Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms
We have previously reported the identification of a novel mast cell growth factor (MGF) that was shown to be a ligand for c- kit and is encoded by a gene that maps near the steel locus on mouse chromosome 10. We now report the cloning of cDNAs encoding the MGF protein. The MGF protein encoded by thi...
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| Veröffentlicht in: | Cell 1990-10, Vol.63 (1), p.235-243 |
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| container_title | Cell |
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| creator | Anderson, Dirk M. Lyman, Stewart D. Baird, Allison Wignall, Janis M. Eisenman, June Rauch, Charles March, Carl J. Boswell, H.Scott Gimpel, Steven D. Cosman, David Williams, Douglas E. |
| description | We have previously reported the identification of a novel mast cell growth factor (MGF) that was shown to be a ligand for c-
kit and is encoded by a gene that maps near the steel locus on mouse chromosome 10. We now report the cloning of cDNAs encoding the MGF protein. The MGF protein encoded by this cDNA can be expressed in a biologically active form as either a membrane bound protein or as a soluble factor. The soluble protein promotes the proliferation of MGF-responsive cell lines and, in the presence of erythropoietin, stimulates the formation of macrocytic erythroid and multilineage hematopoietic colonies. |
| doi_str_mv | 10.1016/0092-8674(90)90304-W |
| format | Article |
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kit and is encoded by a gene that maps near the steel locus on mouse chromosome 10. We now report the cloning of cDNAs encoding the MGF protein. The MGF protein encoded by this cDNA can be expressed in a biologically active form as either a membrane bound protein or as a soluble factor. The soluble protein promotes the proliferation of MGF-responsive cell lines and, in the presence of erythropoietin, stimulates the formation of macrocytic erythroid and multilineage hematopoietic colonies.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/0092-8674(90)90304-W</identifier><identifier>PMID: 1698558</identifier><identifier>CODEN: CELLB5</identifier><language>eng</language><publisher>Cambridge, MA: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Analytical, structural and metabolic biochemistry ; Animals ; Base Sequence ; Biological and medical sciences ; c-kit ; Cell Division - drug effects ; Cell Line ; Cell Membrane - metabolism ; Cells, Cultured ; Cloning, Molecular ; DNA - genetics ; DNA - isolation & purification ; DNA Replication ; Erythropoietin - pharmacology ; Fundamental and applied biological sciences. Psychology ; Gene Library ; genes ; Hematopoietic Cell Growth Factors - genetics ; Hematopoietic Cell Growth Factors - metabolism ; Hematopoietic Stem Cells - cytology ; Hematopoietic Stem Cells - drug effects ; Kinetics ; Molecular Sequence Data ; Oligonucleotide Probes ; Protein Conformation ; Protein hormones. Growth factors. Cytokines ; Proteins ; Recombinant Proteins - pharmacology ; Restriction Mapping ; RNA, Messenger - genetics ; Stem Cell Factor ; Transfection</subject><ispartof>Cell, 1990-10, Vol.63 (1), p.235-243</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-7bc5286e5fe4670530db3f99fec25a352229dc80a0f2f53265e7e5f01d5ab9603</citedby><cites>FETCH-LOGICAL-c469t-7bc5286e5fe4670530db3f99fec25a352229dc80a0f2f53265e7e5f01d5ab9603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0092-8674(90)90304-W$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19450428$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1698558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anderson, Dirk M.</creatorcontrib><creatorcontrib>Lyman, Stewart D.</creatorcontrib><creatorcontrib>Baird, Allison</creatorcontrib><creatorcontrib>Wignall, Janis M.</creatorcontrib><creatorcontrib>Eisenman, June</creatorcontrib><creatorcontrib>Rauch, Charles</creatorcontrib><creatorcontrib>March, Carl J.</creatorcontrib><creatorcontrib>Boswell, H.Scott</creatorcontrib><creatorcontrib>Gimpel, Steven D.</creatorcontrib><creatorcontrib>Cosman, David</creatorcontrib><creatorcontrib>Williams, Douglas E.</creatorcontrib><title>Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms</title><title>Cell</title><addtitle>Cell</addtitle><description>We have previously reported the identification of a novel mast cell growth factor (MGF) that was shown to be a ligand for c-
