Delivery of epitopes by the Salmonella type III secretion system for vaccine development
Avirulent strains of Salmonella typhimurium are being considered as antigen delivery vectors. During its intracellular stage in the host, S. typhimurium resides within a membrane-bound compartment and is not an efficient inducer of class I-restricted immune responses. Viral epitopes were successfull...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1998-07, Vol.281 (5376), p.565-568 |
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| creator | Russmann, H. (State University of New York at Stony Brook, Stony Brook, NY.) Shams, H Poblete, F Fu, Y Galan, J.E Donis, R.O |
| description | Avirulent strains of Salmonella typhimurium are being considered as antigen delivery vectors. During its intracellular stage in the host, S. typhimurium resides within a membrane-bound compartment and is not an efficient inducer of class I-restricted immune responses. Viral epitopes were successfully delivered to the host-cell cytosol by using the type III protein secretion system of S. typhimurium. This resulted in class restricted immune responses that protected vaccinated animals against lethal infection. This approach may allow the efficient use of S. typhimurium as an antigen delivery system to control infections by pathogens that require this type of immune response for protection |
| doi_str_mv | 10.1126/science.281.5376.565 |
| format | Article |
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(State University of New York at Stony Brook, Stony Brook, NY.) ; Shams, H ; Poblete, F ; Fu, Y ; Galan, J.E ; Donis, R.O</creator><creatorcontrib>Russmann, H. (State University of New York at Stony Brook, Stony Brook, NY.) ; Shams, H ; Poblete, F ; Fu, Y ; Galan, J.E ; Donis, R.O</creatorcontrib><description>Avirulent strains of Salmonella typhimurium are being considered as antigen delivery vectors. During its intracellular stage in the host, S. typhimurium resides within a membrane-bound compartment and is not an efficient inducer of class I-restricted immune responses. Viral epitopes were successfully delivered to the host-cell cytosol by using the type III protein secretion system of S. typhimurium. This resulted in class restricted immune responses that protected vaccinated animals against lethal infection. This approach may allow the efficient use of S. typhimurium as an antigen delivery system to control infections by pathogens that require this type of immune response for protection</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.281.5376.565</identifier><identifier>PMID: 9677200</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Animals ; ANTIGEN DELIVERY VECTORS ; Antigen Presentation ; ANTIGENE ; ANTIGENOS ; ANTIGENS ; Antigens, Viral - immunology ; Antigens, Viral - metabolism ; Bacteria ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Biological and medical sciences ; Cytosol ; Cytosol - immunology ; Delivery Systems ; Endoplasmic Reticulum - immunology ; Endoplasmic Reticulum - metabolism ; Epithelial cells ; Epitopes ; Epitopes - immunology ; Feedback (Response) ; Fundamental and applied biological sciences. Psychology ; Health aspects ; Histocompatibility Antigens Class I - immunology ; Hybridomas ; IMMUNE RESPONSE ; Immune system ; Immunology ; Infections ; Lymphocytic Choriomeningitis - prevention & control ; Lymphocytic choriomeningitis virus - immunology ; Mice ; Mice, Inbred C57BL ; Microbiology ; Nucleoproteins - immunology ; Nucleoproteins - metabolism ; Orthomyxoviridae ; Peptide Fragments - immunology ; Peptide Fragments - metabolism ; Plasmids ; Protein Tyrosine Phosphatases - genetics ; Protein Tyrosine Phosphatases - metabolism ; Recombinant Fusion Proteins - immunology ; Recombinant Fusion Proteins - metabolism ; REPONSE IMMUNITAIRE ; RESPUESTA INMUNOLOGICA ; Salmonella ; SALMONELLA TYPHIMURIUM ; Salmonella typhimurium - metabolism ; Salmonella typhimurium - pathogenicity ; Secretion ; Spleen cells ; STRAINS ; T