Guanosine 5′‐(γ‐[35S]Thio)triphosphate Autoradiography Allows Selective Detection of Histamine H3 Receptor‐Dependent G Protein Activation in Rat Brain Tissue Sections

: Histamine elicits its biological effects via three distinct G protein‐coupled receptors, termed H1, H2, and H3. We have used guanosine 5′‐(γ‐[35S]thio)triphosphate (GTPγ[35S]) autoradiography to localize histamine receptor‐dependent G protein activation in rat brain tissue sections. Initial studie...

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Veröffentlicht in:	Journal of neurochemistry 1998-08, Vol.71 (2), p.808-816
Hauptverfasser:	Laitinen, Jarmo T., Jokinen, Marianne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - pharmacology Adenosine A1 receptors Animals Autoradiography Basal ganglia Basal Ganglia - chemistry Basal Ganglia - metabolism Biological and medical sciences Brain Chemistry - physiology Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebral Cortex - chemistry Cerebral Cortex - metabolism Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - metabolism Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Guanosine Diphosphate - pharmacology Histamine - pharmacology Histamine Antagonists - pharmacology Histamine H1 Antagonists - pharmacology Histamine H3 receptors Male Piperidines - pharmacology Protein Binding - drug effects Pyrilamine - pharmacology Rats Rats, Wistar Receptors, Histamine H3 - metabolism Receptor‐G protein coupling Signal Transduction - drug effects Signal Transduction - physiology Substantia nigra Substantia Nigra - chemistry Substantia Nigra - metabolism Sulfur Radioisotopes Vertebrates: nervous system and sense organs Xanthines - pharmacology
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