kit and is encoded by a gene that maps near the steel locus on mouse chromosome 10. We now report the cloning of cDNAs encoding the MGF protein. The MGF protein encoded by this cDNA can be expressed in a biologically active form as either a membrane bound protein or as a soluble factor. The soluble protein promotes the proliferation of MGF-responsive cell lines and, in the presence of erythropoietin, stimulates the formation of macrocytic erythroid and multilineage hematopoietic colonies.</description><subject>Amino Acid Sequence</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>c-kit</subject><subject>Cell Division - drug effects</subject><subject>Cell Line</subject><subject>Cell Membrane - metabolism</subject><subject>Cells, Cultured</subject><subject>Cloning, Molecular</subject><subject>DNA - genetics</subject><subject>DNA - isolation & purification</subject><subject>DNA Replication</subject><subject>Erythropoietin - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Library</subject><subject>genes</subject><subject>Hematopoietic Cell Growth Factors - genetics</subject><subject>Hematopoietic Cell Growth Factors - metabolism</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Hematopoietic Stem Cells - drug effects</subject><subject>Kinetics</subject><subject>Molecular Sequence Data</subject><subject>Oligonucleotide Probes</subject><subject>Protein Conformation</subject><subject>Protein hormones. Growth factors. Cytokines</subject><subject>Proteins</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Restriction Mapping</subject><subject>RNA, Messenger - genetics</subject><subject>Stem Cell Factor</subject><subject>Transfection</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2L1TAUhoMo43X0HyhkoyhYPUmTttkIMvgFI26UWYY0PZkbSZtrko747029F2eni5CP9zmHk_cl5DGDVwxY9xpA8WboevFcwQsFLYjm6g7ZMVB9I1jP75LdX-Q-eZDzdwAYpJRn5Ix1qp6GHVk_x4B2DSZRG-Lil2saHZ1NLtRiCPQ6xZ9lT52xJaaX1NA9zqbEQ_RY_ELL3hTqM62yv0FaX8ZY8RnnMZkF621dJmrqyjGsY0DqYprzQ3LPmZDx0Wk_J9_ev_t68bG5_PLh08Xby8aKTpWmH63kQ4fSoeh6kC1MY-uUcmi5NK3knKvJDmDAcSdb3knsKwxskmZUHbTn5Nmx7yHFHyvmomeft3_V2eKa9QDAGef_B5kcho4JUUFxBG2KOSd0-pD8bNIvzUBvsejNc715rhXoP7Hoq1r25NR_HWecbouOOVT96Uk32ZrgqnnW51tMCQmCb9ybI4fVtRuPSWfrcbE4-YS26Cn6fw_yG9M3qec</recordid><startdate>19901005</startdate><enddate>19901005</enddate><creator>Anderson, Dirk M.</creator><creator>Lyman, Stewart D.</creator><creator>Baird, Allison</creator><creator>Wignall, Janis M.</creator><creator>Eisenman, June</creator><creator>Rauch, Charles</creator><creator>March, Carl J.</creator><creator>Boswell, H.Scott</creator><creator>Gimpel, Steven D.</creator><creator>Cosman, David</creator><creator>Williams, Douglas E.</creator><general>Elsevier Inc</general><general>Cell Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M81</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19901005</creationdate><title>Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms</title><author>Anderson, Dirk M. ; Lyman, Stewart D. ; Baird, Allison ; Wignall, Janis M. ; Eisenman, June ; Rauch, Charles ; March, Carl J. ; Boswell, H.Scott ; Gimpel, Steven D. ; Cosman, David ; Williams, Douglas E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-7bc5286e5fe4670530db3f99fec25a352229dc80a0f2f53265e7e5f01d5ab9603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Amino Acid Sequence</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>c-kit</topic><topic>Cell