Effects of dizocilpine (MK-801) on motor activity and memory

The effects of MK-801 upon motor activity and memory were assessed in a novel use of open-field behavior testing. In this study, rats were treated with different doses of MK-801 (0.025, 0.05, 0.1 and 0.2 mg/kg) and given a brief 10-min exposure to an open-field in which locomotor activity and within...

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Veröffentlicht in:	Psychopharmacologia 1998-06, Vol.137 (3), p.241-246
Hauptverfasser:	CAREY, R. J, DAI, H, GUI, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Dizocilpine Dizocilpine Maleate - pharmacology Dose-Response Relationship, Drug Drug dosages Drug toxicity and drugs side effects treatment Excitatory Amino Acid Antagonists - pharmacology Habituation Habituation, Psychophysiologic - drug effects Locomotor activity Male Medical sciences Mental Recall - drug effects Miscellaneous (drug allergy, mutagens, teratogens...) Motor activity Motor Activity - drug effects Open-field behavior Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - drug effects Retention (Psychology) - drug effects Social Environment
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