Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl
The Rho small G protein family, consisting of the Rho, Rac, and Cdc42 subfamilies, regulates various actin cytoskeleton-dependent cell functions. The Rho subfamily members regulate ERM (ezrin, radixin and moesin)-dependent association of the actin cytoskeleton with the plasma membrane. Moreover, the...
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| Veröffentlicht in: | Oncogene 1998-06, Vol.16 (25), p.3279-3284 |
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| creator | TAKAHASHI, K SASAKI, T MAMMOTO, A HOTTA, I TAKAISHI, K IMAMURA, H NAKANO, K KODAMA, A TAKAI, Y |
| description | The Rho small G protein family, consisting of the Rho, Rac, and Cdc42 subfamilies, regulates various actin cytoskeleton-dependent cell functions. The Rho subfamily members regulate ERM (ezrin, radixin and moesin)-dependent association of the actin cytoskeleton with the plasma membrane. Moreover, the N-terminal regions of ERM interact with Rho GDI, an inhibitory regulator of all the Rho family members, and reduce its inhibitory action, finally initiating the activation of the Rho family members. We show here that the N-terminal region of radixin furthermore interacts with Dbl, a stimulatory GDP/GTP exchange protein of the Rho family members. This interaction does not affect the Dbl activity to stimulate the GDP/GTP exchange reaction of RhoA, a member of the Rho subfamily. Dbl does not interact with radixin which is precomplexed with Rho GDI, and Rho GDI displaces Dbl from radixin. Thus, radixin plays an important role in activation of the Rho family members by recruiting their positive and negative regulators. |
| doi_str_mv | 10.1038/sj.onc.1201874 |
| format | Article |
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The Rho subfamily members regulate ERM (ezrin, radixin and moesin)-dependent association of the actin cytoskeleton with the plasma membrane. Moreover, the N-terminal regions of ERM interact with Rho GDI, an inhibitory regulator of all the Rho family members, and reduce its inhibitory action, finally initiating the activation of the Rho family members. We show here that the N-terminal region of radixin furthermore interacts with Dbl, a stimulatory GDP/GTP exchange protein of the Rho family members. This interaction does not affect the Dbl activity to stimulate the GDP/GTP exchange reaction of RhoA, a member of the Rho subfamily. Dbl does not interact with radixin which is precomplexed with Rho GDI, and Rho GDI displaces Dbl from radixin. Thus, radixin plays an important role in activation of the Rho family members by recruiting their positive and negative regulators.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/sj.onc.1201874</identifier><identifier>PMID: 9681826</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Actin ; Binding Sites ; Biological and medical sciences ; Blood Proteins - chemistry ; Blood Proteins - metabolism ; Cdc42 protein ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Cytoskeletal Proteins ; Cytoskeleton ; DNA-Binding Proteins - chemistry ; DNA-Binding Proteins - metabolism ; Ezrin ; Fundamental and applied biological sciences. Psychology ; GDP/GTP exchange protein ; Glutathione Transferase - chemistry ; Glutathione Transferase - metabolism ; GTP-Binding Proteins - chemistry ; GTP-Binding Proteins - metabolism ; Guanine Nucleotide Dissociation Inhibitors ; Guanosine diphosphate ; Guanosine Diphosphate - chemistry ; Guanosine Diphosphate - metabolism ; Guanosine triphosphate ; Guanosine Triphosphate - chemistry ; Guanosine Triphosphate - metabolism ; Membrane Proteins - chemistry ; Membrane Proteins - metabolism ; Moesin ; Molecular and cellular biology ; Peptide Fragments - chemistry ; Peptide Fragments - metabolism ; Protein Binding ; Proteins ; Radixin ; Retroviridae Proteins, Oncogenic - chemistry ; Retroviridae Proteins, Oncogenic - metabolism ; Rho Factor - chemistry ; Rho Factor - metabolism ; rho-Specific Guanine Nucleotide Dissociation Inhibitors ; RhoA protein ; Transcription Factors - chemistry ; Transcription Factors - metabolism</subject><ispartof>Oncogene, 1998-06, Vol.16 (25), p.3279-3284</ispartof><rights>1998 INIST-CNRS</rights><rights>Macmillan Publishers Limited 1998.