BDNF and trkB mRNAs oscillate in rat brain during the light–dark cycle
In this study, we investigated whether in basal conditions the different functional states occurring during a 24-h cycle are reflected by the expression of brain-derived neurotrophic factor (BDNF) and its receptor, trkB, in rat cerebral cortex and hippocampus. Using semiquantitative RT-PCR assay, th...
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| Veröffentlicht in: | Brain research. Molecular brain research. 1998-06, Vol.57 (2), p.321-324 |
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| container_title | Brain research. Molecular brain research. |
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| creator | Bova, Rodolfo Micheli, Maria Rita Qualadrucci, Paolo Zucconi, Gigliola Grassi |
| description | In this study, we investigated whether in basal conditions the different functional states occurring during a 24-h cycle are reflected by the expression of brain-derived neurotrophic factor (BDNF) and its receptor,
trkB, in rat cerebral cortex and hippocampus. Using semiquantitative RT-PCR assay, the levels of both BDNF and
trkB mRNAs were found to undergo significant variation in a 24-h period. The strongest variation was detected in the hippocampus, where the ratio between maximum and minimum levels was about 3.5 and 17.5 for BDNF and
trkB, respectively. These findings provide the first evidence that, in the absence of any experimental manipulation, the expression of a neurotrophin and its receptor undergoes diurnal oscillation, possibly related to the physiological variations of the activity level. |
| doi_str_mv | 10.1016/S0169-328X(98)00092-8 |
| format | Article |
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trkB, in rat cerebral cortex and hippocampus. Using semiquantitative RT-PCR assay, the levels of both BDNF and
trkB mRNAs were found to undergo significant variation in a 24-h period. The strongest variation was detected in the hippocampus, where the ratio between maximum and minimum levels was about 3.5 and 17.5 for BDNF and
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trkB, in rat cerebral cortex and hippocampus. Using semiquantitative RT-PCR assay, the levels of both BDNF and
trkB mRNAs were found to undergo significant variation in a 24-h period. The strongest variation was detected in the hippocampus, where the ratio between maximum and minimum levels was about 3.5 and 17.5 for BDNF and
trkB, respectively. These findings provide the first evidence that, in the absence of any experimental manipulation, the expression of a neurotrophin and its receptor undergoes diurnal oscillation, possibly related to the physiological variations of the activity level.</description><subject>Animals</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Central nervous system</subject><subject>Cerebral cortex</subject><subject>Circadian Rhythm - physiology</subject><subject>Darkness</subject><subject>Frontal Lobe - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Hippocampus - metabolism</subject><subject>Light</subject><subject>Light–dark cycle</subject><subject>Male</subject><subject>Oscillometry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptor Protein-Tyrosine Kinases - genetics</subject><subject>Receptor, Ciliary Neurotrophic Factor</subject><subject>Receptors, Nerve Growth Factor - genetics</subject><subject>RT-PCR</subject><subject>Tyrosine kinase receptor</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0169-328X</issn><issn>1872-6941</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlOHDEQhi2UiAwkj4DkQxTBoRNv3e06RawhEiJSFomb5aUaHHq6we5B4sY78IZ5kniY0Vy5lEuqr8q_PkL2OPvMGW--_CoFKin01T7oA8YYiEpvkRnXragaUPwNmW2Qd2Qn578F4przbbINTVsryWbk_Ojk8ozaIdAp3R7R-c_Lw0zH7GPf2wlpHGiyE3XJli4sUhyu6XSDtI_XN9O_p-dg0y31j77H9-RtZ_uMH9bvLvlzdvr7-Ly6-PHt-_HhReVrqafKy9bVKIQU2LatdNBpFxgTUDunNAA0UtVOKu8YSgFeBgUaOQdQHQSNcpd8Wt29S-P9AvNk5jF7LHEHHBfZ6HJMqBpeBXmj2DJCAesV6NOYc8LO3KU4t-nRcGaWqs2LarP0aECbF9VGl7299QcLN8ew2Vq7LfOP67nN3vZdsoOPeYMJxVjLeMG-rjAs1h4iJlPs4-AxxIR-MmGMrwT5D7GkmUo</recordid><startdate>19980615</startdate><enddate>19980615</enddate><creator>Bova, Rodolfo</creator><creator>Micheli, Maria Rita</creator><creator>Qualadrucci, Paolo</creator><creator>Zucconi, Gigliola Grassi</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19980615</creationdate><title>BDNF and trkB mRNAs oscillate in rat brain during the light–dark cycle</title><author>Bova, Rodolfo ; Micheli, Maria Rita ; Qualadrucci, Paolo ; Zucconi, Gigliola Grassi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-c37b5e2232e7773b9f8bd00295bb489996345b34cb0e329c3d498e11994f9d8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Central nervous system</topic><topic>Cerebral cortex</topic><topic>Circadian Rhythm - physiology</topic><topic>Darkness</topic><topic>Frontal Lobe - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus</topic><topic>Hippocampus - metabolism</topic><topic>Light</topic><topic>Light–dark cycle</topic><topic>Male</topic><topic>Oscillometry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptor Protein-Tyrosine Kinases - genetics</topic><topic>Receptor, Ciliary Neurotrophic Factor</topic><topic>Receptors, Nerve Growth Factor - genetics</topic><topic>RT-PCR</topic><topic>Tyrosine kinase receptor</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bova, Rodolfo</creatorcontrib><creatorcontrib>Micheli, Maria Rita</creatorcontrib><creatorcontrib>Qualadrucci, Paolo</creatorcontrib><creatorcontrib>Zucconi, Gigliola Grassi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research. 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trkB, in rat cerebral cortex and hippocampus. Using semiquantitative RT-PCR assay, the levels of both BDNF and
trkB mRNAs were found to undergo significant variation in a 24-h period. The strongest variation was detected in the hippocampus, where the ratio between maximum and minimum levels was about 3.5 and 17.5 for BDNF and
trkB, respectively. These findings provide the first evidence that, in the absence of any experimental manipulation, the expression of a neurotrophin and its receptor undergoes diurnal oscillation, possibly related to the physiological variations of the activity level.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9675430</pmid><doi>10.1016/S0169-328X(98)00092-8</doi><tpages>4</tpages></addata></record> |
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| ispartof | Brain research. Molecular brain research., 1998-06, Vol.57 (2), p.321-324 |
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| language | eng |
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| subjects | Animals Biochemistry and metabolism Biological and medical sciences Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Central nervous system Cerebral cortex Circadian Rhythm - physiology Darkness Frontal Lobe - metabolism Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - metabolism Light Light–dark cycle Male Oscillometry Rats Rats, Wistar Receptor Protein-Tyrosine Kinases - genetics Receptor, Ciliary Neurotrophic Factor Receptors, Nerve Growth Factor - genetics RT-PCR Tyrosine kinase receptor Vertebrates: nervous system and sense organs |
| title | BDNF and trkB mRNAs oscillate in rat brain during the light–dark cycle |
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