significantly less suppressed in depressives than controls. These results suggest that HPA axis dysregulation in depression may involve peptides other than ACTH and be more complex than previously reported.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2170484</pmid><doi>10.1016/0165-0327(90)90090-U</doi><tpages>7</tpages></addata></record> |
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| subjects | Adrenal gland hormones Adrenocorticotropic Hormone - blood Adult Biological and medical sciences Depression Depressive Disorder - blood Depressive Disorder - diagnosis Dexamethasone Humans Hydrocortisone - blood Hypothalamo-Hypophyseal System - physiopathology Male Medical sciences Metyrapone Middle Aged Miscellaneous Peptide Fragments - blood Pituitary-Adrenal System - physiopathology Pro-opiomelanocortin Pro-Opiomelanocortin - blood Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Techniques and methods |
| title | Effects of metyrapone and dexamethasone upon pro-gamma-MSH plasma levels in depressed patients and healthy controls |
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