Bombesin stimulation of c-fos expression and mitogenesis in swiss 3T3 cells : the role of prostaglandin E2-mediated cyclic AMP accumulation

Bombesin is a potent mitogen for Swiss 3T3 cells and can stimulate DNA synthesis in the absence of any other growth factor. This effect is mediated by multiple synergistic signaling pathways, including an accumulation of intracellular cyclic AMP (cAMP) and an increase in c-fos mRNA expression. The c...

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Veröffentlicht in:	Experimental cell research 1990-10, Vol.190 (2), p.265-270
Hauptverfasser:	MEHMET, H, MILLAR, J. B. A, LEHMANN, W, HIGGINS, T, ROZENGURT, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bombesin - pharmacology Cell cycle, cell proliferation Cell Division - drug effects Cell physiology Cells, Cultured Cyclic AMP - metabolism Dinoprostone - physiology Dose-Response Relationship, Drug Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Indomethacin - pharmacology Mice Molecular and cellular biology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-fos RNA, Messenger - genetics RNA, Messenger - metabolism
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