Opioid activity of alkaloids extracted from Picralima nitida (fam. Apocynaceae)

Extracts of the seeds of Picralima nitida (fam. Apocynaceae) have been reported to have opioid analgesic activity. In this investigation, isolated tissue bioassays and radioligand binding assays have been used to determine the opioid activity of five alkaloids—akuammidine, akuammine, akuammicine, ak...

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Veröffentlicht in:	European journal of pharmacology 1998-05, Vol.350 (1), p.101-108
Hauptverfasser:	Menzies, John R.W, Paterson, Stewart J, Duwiejua, Mahama, Corbett, Alistair D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloid Alkaloids - pharmacokinetics Alkaloids - pharmacology Animals Binding assay Bioassay Biological and medical sciences Biological Assay General pharmacology Guinea Pigs Male Medical sciences Mice Narcotics - pharmacology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Opioid receptor ORL 1-receptor Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Picralima nitida Plants, Medicinal - chemistry Rabbits Radioligand Assay Receptors, Opioid - drug effects Receptors, Opioid - metabolism
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