Voltage-dependent action of valproate on potassium channels in frog node of Ranvier

The influence of the anti-epileptic drug, valproate, on K conductance (g K) was investigated in voltage-clamped Ranvier nodes of Xenopus laevis. A double pulse method was used in order to eliminate the effect of accumulation of potassium ions in the perinodal space, thus enabling the determination o...

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Veröffentlicht in:	European journal of pharmacology 1990-08, Vol.184 (1), p.151-161
Hauptverfasser:	Van Erp, Marinus G., Van Dongen, Antonius M.J., Van den Berg, Rutgeris J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-epileptic drugs In Vitro Techniques K + conductance Membranes - drug effects Membranes - metabolism Node of Ranvier nodes of Ranvier Potassium Channels - drug effects Ranvier's Nodes - drug effects Ranvier's Nodes - metabolism Valproate valproic acid Valproic Acid - pharmacology Voltage clamp Voltage-dependent inhibition Xenopus laevis Xenopus laevis - metabolism
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