Division - drug effects</topic><topic>Cell Line</topic><topic>Cell Membrane - metabolism</topic><topic>Cells, Cultured</topic><topic>Cloning, Molecular</topic><topic>DNA - genetics</topic><topic>DNA - isolation & purification</topic><topic>DNA Replication</topic><topic>Erythropoietin - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Library</topic><topic>genes</topic><topic>Hematopoietic Cell Growth Factors - genetics</topic><topic>Hematopoietic Cell Growth Factors - metabolism</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Hematopoietic Stem Cells - drug effects</topic><topic>Kinetics</topic><topic>Molecular Sequence Data</topic><topic>Oligonucleotide Probes</topic><topic>Protein Conformation</topic><topic>Protein hormones. Growth factors. Cytokines</topic><topic>Proteins</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Restriction Mapping</topic><topic>RNA, Messenger - genetics</topic><topic>Stem Cell Factor</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anderson, Dirk M.</creatorcontrib><creatorcontrib>Lyman, Stewart D.</creatorcontrib><creatorcontrib>Baird, Allison</creatorcontrib><creatorcontrib>Wignall, Janis M.</creatorcontrib><creatorcontrib>Eisenman, June</creatorcontrib><creatorcontrib>Rauch, Charles</creatorcontrib><creatorcontrib>March, Carl J.</creatorcontrib><creatorcontrib>Boswell, H.Scott</creatorcontrib><creatorcontrib>Gimpel, Steven D.</creatorcontrib><creatorcontrib>Cosman, David</creatorcontrib><creatorcontrib>Williams, Douglas E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biochemistry Abstracts 3</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anderson, Dirk M.</au><au>Lyman, Stewart D.</au><au>Baird, Allison</au><au>Wignall, Janis M.</au><au>Eisenman, June</au><au>Rauch, Charles</au><au>March, Carl J.</au><au>Boswell, H.Scott</au><au>Gimpel, Steven D.</au><au>Cosman, David</au><au>Williams, Douglas E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>1990-10-05</date><risdate>1990</risdate><volume>63</volume><issue>1</issue><spage>235</spage><epage>243</epage><pages>235-243</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><coden>CELLB5</coden><abstract>We have previously reported the identification of a novel mast cell growth factor (MGF) that was shown to be a ligand for c-
kit and is encoded by a gene that maps near the steel locus on mouse chromosome 10. We now report the cloning of cDNAs encoding the MGF protein. The MGF protein encoded by this cDNA can be expressed in a biologically active form as either a membrane bound protein or as a soluble factor. The soluble protein promotes the proliferation of MGF-responsive cell lines and, in the presence of erythropoietin, stimulates the formation of macrocytic erythroid and multilineage hematopoietic colonies.</abstract><cop>Cambridge, MA</cop><pub>Elsevier Inc</pub><pmid>1698558</pmid><doi>10.1016/0092-8674(90)90304-W</doi><tpages>9</tpages></addata></record> |
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| subjects | Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Base Sequence Biological and medical sciences c-kit Cell Division - drug effects Cell Line Cell Membrane - metabolism Cells, Cultured Cloning, Molecular DNA - genetics DNA - isolation & purification DNA Replication Erythropoietin - pharmacology Fundamental and applied biological sciences. Psychology Gene Library genes Hematopoietic Cell Growth Factors - genetics Hematopoietic Cell Growth Factors - metabolism Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Kinetics Molecular Sequence Data Oligonucleotide Probes Protein Conformation Protein hormones. Growth factors. Cytokines Proteins Recombinant Proteins - pharmacology Restriction Mapping RNA, Messenger - genetics Stem Cell Factor Transfection |
| title | Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms |
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