Glial Cell Line‐Derived Neurotrophic Growth Factor Inhibits Apoptotic Death of Postnatal Substantia Nigra Dopamine Neurons in Primary Culture

: Glial cell line‐derived neurotrophic factor (GDNF) was identified on the basis of its ability to enhance the development of embryonic mesencephalic dopamine neurons. It remains unknown whether GDNF is a physiologically relevant trophic factor for these neurons. We have shown that natural cell deat...

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Veröffentlicht in:	Journal of neurochemistry 1998-08, Vol.71 (2), p.517-525
Hauptverfasser:	Burke, Robert E., Antonelli, Megan, Sulzer, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Biochemistry and metabolism Biological and medical sciences Cell Size - drug effects Cell Survival - drug effects Cells, Cultured Central nervous system Cerebral Cortex - cytology Dopamine Dopamine - physiology Female Fetus - cytology Fundamental and applied biological sciences. Psychology Glial Cell Line-Derived Neurotrophic Factor Nerve Growth Factors Nerve Tissue Proteins - pharmacology Neurons - cytology Neurons - drug effects Neurons - enzymology Neuroprotective Agents - pharmacology Parkinson's disease Pregnancy Rats Recombinant Proteins - pharmacology Substantia nigra Substantia Nigra - cytology Trophic factors Tyrosine 3-Monooxygenase - metabolism Vertebrates: nervous system and sense organs
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