Release of Telomeric DNA from Chromosomes in Immortal Human Cells Lacking Telomerase Activity

Some immortal human cell lines lack telomerase activity. These cell lines were found to contain small dispersed DNA hybridizing to TTAGGG repeats. Such DNA was located in their cytoplasm and nuclei. Normal human fibroblasts or telomerase-positive cell lines did not contain such DNA. Upon cloning and...

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Veröffentlicht in:	Biochemical and biophysical research communications 1998-07, Vol.248 (2), p.223-227
Hauptverfasser:	Ogino, Hideki, Nakabayashi, Kazuhiko, Suzuki, Mikio, Takahashi, Ei-ichi, Fujii, Michihiko, Suzuki, Toshikazu, Ayusawa, Dai
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Chromosomes - genetics Cloning, Molecular DNA - chemistry DNA, Circular - genetics Electrophoresis, Agar Gel Humans Nucleic Acid Conformation Nucleic Acid Hybridization Repetitive Sequences, Nucleic Acid - genetics Sequence Analysis, DNA Telomere - genetics
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