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-5334757729fe10dd1cbb57434158af3cc2bec2dd2732b4103a1ffd44f1afdc143</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2320381$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9681826$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TAKAHASHI, K</creatorcontrib><creatorcontrib>SASAKI, T</creatorcontrib><creatorcontrib>MAMMOTO, A</creatorcontrib><creatorcontrib>HOTTA, I</creatorcontrib><creatorcontrib>TAKAISHI, K</creatorcontrib><creatorcontrib>IMAMURA, H</creatorcontrib><creatorcontrib>NAKANO, K</creatorcontrib><creatorcontrib>KODAMA, A</creatorcontrib><creatorcontrib>TAKAI, Y</creatorcontrib><title>Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl</title><title>Oncogene</title><addtitle>Oncogene</addtitle><description>The Rho small G protein family, consisting of the Rho, Rac, and Cdc42 subfamilies, regulates various actin cytoskeleton-dependent cell functions. The Rho subfamily members regulate ERM (ezrin, radixin and moesin)-dependent association of the actin cytoskeleton with the plasma membrane. Moreover, the N-terminal regions of ERM interact with Rho GDI, an inhibitory regulator of all the Rho family members, and reduce its inhibitory action, finally initiating the activation of the Rho family members. We show here that the N-terminal region of radixin furthermore interacts with Dbl, a stimulatory GDP/GTP exchange protein of the Rho family members. This interaction does not affect the Dbl activity to stimulate the GDP/GTP exchange reaction of RhoA, a member of the Rho subfamily. Dbl does not interact with radixin which is precomplexed with Rho GDI, and Rho GDI displaces Dbl from radixin. Thus, radixin plays an important role in activation of the Rho family members by recruiting their positive and negative regulators.</description><subject>Actin</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - chemistry</subject><subject>Blood Proteins - metabolism</subject><subject>Cdc42 protein</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Cytoskeletal Proteins</subject><subject>Cytoskeleton</subject><subject>DNA-Binding Proteins - chemistry</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Ezrin</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GDP/GTP exchange protein</subject><subject>Glutathione Transferase - chemistry</subject><subject>Glutathione Transferase - metabolism</subject><subject>GTP-Binding Proteins - chemistry</subject><subject>GTP-Binding Proteins - metabolism</subject><subject>Guanine Nucleotide Dissociation Inhibitors</subject><subject>Guanosine diphosphate</subject><subject>Guanosine Diphosphate - chemistry</subject><subject>Guanosine Diphosphate - metabolism</subject><subject>Guanosine triphosphate</subject><subject>Guanosine Triphosphate - chemistry</subject><subject>Guanosine Triphosphate - metabolism</subject><subject>Membrane Proteins - chemistry</subject><subject>Membrane Proteins - metabolism</subject><subject>Moesin</subject><subject>Molecular and cellular biology</subject><subject>Peptide Fragments - chemistry</subject><subject>Peptide Fragments - metabolism</subject><subject>Protein Binding</subject><subject>Proteins</subject><subject>Radixin</subject><subject>Retroviridae Proteins, Oncogenic - chemistry</subject><subject>Retroviridae Proteins, Oncogenic - metabolism</subject><subject>Rho Factor - chemistry</subject><subject>Rho Factor - metabolism</subject><subject>rho-Specific Guanine Nucleotide Dissociation Inhibitors</subject><subject>RhoA protein</subject><subject>Transcription Factors - chemistry</subject><subject>Transcription Factors - metabolism</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLAzEUhYMotVa37oQBxd20eU4yS2m1FgoWqeuQySR2hnnUZIr135vSoQs3ru7ifPcc7j0A3CI4RpCIiS_HbaPHCEMkOD0DQ0R5EjOW0nMwhCmDcYoJvgRX3pcQQp5CPACDNBFI4GQIloumM07prmibqLWRU3mxL5rou-g20fumjXytqiqaR1vXdiYI89lqMl-vIrPXG9V8mpMwy6prcGFV5c1NP0fg4-V5PX2Nl2_zxfRpGWvCRRczQihnnOPUGgTzHOksY5wSiphQlmiNM6NxnmNOcEbDlQpZm1NqkbK5RpSMwOPRN2R_7YzvZF14bapKNabdeSkgxClPkn9BlDAGRYIDeP8HLNuda8IREicUEShSfMgdHyntWu-dsXLrilq5H4mgPLQhfSlDG7JvIyzc9ba7rDb5Ce_fH_SHXldeq8o61ejCn7BQXDBF5BdGOZDV</recordid><startdate>19980625</startdate><enddate>19980625</enddate><creator>TAKAHASHI, K</creator><creator>SASAKI, T</creator><creator>MAMMOTO, A</creator><creator>HOTTA, I</creator><creator>TAKAISHI, K</creator><creator>IMAMURA, H</creator><creator>NAKANO, K</creator><creator>KODAMA, A</creator><creator>TAKAI, Y</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19980625</creationdate><title>Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl</title><author>TAKAHASHI, K ; SASAKI, T ; MAMMOTO, A ; HOTTA, I ; TAKAISHI, K ; IMAMURA, H ; NAKANO, K ; KODAMA, A ; TAKAI, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-5334757729fe10dd1cbb57434158af3cc2bec2dd2732b4103a1ffd44f1afdc143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Actin</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>Blood Proteins - chemistry</topic><topic>Blood Proteins - metabolism</topic><topic>Cdc42 protein</topic><topic>Cell physiology</topic><topic>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</topic><topic>Cytoskeletal Proteins</topic><topic>Cytoskeleton</topic><topic>DNA-Binding Proteins - chemistry</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Ezrin</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GDP/GTP exchange protein</topic><topic>Glutathione