Flow and volume dependence of respiratory system mechanics during constant flow ventilation in normal subjects and in adult respiratory distress syndrome
Seven control subjects and seven patients with adult respiratory distress syndrome (ARDS) were artificially ventilated and flow, volume, and tracheal pressure were monitored. Respiratory system resistance (Rrs, max) was partitioned into its homogeneous (Rrs. min) and uneven (Rrs,u) components. Respi...
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| Veröffentlicht in: | Critical care medicine 1990-10, Vol.18 (10), p.1080-1086 |
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| creator | AULER, JOSE O. C SALDIVA, PAULO H. N MARTINS, MILTON A CARVALHO, CARLOS R. R NEGRI, ELNARA M HOELZ, CHRISTIANE ZIN, WALTER A |
| description | Seven control subjects and seven patients with adult respiratory distress syndrome (ARDS) were artificially ventilated and flow, volume, and tracheal pressure were monitored. Respiratory system resistance (Rrs, max) was partitioned into its homogeneous (Rrs. min) and uneven (Rrs,u) components. Respiratory system elastance (Ers) was also measured. In both groups Ers did not vary with different inspiratory flows and volumes, but was significantly higher in ARDS. With increasing volume (isoflow maneuvers), Rrs.max and Rrs,u increased but Rrs,min remained unaltered in ARDS. In control patients, however, resistances did not vary but Rrs, max and Rrs, u were smaller and Rrs,min equaled their corresponding values in ARDS. Hence, stress relaxation seems to be increased in ARDS. During isovolume maneuvers Rrs.max and Rrs.min decreased with increasing flows (both groups), although they were significantly higher in ARDS. Rrs.min, was not modified by different flows and was similar in both groups. Thus, pendelluft is also increased in ARDS. In conclusion, the mechanical profile of ARDS is characterized by increased Ers and Rrs, max the latter being secondary to augmented mechanical unevenness within the system. |
| doi_str_mv | 10.1097/00003246-199010000-00006 |
| format | Article |
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C ; SALDIVA, PAULO H. N ; MARTINS, MILTON A ; CARVALHO, CARLOS R. R ; NEGRI, ELNARA M ; HOELZ, CHRISTIANE ; ZIN, WALTER A</creator><creatorcontrib>AULER, JOSE O. C ; SALDIVA, PAULO H. N ; MARTINS, MILTON A ; CARVALHO, CARLOS R. R ; NEGRI, ELNARA M ; HOELZ, CHRISTIANE ; ZIN, WALTER A</creatorcontrib><description>Seven control subjects and seven patients with adult respiratory distress syndrome (ARDS) were artificially ventilated and flow, volume, and tracheal pressure were monitored. Respiratory system resistance (Rrs, max) was partitioned into its homogeneous (Rrs. min) and uneven (Rrs,u) components. Respiratory system elastance (Ers) was also measured. In both groups Ers did not vary with different inspiratory flows and volumes, but was significantly higher in ARDS. With increasing volume (isoflow maneuvers), Rrs.max and Rrs,u increased but Rrs,min remained unaltered in ARDS. In control patients, however, resistances did not vary but Rrs, max and Rrs, u were smaller and Rrs,min equaled their corresponding values in ARDS. Hence, stress relaxation seems to be increased in ARDS. During isovolume maneuvers Rrs.max and Rrs.min decreased with increasing flows (both groups), although they were significantly higher in ARDS. Rrs.min, was not modified by different flows and was similar in both groups. Thus, pendelluft is also increased in ARDS. In conclusion, the mechanical profile of ARDS is characterized by increased Ers and Rrs, max the latter being secondary to augmented mechanical unevenness within the system.</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/00003246-199010000-00006</identifier><identifier>PMID: 2209034</identifier><identifier>CODEN: CCMDC7</identifier><language>eng</language><publisher>Hagerstown, MD: Williams & Wilkins</publisher><subject>Adolescent ; Adult ; Aged ; Airway Resistance ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Emergency and intensive respiratory care ; Female ; Humans ; Intensive care medicine ; Lung Compliance ; Lung Volume Measurements ; Male ; Medical sciences ; Middle Aged ; Pulmonary Gas Exchange ; Pulmonary Ventilation ; Respiration, Artificial ; Respiratory Dead Space ; Respiratory Distress Syndrome, Adult - physiopathology ; Respiratory Distress Syndrome, Adult - therapy ; Respiratory Mechanics</subject><ispartof>Critical care medicine, 1990-10, Vol.18 (10), p.1080-1086</ispartof><rights>Williams & Wilkins 1990. 