Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

We have Identified a novel growth factor, stem cell factor (SCF), for primitive hematopoietic progenitors based on its activity on bone marrow cells derived from mice treated with 5-fluorouracil. The protein was isolated from the medium conditioned by Buffalo rat liver cells. It is heavily glycosyla...

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Veröffentlicht in:	Cell 1990-10, Vol.63 (1), p.195-201
Hauptverfasser:	Zsebo, Krisztina M., Wypych, Jette, McNiece, Ian K., Lu, Hsieng S., Smith, Kent A., Karkare, Subash B., Sachdev, Raj K., Yuschenkoff, Victoria N., Birkett, Neal C., Williams, Lee R., Satyagal, Vasuki N., Tung, Weifong, Bosselman, Robert A., Mendiaz, Elizabeth A., Langley, Keith E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Bone Marrow Cells Cell Division - drug effects Cells, Cultured Chromatography, Affinity Chromatography, Ion Exchange Culture Media Fluorouracil - pharmacology Fundamental and applied biological sciences. Psychology Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology growth factors Hematopoietic Cell Growth Factors - biosynthesis Hematopoietic Cell Growth Factors - isolation & purification Hematopoietic Cell Growth Factors - pharmacology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects liver Liver - physiology Mice Molecular Sequence Data Molecular Weight Protein hormones. Growth factors. Cytokines Proteins Rats Rats, Inbred BUF stem cell factor
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