Inhibition of neutrophil migration by tumor necrosis factor. Ex vivo and in vivo studies in comparison with in vitro effect
Coincubation of neutrophils with TNF inhibited the chemoattractant-directed migration of neutrophils under agarose and enhanced their migration in the multiwell chemotaxis chamber. To assess the physiological significance of these differing in vitro TNF effects, ex vivo and in vivo investigations we...
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| Veröffentlicht in: | The Journal of immunology (1950) 1990-10, Vol.145 (8), p.2639-2643 |
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| container_end_page | 2643 |
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| container_issue | 8 |
| container_start_page | 2639 |
| container_title | The Journal of immunology (1950) |
| container_volume | 145 |
| creator | Otsuka, Y Nagano, K Hori, K Oh-ishi, J Hayashi, H Watanabe, N Niitsu, Y |
| description | Coincubation of neutrophils with TNF inhibited the chemoattractant-directed migration of neutrophils under agarose and enhanced their migration in the multiwell chemotaxis chamber. To assess the physiological significance of these differing in vitro TNF effects, ex vivo and in vivo investigations were performed using animal models. Neutrophils from the peripheral blood of rabbits preadministered systemic TNF showed impaired ability to migrate toward chemoattractants in vitro. In addition, systemic TNF administration suppressed zymosan-activated plasma-induced local accumulation of leukocytes in mouse skin. The results indicate that circulating TNF may act as a suppressor for local inflammatory reaction. |
| doi_str_mv | 10.4049/jimmunol.145.8.2639 |
| format | Article |
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Ex vivo and in vivo studies in comparison with in vitro effect</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>Coincubation of neutrophils with TNF inhibited the chemoattractant-directed migration of neutrophils under agarose and enhanced their migration in the multiwell chemotaxis chamber. To assess the physiological significance of these differing in vitro TNF effects, ex vivo and in vivo investigations were performed using animal models. Neutrophils from the peripheral blood of rabbits preadministered systemic TNF showed impaired ability to migrate toward chemoattractants in vitro. In addition, systemic TNF administration suppressed zymosan-activated plasma-induced local accumulation of leukocytes in mouse skin. The results indicate that circulating TNF may act as a suppressor for local inflammatory reaction.</description><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemotaxis, Leukocyte - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>In Vitro Techniques</subject><subject>Inflammation - physiopathology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Miscellaneous</subject><subject>Neutrophils - physiology</subject><subject>Peroxidase - metabolism</subject><subject>Rabbits</subject><subject>Recombinant Proteins</subject><subject>Regulatory factors and their cellular receptors</subject><subject>Sepharose</subject><subject>Skin - cytology</subject><subject>Time Factors</subject><subject>Tumor Necrosis Factor-alpha - pharmacology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EKkvhCRCSD4ieNowdO06OqCqlUiUucLZmHbtxlcSLnTRUvDwOWSpunGzPfPNZ9k_IWwaFANF8vPfDMI-hL5iQRV3wqmyekR2TEvZVBdVzsgPgfM9UpV6SVyndA0AFXJyRM84USM535NfN2PmDn3wYaXB0tPMUw7HzPR38XcQ_9cMjneYhxNw1MSSfqEMzhVjQq5_0wT8EimNL_bjt0zS33qb1bMJwxOhTdix-6jYk-6l1zprpNXnhsE_2zWk9J98_X327_LK__Xp9c_npdm9KpZq9aQ0TiLKWBoVyuchrLLlwtjm0UimF2Ob31KWtBMiaYQMm66FyDhhXWJ6TD5v3GMOP2aZJDz4Z2_c42jAnXQOUpYDmvyCTDZMliAyWG7j-R4rW6WP0A8ZHzUCv2ei_2eicja71mk2eenfSz4fBtk8zpzBy__2pj8lg7yKOxqcnTEhWNc2qudiwzt91i49WpwH7PkuZXpblnwt_Awu_qPk</recordid><startdate>19901015</startdate><enddate>19901015</enddate><creator>Otsuka, Y</creator><creator>Nagano, K</creator><creator>Hori, K</creator><creator>Oh-ishi, J</creator><creator>Hayashi, H</creator><creator>Watanabe, N</creator><creator>Niitsu, Y</creator><general>Am Assoc Immnol</general><general>American Association of Immunologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19901015</creationdate><title>Inhibition of neutrophil migration by tumor necrosis factor. 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| ispartof | The Journal of immunology (1950), 1990-10, Vol.145 (8), p.2639-2643 |
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| subjects | Analysis of the immune response. Humoral and cellular immunity Animals Biological and medical sciences Chemotaxis, Leukocyte - drug effects Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology In Vitro Techniques Inflammation - physiopathology Mice Mice, Inbred BALB C Miscellaneous Neutrophils - physiology Peroxidase - metabolism Rabbits Recombinant Proteins Regulatory factors and their cellular receptors Sepharose Skin - cytology Time Factors Tumor Necrosis Factor-alpha - pharmacology |
| title | Inhibition of neutrophil migration by tumor necrosis factor. Ex vivo and in vivo studies in comparison with in vitro effect |
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