N-(4-hydroxyphenyl)retinamide-induced death in human lymphoblastoid cells: 50 kb DNA breakage as a means of distinguishing apoptosis from necrosis

Experimental studies of N-(4-hydroxyphenyl)retinamide, a potential cancer chemopreventive agent, have primarily involved breast cancer and neuroblastoma cell populations together with an investigation of myeloid leukemia cells and have principally been concerned with the induction of apoptosis. This...

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Veröffentlicht in:	Cancer letters 1998-06, Vol.128 (2), p.189-196
Hauptverfasser:	Springer, Lisa N, Stewart, Bernard W
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticarcinogenic Agents - pharmacology Antineoplastic agents Apoptosis Apoptosis - drug effects Biological and medical sciences Cell Cycle - drug effects Cell Death - drug effects Cell Membrane - drug effects Cell Membrane - metabolism Cell Membrane Permeability - drug effects Chemotherapy DNA Damage DNA, Neoplasm - drug effects DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Fenretinide - pharmacology Flow Cytometry Humans Leukemia, T-Cell - drug therapy Leukemia, T-Cell - metabolism Leukemia, T-Cell - pathology Lymphoblastoid cell Medical sciences N-(4-Hydroxyphenyl)retinamide Necrosis Pharmacology. Drug treatments Pulsed-field electrophoresis
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