One of the protein phosphatase 1 isoenzymes in Drosophila is essential for mitosis

Drosophila has four loci encoding type 1 protein serine/threonine phosphatases (PP1s). Here we describe mutations in one of these genes, at 87B on chromosome 3. Mutants die at the larval-pupal boundary with little or no imaginal cell proliferation. Neuroblasts are delayed in progress through mitosis...

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Veröffentlicht in:	Cell 1990-10, Vol.63 (1), p.33-46
Hauptverfasser:	Axton, J.Myles, Dombrádi, Vlktor, Cohen, Patricia T.W., Glover, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Chromosome Aberrations Chromosome Mapping Chromosomes - ultrastructure DNA - genetics DNA - isolation & purification Drosophila Drosophila - cytology Drosophila - enzymology Drosophila - genetics Enzymes and enzyme inhibitors Female Fundamental and applied biological sciences. Psychology Hydrolases Isoenzymes - genetics Isoenzymes - metabolism Male Mitosis Mutation Neurons - cytology Phosphoprotein Phosphatases - genetics Phosphoprotein Phosphatases - metabolism Protein Phosphatase 1 Salivary Glands - cytology Spindle Apparatus - ultrastructure Transcription, Genetic
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