lymphocytes ; T-Lymphocytes - immunology ; T-Lymphocytes, Cytotoxic - immunology ; Tumor Cells, Cultured ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Vaccines, Synthetic - administration & dosage ; Vaccines, Synthetic - immunology ; VECTEUR DE MALADIE ; VECTORES ; VECTORS ; Viral Core Proteins - immunology ; Viral Core Proteins - metabolism ; Viral vaccines ; Viral Vaccines - immunology ; Virology ; Virus-vector relationships</subject><ispartof>Science (American Association for the Advancement of Science), 1998-07, Vol.281 (5376), p.565-568</ispartof><rights>Copyright 1998 American Association for the Advancement of Science</rights><rights>1998 INIST-CNRS</rights><rights>COPYRIGHT 1998 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1998 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jul 24, 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-cecca4d85d9c812e9d38b9cd2e8bbb7659de981062849d9a0a76b6036a05428f3</citedby><cites>FETCH-LOGICAL-c758t-cecca4d85d9c812e9d38b9cd2e8bbb7659de981062849d9a0a76b6036a05428f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2895084$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2895084$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2354558$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9677200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Russmann, H. (State University of New York at Stony Brook, Stony Brook, NY.)</creatorcontrib><creatorcontrib>Shams, H</creatorcontrib><creatorcontrib>Poblete, F</creatorcontrib><creatorcontrib>Fu, Y</creatorcontrib><creatorcontrib>Galan, J.E</creatorcontrib><creatorcontrib>Donis, R.O</creatorcontrib><title>Delivery of epitopes by the Salmonella type III secretion system for vaccine development</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Avirulent strains of Salmonella typhimurium are being considered as antigen delivery vectors. During its intracellular stage in the host, S. typhimurium resides within a membrane-bound compartment and is not an efficient inducer of class I-restricted immune responses. Viral epitopes were successfully delivered to the host-cell cytosol by using the type III protein secretion system of S. typhimurium. This resulted in class restricted immune responses that protected vaccinated animals against lethal infection. This approach may allow the efficient use of S. typhimurium as an antigen delivery system to control infections by pathogens that require this type of immune response for protection</description><subject>Animals</subject><subject>ANTIGEN DELIVERY VECTORS</subject><subject>Antigen Presentation</subject><subject>ANTIGENE</subject><subject>ANTIGENOS</subject><subject>ANTIGENS</subject><subject>Antigens, Viral - immunology</subject><subject>Antigens, Viral - metabolism</subject><subject>Bacteria</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cytosol</subject><subject>Cytosol - immunology</subject><subject>Delivery Systems</subject><subject>Endoplasmic Reticulum - immunology</subject><subject>Endoplasmic Reticulum - metabolism</subject><subject>Epithelial cells</subject><subject>Epitopes</subject><subject>Epitopes - immunology</subject><subject>Feedback (Response)</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health aspects</subject><subject>Histocompatibility Antigens Class I - immunology</subject><subject>Hybridomas</subject><subject>IMMUNE RESPONSE</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Infections</subject><subject>Lymphocytic Choriomeningitis - prevention & control</subject><subject>Lymphocytic choriomeningitis virus - immunology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microbiology</subject><subject>Nucleoproteins - immunology</subject><subject>Nucleoproteins - metabolism</subject><subject>Orthomyxoviridae</subject><subject>Peptide Fragments - immunology</subject><subject>Peptide Fragments - metabolism</subject><subject>Plasmids</subject><subject>Protein Tyrosine Phosphatases - genetics</subject><subject>Protein Tyrosine Phosphatases - metabolism</subject><subject>Recombinant Fusion Proteins - immunology</subject><subject>Recombinant Fusion Proteins - metabolism</subject><subject>REPONSE IMMUNITAIRE</subject><subject>RESPUESTA INMUNOLOGICA</subject><subject>Salmonella</subject><subject>SALMONELLA TYPHIMURIUM</subject><subject>Salmonella typhimurium - metabolism</subject><subject>Salmonella typhimurium - pathogenicity</subject><subject>Secretion</subject><subject>Spleen cells</subject><subject>STRAINS</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Tumor Cells, Cultured</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Vaccines, Synthetic - administration & dosage</subject><subject>Vaccines, Synthetic - immunology</subject><subject>VECTEUR DE MALADIE</subject><subject>VECTORES</subject><subject>VECTORS</subject><subject>Viral Core Proteins - immunology</subject><subject>Viral Core Proteins - metabolism</subject><subject>Viral vaccines</subject><subject>Viral Vaccines - immunology</subject><subject>Virology</subject><subject>Virus-vector relationships</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0u-L0zAYB_AiyjlP_4MTgoj64jqTtGmTl-fUORjuxTzxXUjTpzOjbXpJNtx_b8bGHZMhR14E8nzy-5skVwSPCaHFR68N9BrGlJMxy8pizAr2JBkRLFgqKM6eJiOMsyLluGTPkxferzGONZFdJBeiKEuK8Sj59RlaswW3Q7ZBMJhgB_Co2qHwG9BStZ3toW0VCrsB0Gw2Qx60g2Bsj_zOB-hQYx3aKq1ND6iGLbR26KAPL5NnjWo9vDr2l8nt1y8_Jt_S-WI6m9zMU10yHlINWqu85qwWmhMKos54JXRNgVdVVRZM1CA4wQXluaiFwqosqiJeS2GWU95kl8m7w7qDs3cb8EF2xuv9mXuwGy95fIM8FzzC9_-FZZ6REnOcRfnmH7m2G9fHW0hKMlaQnBcRXR_QSrUgTd_Y4JReQQ9OtfHRGhOHbyiOO5Nyz9MzPLYaOqPP-Q8nPpIAf8JKbbyXs-X3R9PFz0fTT9PHUj6dn9Drc1TbtoUVyPjdk8UJzw9cO-u9g0YOznTK7STBcp9seUy2jMmW-2TLmOw47fXxVzZVB_X9pGOUY_3tsa68Vm3jVK-Nv2c0Yzlj-xhcHdjaB-seylwwzPOHXRplpVq5uMLtkgghMCbxJNlfVU0Pjw</recordid><startdate>19980724</startdate><enddate>19980724</enddate><creator>Russmann, H. 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(State University of New York at Stony Brook, Stony Brook, NY.) ; Shams, H ; Poblete, F ; Fu, Y ; Galan, J.E ; Donis, R.O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-cecca4d85d9c812e9d38b9cd2e8bbb7659de981062849d9a0a76b6036a05428f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>ANTIGEN DELIVERY VECTORS</topic><topic>Antigen Presentation</topic><topic>ANTIGENE</topic><topic>ANTIGENOS</topic><topic>ANTIGENS</topic><topic>Antigens, Viral - immunology</topic><topic>Antigens, Viral - metabolism</topic><topic>Bacteria</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacterial Proteins - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cytosol</topic><topic>Cytosol - immunology</topic><topic>Delivery Systems</topic><topic>Endoplasmic Reticulum - immunology</topic><topic>Endoplasmic Reticulum - metabolism</topic><topic>Epithelial cells</topic><topic>Epitopes</topic><topic>Epitopes - immunology</topic><topic>Feedback (Response)</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health aspects</topic><topic>Histocompatibility Antigens Class I - immunology</topic><topic>Hybridomas</topic><topic>IMMUNE RESPONSE</topic><topic>Immune system</topic><topic>Immunology</topic><topic>Infections</topic><topic>Lymphocytic Choriomeningitis - prevention & control</topic><topic>Lymphocytic choriomeningitis virus - immunology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microbiology</topic><topic>Nucleoproteins - immunology</topic><topic>Nucleoproteins - metabolism</topic><topic>Orthomyxoviridae</topic><topic>Peptide Fragments - immunology</topic><topic>Peptide Fragments - metabolism</topic><topic>Plasmids</topic><topic>Protein Tyrosine Phosphatases - genetics</topic><topic>Protein Tyrosine Phosphatases - metabolism</topic><topic>Recombinant Fusion Proteins - immunology</topic><topic>Recombinant Fusion Proteins - metabolism</topic><topic>REPONSE IMMUNITAIRE</topic><topic>RESPUESTA INMUNOLOGICA</topic><topic>Salmonella</topic><topic>SALMONELLA TYPHIMURIUM</topic><topic>Salmonella typhimurium - metabolism</topic><topic>Salmonella typhimurium - pathogenicity</topic><topic>Secretion</topic><topic>Spleen