Growth factors for human fibroblasts in the solute remaining after clot formation

Fibroblasts adhere to, and readily grow into, fibrin clots that form as a result of the cleavage of fibrinogen by thrombin. Subsequent fibroblast replication is believed to be stimulated by mitogens released by entrapped platelets, such as platelet-derived growth factor. We suggest that the supernat...

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Veröffentlicht in:	Journal of cell science 1990-06, Vol.96 ( Pt 2) (2), p.271-274
Hauptverfasser:	Gray, A J, Reeves, J T, Harrison, N K, Winlove, P, Laurent, G J
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Coagulation - physiology Cell Division - physiology Cell Line Chromatography, Gel Fibrin - metabolism Fibrin - physiology Fibrinopeptide A - physiology Fibrinopeptide B - physiology Fibroblasts - cytology Fibroblasts - physiology Growth Substances - physiology Humans Lung - cytology Thrombin - metabolism Thrombin - physiology
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