Evidence That Orexigenic Effects of Melanocortin 4 Receptor Antagonist HS014 Are Mediated by Neuropeptide Y

Recent studies using melanocortin-4 receptor (MC4R) knockout mice and MC4R antagonists have shown that weakening of MC4R-ergic tone increases food intake and causes obesity. In this study, we used the newly discovered selective MC4R antagonist HS014 for increasing food intake in free-feeding rats an...

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Veröffentlicht in:	Biochemical and biophysical research communications 1998-07, Vol.248 (2), p.245-249
Hauptverfasser:	Kask, Ants, Rägo, Lembit, Korrovits, Paul, Wikberg, Jarl E.S., Schiöth, Helgi B.
Format:	Artikel
Sprache:	eng
Schlagworte:	1229U91 Animals cyclic MSH analogue Eating - drug effects Feeding Behavior - drug effects fluoxetine Fluoxetine - pharmacology food intake HS014 Hypothalamus - physiology Male MC4 antagonist Melanocortin (MC) receptor subtypes neuropeptide Y Neuropeptide Y - antagonists & inhibitors neuropeptide Y1 receptors Peptides, Cyclic - pharmacology Rats Rats, Wistar Receptor, Melanocortin, Type 4 Receptors, Corticotropin - antagonists & inhibitors Serotonin Antagonists - pharmacology Signal Transduction - physiology
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