Echoviruses include genetically distinct serotypes
Department of Virology, University of Turku, Kiinamyllynkatu 13, SF-20520 Turku, Finland We have studied the genetic relationships of echoviruses using nucleotide sequencing and hybridization analysis. The nucleotide sequence of the echovirus 11 (EV11) P2 and P3 regions, which encode the nonstructur...
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| Veröffentlicht in: | Journal of general virology 1990-09, Vol.71 (9), p.2133-2139 |
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| container_title | Journal of general virology |
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| creator | Auvinen, Petri Hyypia, Timo |
| description | Department of Virology, University of Turku, Kiinamyllynkatu 13, SF-20520 Turku, Finland
We have studied the genetic relationships of echoviruses using nucleotide sequencing and hybridization analysis. The nucleotide sequence of the echovirus 11 (EV11) P2 and P3 regions, which encode the nonstructural proteins, was shown to resemble closely those of coxsackie B viruses (CBV) and coxsackievirus A9 (CAV9). EV11, CBV and CAV9 have a similar organization in the 3' non-coding region when compared to polioviruses and CAV21. In contrast, the 3' end of EV22 shares only minimal sequence homology with other sequenced enteroviruses, and the 3' non-coding region has a unique secondary structure. Thirty-three echovirus reference strains were tested by nucleic acid hybridization using cDNA probes from the genomes of EV6, 11, 18 and 22. It was shown that a great majority of the strains belongs to the same subgroup as serotypes 6, 11 and 18, whereas EV22 and EV23 are genetically not closely related to this major subgroup.
Received 29 January 1990;
accepted 9 May 1990. |
| doi_str_mv | 10.1099/0022-1317-71-9-2133 |
| format | Article |
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We have studied the genetic relationships of echoviruses using nucleotide sequencing and hybridization analysis. The nucleotide sequence of the echovirus 11 (EV11) P2 and P3 regions, which encode the nonstructural proteins, was shown to resemble closely those of coxsackie B viruses (CBV) and coxsackievirus A9 (CAV9). EV11, CBV and CAV9 have a similar organization in the 3' non-coding region when compared to polioviruses and CAV21. In contrast, the 3' end of EV22 shares only minimal sequence homology with other sequenced enteroviruses, and the 3' non-coding region has a unique secondary structure. Thirty-three echovirus reference strains were tested by nucleic acid hybridization using cDNA probes from the genomes of EV6, 11, 18 and 22. It was shown that a great majority of the strains belongs to the same subgroup as serotypes 6, 11 and 18, whereas EV22 and EV23 are genetically not closely related to this major subgroup.
Received 29 January 1990;
accepted 9 May 1990.</description><identifier>ISSN: 0022-1317</identifier><identifier>EISSN: 1465-2099</identifier><identifier>DOI: 10.1099/0022-1317-71-9-2133</identifier><identifier>PMID: 2170575</identifier><identifier>CODEN: JGVIAY</identifier><language>eng</language><publisher>Reading: Soc General Microbiol</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; Biological and medical sciences ; Capsid - genetics ; Capsid Proteins ; Cell Line ; Chromosome Mapping ; Cloning, Molecular ; Enterovirus - genetics ; Enterovirus B, Human - classification ; Enterovirus B, Human - genetics ; Fundamental and applied biological sciences. Psychology ; Genes, Viral ; Genetics ; Microbiology ; Molecular Sequence Data ; Neutralization Tests ; Nucleic Acid Conformation ; Nucleic Acid Hybridization ; Poliovirus - genetics ; RNA, Viral - genetics ; Serotyping ; Viral Core Proteins - genetics ; Viral Nonstructural Proteins ; Viral Proteins - genetics ; Virology</subject><ispartof>Journal of general virology, 1990-09, Vol.71 (9), p.2133-2139</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-a31ee3711e3048ecb90f6eb66fb75800cbb32e3d88a4943e3c768b6fd4d6dcb03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3744,3745,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19304842$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2170575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Auvinen, Petri</creatorcontrib><creatorcontrib>Hyypia, Timo</creatorcontrib><title>Echoviruses include genetically distinct serotypes</title><title>Journal of general virology</title><addtitle>J Gen Virol</addtitle><description>Department of Virology, University of Turku, Kiinamyllynkatu 13, SF-20520 Turku, Finland
We have studied the genetic relationships of echoviruses using nucleotide sequencing and hybridization analysis. The nucleotide sequence of the echovirus 11 (EV11) P2 and P3 regions, which encode the nonstructural proteins, was shown to resemble closely those of coxsackie B viruses (CBV) and coxsackievirus A9 (CAV9). EV11, CBV and CAV9 have a similar organization in the 3' non-coding region when compared to polioviruses and CAV21. In contrast, the 3' end of EV22 shares only minimal sequence homology with other sequenced enteroviruses, and the 3' non-coding region has a unique secondary structure. Thirty-three echovirus reference strains were tested by nucleic acid hybridization using cDNA probes from the genomes of EV6, 11, 18 and 22. It was shown that a great majority of the strains belongs to the same subgroup as serotypes 6, 11 and 18, whereas EV22 and EV23 are genetically not closely related to this major subgroup.