cells</topic><topic>STRAINS</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>Tumor Cells, Cultured</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Vaccines, Synthetic - administration & dosage</topic><topic>Vaccines, Synthetic - immunology</topic><topic>VECTEUR DE MALADIE</topic><topic>VECTORES</topic><topic>VECTORS</topic><topic>Viral Core Proteins - immunology</topic><topic>Viral Core Proteins - metabolism</topic><topic>Viral vaccines</topic><topic>Viral Vaccines - immunology</topic><topic>Virology</topic><topic>Virus-vector relationships</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Russmann, H. 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Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Russmann, H. (State University of New York at Stony Brook, Stony Brook, NY.)</au><au>Shams, H</au><au>Poblete, F</au><au>Fu, Y</au><au>Galan, J.E</au><au>Donis, R.O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delivery of epitopes by the Salmonella type III secretion system for vaccine development</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1998-07-24</date><risdate>1998</risdate><volume>281</volume><issue>5376</issue><spage>565</spage><epage>568</epage><pages>565-568</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Avirulent strains of Salmonella typhimurium are being considered as antigen delivery vectors. During its intracellular stage in the host, S. typhimurium resides within a membrane-bound compartment and is not an efficient inducer of class I-restricted immune responses. Viral epitopes were successfully delivered to the host-cell cytosol by using the type III protein secretion system of S. typhimurium. This resulted in class restricted immune responses that protected vaccinated animals against lethal infection. This approach may allow the efficient use of S. typhimurium as an antigen delivery system to control infections by pathogens that require this type of immune response for protection</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>9677200</pmid><doi>10.1126/science.281.5376.565</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1998-07, Vol.281 (5376), p.565-568 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80034498 |
| source | Jstor Complete Legacy; MEDLINE; Science Magazine |
| subjects | Animals ANTIGEN DELIVERY VECTORS Antigen Presentation ANTIGENE ANTIGENOS ANTIGENS Antigens, Viral - immunology Antigens, Viral - metabolism Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Biological and medical sciences Cytosol Cytosol - immunology Delivery Systems Endoplasmic Reticulum - immunology Endoplasmic Reticulum - metabolism Epithelial cells Epitopes Epitopes - immunology Feedback (Response) Fundamental and applied biological sciences. Psychology Health aspects Histocompatibility Antigens Class I - immunology Hybridomas IMMUNE RESPONSE Immune system Immunology Infections Lymphocytic Choriomeningitis - prevention & control Lymphocytic choriomeningitis virus - immunology Mice Mice, Inbred C57BL Microbiology Nucleoproteins - immunology Nucleoproteins - metabolism Orthomyxoviridae Peptide Fragments - immunology Peptide Fragments - metabolism Plasmids Protein Tyrosine Phosphatases - genetics Protein Tyrosine Phosphatases - metabolism Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - metabolism REPONSE IMMUNITAIRE RESPUESTA INMUNOLOGICA Salmonella SALMONELLA TYPHIMURIUM Salmonella typhimurium - metabolism Salmonella typhimurium - pathogenicity Secretion Spleen cells STRAINS T lymphocytes T-Lymphocytes - immunology T-Lymphocytes, Cytotoxic - immunology Tumor Cells, Cultured Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - immunology VECTEUR DE MALADIE VECTORES VECTORS Viral Core Proteins - immunology Viral Core Proteins - metabolism Viral vaccines Viral Vaccines - immunology Virology Virus-vector relationships |
| title | Delivery of epitopes by the Salmonella type III secretion system for vaccine development |
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