Transferase - chemistry</topic><topic>Glutathione Transferase - metabolism</topic><topic>GTP-Binding Proteins - chemistry</topic><topic>GTP-Binding Proteins - metabolism</topic><topic>Guanine Nucleotide Dissociation Inhibitors</topic><topic>Guanosine diphosphate</topic><topic>Guanosine Diphosphate - chemistry</topic><topic>Guanosine Diphosphate - metabolism</topic><topic>Guanosine triphosphate</topic><topic>Guanosine Triphosphate - chemistry</topic><topic>Guanosine Triphosphate - metabolism</topic><topic>Membrane Proteins - chemistry</topic><topic>Membrane Proteins - metabolism</topic><topic>Moesin</topic><topic>Molecular and cellular biology</topic><topic>Peptide Fragments - chemistry</topic><topic>Peptide Fragments - metabolism</topic><topic>Protein Binding</topic><topic>Proteins</topic><topic>Radixin</topic><topic>Retroviridae Proteins, Oncogenic - chemistry</topic><topic>Retroviridae Proteins, Oncogenic - metabolism</topic><topic>Rho Factor - chemistry</topic><topic>Rho Factor - metabolism</topic><topic>rho-Specific Guanine Nucleotide Dissociation Inhibitors</topic><topic>RhoA protein</topic><topic>Transcription Factors - chemistry</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TAKAHASHI, K</creatorcontrib><creatorcontrib>SASAKI, T</creatorcontrib><creatorcontrib>MAMMOTO, A</creatorcontrib><creatorcontrib>HOTTA, I</creatorcontrib><creatorcontrib>TAKAISHI, K</creatorcontrib><creatorcontrib>IMAMURA, H</creatorcontrib><creatorcontrib>NAKANO, K</creatorcontrib><creatorcontrib>KODAMA, A</creatorcontrib><creatorcontrib>TAKAI, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TAKAHASHI, K</au><au>SASAKI, T</au><au>MAMMOTO, A</au><au>HOTTA, I</au><au>TAKAISHI, K</au><au>IMAMURA, H</au><au>NAKANO, K</au><au>KODAMA, A</au><au>TAKAI, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl</atitle><jtitle>Oncogene</jtitle><addtitle>Oncogene</addtitle><date>1998-06-25</date><risdate>1998</risdate><volume>16</volume><issue>25</issue><spage>3279</spage><epage>3284</epage><pages>3279-3284</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><abstract>The Rho small G protein family, consisting of the Rho, Rac, and Cdc42 subfamilies, regulates various actin cytoskeleton-dependent cell functions. The Rho subfamily members regulate ERM (ezrin, radixin and moesin)-dependent association of the actin cytoskeleton with the plasma membrane. Moreover, the N-terminal regions of ERM interact with Rho GDI, an inhibitory regulator of all the Rho family members, and reduce its inhibitory action, finally initiating the activation of the Rho family members. We show here that the N-terminal region of radixin furthermore interacts with Dbl, a stimulatory GDP/GTP exchange protein of the Rho family members. This interaction does not affect the Dbl activity to stimulate the GDP/GTP exchange reaction of RhoA, a member of the Rho subfamily. Dbl does not interact with radixin which is precomplexed with Rho GDI, and Rho GDI displaces Dbl from radixin. Thus, radixin plays an important role in activation of the Rho family members by recruiting their positive and negative regulators.</abstract><cop>Basingstoke</cop><pub>Nature Publishing</pub><pmid>9681826</pmid><doi>10.1038/sj.onc.1201874</doi><tpages>6</tpages></addata></record> |
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| ispartof | Oncogene, 1998-06, Vol.16 (25), p.3279-3284 |
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| source | MEDLINE; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerNature Journals |
| subjects | Actin Binding Sites Biological and medical sciences Blood Proteins - chemistry Blood Proteins - metabolism Cdc42 protein Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cytoskeletal Proteins Cytoskeleton DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Ezrin Fundamental and applied biological sciences. Psychology GDP/GTP exchange protein Glutathione Transferase - chemistry Glutathione Transferase - metabolism GTP-Binding Proteins - chemistry GTP-Binding Proteins - metabolism Guanine Nucleotide Dissociation Inhibitors Guanosine diphosphate Guanosine Diphosphate - chemistry Guanosine Diphosphate - metabolism Guanosine triphosphate Guanosine Triphosphate - chemistry Guanosine Triphosphate - metabolism Membrane Proteins - chemistry Membrane Proteins - metabolism Moesin Molecular and cellular biology Peptide Fragments - chemistry Peptide Fragments - metabolism Protein Binding Proteins Radixin Retroviridae Proteins, Oncogenic - chemistry Retroviridae Proteins, Oncogenic - metabolism Rho Factor - chemistry Rho Factor - metabolism rho-Specific Guanine Nucleotide Dissociation Inhibitors RhoA protein Transcription Factors - chemistry Transcription Factors - metabolism |
| title | Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl |
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