Characterization of echoviruses that bind decay accelerating factor (CD55): evidence that some haemagglutinating strains use more than one cellular receptor
RM Powell, V Schmitt, T Ward, I Goodfellow, DJ Evans and JW Almond School of Animal and Microbial Sciences, University of Reading, Whiteknights, UK. Several echoviruses (EVs) have previously been shown to use decay accelerating factor (DAF) as a cellular receptor. Since DAF is expressed on erythrocy...
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| Veröffentlicht in: | Journal of general virology 1998-07, Vol.79 (7), p.1707-1713 |
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| container_issue | 7 |
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| container_title | Journal of general virology |
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| creator | Powell, RM Schmitt, V Ward, T Goodfellow, I Evans, DJ Almond, JW |
| description | RM Powell, V Schmitt, T Ward, I Goodfellow, DJ Evans and JW Almond
School of Animal and Microbial Sciences, University of Reading, Whiteknights, UK.
Several echoviruses (EVs) have previously been shown to use decay
accelerating factor (DAF) as a cellular receptor. Since DAF is expressed on
erythrocytes, EVs that use this receptor cause haemagglutination. Here we
show that all EVs that haemagglutinate do so via attachment to DAF and that
this interaction can be inhibited by a monoclonal antibody (MAb) specific
for DAF domain SCR3. Although the viruses haemagglutinate via DAF some can
bind to rhabdomyosarcoma cells from which DAF has been removed and infect
in the presence of a MAb against DAF. This suggests that some EVs have the
capacity to interact with more than one cellular receptor. |
| doi_str_mv | 10.1099/0022-1317-79-7-1707 |
| format | Article |
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School of Animal and Microbial Sciences, University of Reading, Whiteknights, UK.
Several echoviruses (EVs) have previously been shown to use decay
accelerating factor (DAF) as a cellular receptor. Since DAF is expressed on
erythrocytes, EVs that use this receptor cause haemagglutination. Here we
show that all EVs that haemagglutinate do so via attachment to DAF and that
this interaction can be inhibited by a monoclonal antibody (MAb) specific
for DAF domain SCR3. Although the viruses haemagglutinate via DAF some can
bind to rhabdomyosarcoma cells from which DAF has been removed and infect
in the presence of a MAb against DAF. This suggests that some EVs have the
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School of Animal and Microbial Sciences, University of Reading, Whiteknights, UK.
Several echoviruses (EVs) have previously been shown to use decay
accelerating factor (DAF) as a cellular receptor. Since DAF is expressed on
erythrocytes, EVs that use this receptor cause haemagglutination. Here we
show that all EVs that haemagglutinate do so via attachment to DAF and that
this interaction can be inhibited by a monoclonal antibody (MAb) specific
for DAF domain SCR3. Although the viruses haemagglutinate via DAF some can
bind to rhabdomyosarcoma cells from which DAF has been removed and infect
in the presence of a MAb against DAF. This suggests that some EVs have the
capacity to interact with more than one cellular receptor.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - metabolism</subject><subject>CD55 Antigens - genetics</subject><subject>CD55 Antigens - immunology</subject><subject>CD55 Antigens - metabolism</subject><subject>Cell Line</subject><subject>Echovirus 6, Human - metabolism</subject><subject>Enterovirus B, Human - metabolism</subject><subject>Hemagglutination</subject><subject>Hemagglutination Inhibition Tests</subject><subject>Humans</subject><subject>Mice</subject><subject>Phosphatidylinositol Diacylglycerol-Lyase</subject><subject>Receptors, Virus - metabolism</subject><subject>Sulfur Radioisotopes</subject><subject>Tumor Cells, Cultured</subject><subject>Type C Phospholipases - metabolism</subject><subject>Type C Phospholipases - pharmacology</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAYRS1EVYbCEyAkr1C7SGsn_onZVUP5kSqxKWvLcT4nRkk82ElR-yx9WBwyKktWXtxzry0fhN5RckmJUleElGVBKyoLqQpZUEnkC7SjTPCizPlLtHsmXqHXKf0khDLG5Sk6VaImtGI79LTvTTR2hugfzezDhIPDYPtw7-OSIOG5NzNu_NTiFqx5wMZaGCBmduqwy80Q8fn-E-cXHzHc-xYmC1sphRFwb2A0XTcsmd86aY7GTwnndTyG-BfOt06A8_CwDCbiCBYOefgNOnFmSPD2eJ6hH59v7vZfi9vvX77tr28Ly4iaC85bw03ZCAXUtaySnDS2bEXT8Lo2OaJMlUJWZo2Eg7oE5UilnKtF1bSqOkMftt1DDL8WSLMefVpfYyYIS9J1_kdRZvh_IBVMMSHrDFYbaGNIKYLTh-hHEx80JXqVp1c1elWjpdJSr_Jy6_1xfmlGaJ87R1s5P9_y3nf9bx9BdzCNPt_R-KCzsX9TfwD0AqXM</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>Powell, RM</creator><creator>Schmitt, V</creator><creator>Ward, T</creator><creator>Goodfellow, I</creator><creator>Evans, DJ</creator><creator>Almond, JW</creator><general>Soc General Microbiol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980701</creationdate><title>Characterization of echoviruses that bind decay accelerating factor (CD55): evidence that some haemagglutinating strains use more than one cellular receptor</title><author>Powell, RM ; Schmitt, V ; Ward, T ; Goodfellow, I ; Evans, DJ ; Almond, JW</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-55da5a2b69e1fd43750bc2d6bb588aa5a1492673a43756fe82e9f039ff863bd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - metabolism</topic><topic>CD55 Antigens - genetics</topic><topic>CD55 Antigens - immunology</topic><topic>CD55 Antigens - metabolism</topic><topic>Cell Line</topic><topic>Echovirus 6, Human - metabolism</topic><topic>Enterovirus B, Human - metabolism</topic><topic>Hemagglutination</topic><topic>Hemagglutination Inhibition Tests</topic><topic>Humans</topic><topic>Mice</topic><topic>Phosphatidylinositol Diacylglycerol-Lyase</topic><topic>Receptors, Virus - metabolism</topic><topic>Sulfur Radioisotopes</topic><topic>Tumor Cells, Cultured</topic><topic>Type C Phospholipases - metabolism</topic><topic>Type C Phospholipases - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Powell, RM</creatorcontrib><creatorcontrib>Schmitt, V</creatorcontrib><creatorcontrib>Ward, T</creatorcontrib><creatorcontrib>Goodfellow, I</creatorcontrib><creatorcontrib>Evans, DJ</creatorcontrib><creatorcontrib>Almond, JW</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Powell, RM</au><au>Schmitt, V</au><au>Ward, T</au><au>Goodfellow, I</au><au>Evans, DJ</au><au>Almond, JW</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of echoviruses that bind decay accelerating factor (CD55): evidence that some haemagglutinating strains use more than one cellular receptor</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>79</volume><issue>7</issue><spage>1707</spage><epage>1713</epage><pages>1707-1713</pages><issn>0022-1317</issn><eissn>1465-2099</eissn><abstract>RM Powell, V Schmitt, T Ward, I Goodfellow, DJ Evans and JW Almond
School of Animal and Microbial Sciences, University of Reading, Whiteknights, UK.
Several echoviruses (EVs) have previously been shown to use decay
accelerating factor (DAF) as a cellular receptor. Since DAF is expressed on
erythrocytes, EVs that use this receptor cause haemagglutination. Here we
show that all EVs that haemagglutinate do so via attachment to DAF and that
this interaction can be inhibited by a monoclonal antibody (MAb) specific
for DAF domain SCR3. Although the viruses haemagglutinate via DAF some can
bind to rhabdomyosarcoma cells from which DAF has been removed and infect
in the presence of a MAb against DAF. This suggests that some EVs have the
capacity to interact with more than one cellular receptor.</abstract><cop>England</cop><pub>Soc General Microbiol</pub><pmid>9680134</pmid><doi>10.1099/0022-1317-79-7-1707</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of general virology, 1998-07, Vol.79 (7), p.1707-1713 |
| issn | 0022-1317 1465-2099 |
| language | eng |
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| source | MEDLINE; Microbiology Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Antibodies, Monoclonal - metabolism CD55 Antigens - genetics CD55 Antigens - immunology CD55 Antigens - metabolism Cell Line Echovirus 6, Human - metabolism Enterovirus B, Human - metabolism Hemagglutination Hemagglutination Inhibition Tests Humans Mice Phosphatidylinositol Diacylglycerol-Lyase Receptors, Virus - metabolism Sulfur Radioisotopes Tumor Cells, Cultured Type C Phospholipases - metabolism Type C Phospholipases - pharmacology |
| title | Characterization of echoviruses that bind decay accelerating factor (CD55): evidence that some haemagglutinating strains use more than one cellular receptor |
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