Received 29 January 1990;
accepted 9 May 1990.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Capsid - genetics</subject><subject>Capsid Proteins</subject><subject>Cell Line</subject><subject>Chromosome Mapping</subject><subject>Cloning, Molecular</subject><subject>Enterovirus - genetics</subject><subject>Enterovirus B, Human - classification</subject><subject>Enterovirus B, Human - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, Viral</subject><subject>Genetics</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Neutralization Tests</subject><subject>Nucleic Acid Conformation</subject><subject>Nucleic Acid Hybridization</subject><subject>Poliovirus - genetics</subject><subject>RNA, Viral - genetics</subject><subject>Serotyping</subject><subject>Viral Core Proteins - genetics</subject><subject>Viral Nonstructural Proteins</subject><subject>Viral Proteins - genetics</subject><subject>Virology</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctOwzAQRS0EKqXwBQipGxCbgCd24niJqvKQKrGBtRU7k9Yoj2InoP49jhq1S1aWPGeuZ44JuQb6AFTKR0rjOAIGIhIQySgGxk7IFHiaRHGon5LpgTgnF95_UQqcJ2JCJjEImohkSuKl2bQ_1vUe_dw2puoLnK-xwc6avKp288L6Ltx3c4-u7XZb9JfkrMwrj1fjOSOfz8uPxWu0en95WzytIsOZ7KKcASITAMgoz9BoScsUdZqWWiQZpUZrFiMrsiznkjNkRqSZTsuCF2lhNGUzcrfP3br2u0ffqdp6g1WVN9j2XoUMxiD7H4SwKQQtAWR70LjWe4el2jpb526ngKpBqRqEqUGYEqCkGpSGrpsxvtc1Foee0WGo34713AdnpcsbY_0xWg778zhw93tuY9ebX-tQBc-1DbNo26rwB8cn_wDvhYwr</recordid><startdate>19900901</startdate><enddate>19900901</enddate><creator>Auvinen, Petri</creator><creator>Hyypia, Timo</creator><general>Soc General Microbiol</general><general>Society for General Microbiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19900901</creationdate><title>Echoviruses include genetically distinct serotypes</title><author>Auvinen, Petri ; Hyypia, Timo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-a31ee3711e3048ecb90f6eb66fb75800cbb32e3d88a4943e3c768b6fd4d6dcb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Capsid - genetics</topic><topic>Capsid Proteins</topic><topic>Cell Line</topic><topic>Chromosome Mapping</topic><topic>Cloning, Molecular</topic><topic>Enterovirus - genetics</topic><topic>Enterovirus B, Human - classification</topic><topic>Enterovirus B, Human - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, Viral</topic><topic>Genetics</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>Neutralization Tests</topic><topic>Nucleic Acid Conformation</topic><topic>Nucleic Acid Hybridization</topic><topic>Poliovirus - genetics</topic><topic>RNA, Viral - genetics</topic><topic>Serotyping</topic><topic>Viral Core Proteins - genetics</topic><topic>Viral Nonstructural Proteins</topic><topic>Viral Proteins - genetics</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Auvinen, Petri</creatorcontrib><creatorcontrib>Hyypia, Timo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Auvinen, Petri</au><au>Hyypia, Timo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Echoviruses include genetically distinct serotypes</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>1990-09-01</date><risdate>1990</risdate><volume>71</volume><issue>9</issue><spage>2133</spage><epage>2139</epage><pages>2133-2139</pages><issn>0022-1317</issn><eissn>1465-2099</eissn><coden>JGVIAY</coden><abstract>Department of Virology, University of Turku, Kiinamyllynkatu 13, SF-20520 Turku, Finland
We have studied the genetic relationships of echoviruses using nucleotide sequencing and hybridization analysis. The nucleotide sequence of the echovirus 11 (EV11) P2 and P3 regions, which encode the nonstructural proteins, was shown to resemble closely those of coxsackie B viruses (CBV) and coxsackievirus A9 (CAV9). EV11, CBV and CAV9 have a similar organization in the 3' non-coding region when compared to polioviruses and CAV21. In contrast, the 3' end of EV22 shares only minimal sequence homology with other sequenced enteroviruses, and the 3' non-coding region has a unique secondary structure. Thirty-three echovirus reference strains were tested by nucleic acid hybridization using cDNA probes from the genomes of EV6, 11, 18 and 22. It was shown that a great majority of the strains belongs to the same subgroup as serotypes 6, 11 and 18, whereas EV22 and EV23 are genetically not closely related to this major subgroup.
Received 29 January 1990;
accepted 9 May 1990.</abstract><cop>Reading</cop><pub>Soc General Microbiol</pub><pmid>2170575</pmid><doi>10.1099/0022-1317-71-9-2133</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Microbiology Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Animals Base Sequence Biological and medical sciences Capsid - genetics Capsid Proteins Cell Line Chromosome Mapping Cloning, Molecular Enterovirus - genetics Enterovirus B, Human - classification Enterovirus B, Human - genetics Fundamental and applied biological sciences. Psychology Genes, Viral Genetics Microbiology Molecular Sequence Data Neutralization Tests Nucleic Acid Conformation Nucleic Acid Hybridization Poliovirus - genetics RNA, Viral - genetics Serotyping Viral Core Proteins - genetics Viral Nonstructural Proteins Viral Proteins - genetics Virology |
| title | Echoviruses include genetically distinct serotypes |
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