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R</creatorcontrib><creatorcontrib>NEGRI, ELNARA M</creatorcontrib><creatorcontrib>HOELZ, CHRISTIANE</creatorcontrib><creatorcontrib>ZIN, WALTER A</creatorcontrib><title>Flow and volume dependence of respiratory system mechanics during constant flow ventilation in normal subjects and in adult respiratory distress syndrome</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>Seven control subjects and seven patients with adult respiratory distress syndrome (ARDS) were artificially ventilated and flow, volume, and tracheal pressure were monitored. Respiratory system resistance (Rrs, max) was partitioned into its homogeneous (Rrs. min) and uneven (Rrs,u) components. Respiratory system elastance (Ers) was also measured. In both groups Ers did not vary with different inspiratory flows and volumes, but was significantly higher in ARDS. With increasing volume (isoflow maneuvers), Rrs.max and Rrs,u increased but Rrs,min remained unaltered in ARDS. In control patients, however, resistances did not vary but Rrs, max and Rrs, u were smaller and Rrs,min equaled their corresponding values in ARDS. Hence, stress relaxation seems to be increased in ARDS. During isovolume maneuvers Rrs.max and Rrs.min decreased with increasing flows (both groups), although they were significantly higher in ARDS. Rrs.min, was not modified by different flows and was similar in both groups. Thus, pendelluft is also increased in ARDS. In conclusion, the mechanical profile of ARDS is characterized by increased Ers and Rrs, max the latter being secondary to augmented mechanical unevenness within the system.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Airway Resistance</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Emergency and intensive respiratory care</subject><subject>Female</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Lung Compliance</subject><subject>Lung Volume Measurements</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pulmonary Gas Exchange</subject><subject>Pulmonary Ventilation</subject><subject>Respiration, Artificial</subject><subject>Respiratory Dead Space</subject><subject>Respiratory Distress Syndrome, Adult - physiopathology</subject><subject>Respiratory Distress Syndrome, Adult - therapy</subject><subject>Respiratory Mechanics</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UsuOFCEUJUYztqOfYMJGd6WXol4szcRRk0nc6LpCwS2bkYKWS02nP2X-Vnq6HeNCFpDzuOcuDoxxAe8EqP49lCPrpquEUiCOqDpe3RO2Ea0soFbyKdsAKKhko-Rz9oLoFkA0bS8v2EVdF0U2G3Z_7eOe62D5XfTrgtziDoPFYJDHmSeknUs6x3TgdKCMC1_QbHVwhrhdkws_uImBsg6Zz8eoOwzZeZ1dDNwFHmJatOe0TrdoMj1sKrS2q8__pFtHuWAqa4JNccGX7NmsPeGr83vJvl9__Hb1ubr5-unL1Yebysih7SqtByunFkzXC6WNsP2APZi5M40A09hJiKnupJiGXjfQK9MWYugUoAGNwyQv2dtT7i7FXytSHhdHBr3XAeNK4wBQg-ihGIeT0aRIlHAed8ktOh1GAeOxlfFPK-NjKw9UV0Zfn3es04L2cfBcQ9HfnHVNRvs56WAc_c1XspZDL4qvOfn20WdM9NOve0zjFrXP2_F_n0L-BnrEqGA</recordid><startdate>199010</startdate><enddate>199010</enddate><creator>AULER, JOSE O. C</creator><creator>SALDIVA, PAULO H. N</creator><creator>MARTINS, MILTON A</creator><creator>CARVALHO, CARLOS R. R</creator><creator>NEGRI, ELNARA M</creator><creator>HOELZ, CHRISTIANE</creator><creator>ZIN, WALTER A</creator><general>Williams & Wilkins</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199010</creationdate><title>Flow and volume dependence of respiratory system mechanics during constant flow ventilation in normal subjects and in adult respiratory distress syndrome</title><author>AULER, JOSE O. C ; SALDIVA, PAULO H. N ; MARTINS, MILTON A ; CARVALHO, CARLOS R. R ; NEGRI, ELNARA M ; HOELZ, CHRISTIANE ; ZIN, WALTER A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3856-aa8d3b50c6719ac1d78e70cf6c410c4db11b2631b87a4079c511b8690ec0ae8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Airway Resistance</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Emergency and intensive respiratory care</topic><topic>Female</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Lung Compliance</topic><topic>Lung Volume Measurements</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pulmonary Gas Exchange</topic><topic>Pulmonary Ventilation</topic><topic>Respiration, Artificial</topic><topic>Respiratory Dead Space</topic><topic>Respiratory Distress Syndrome, Adult - physiopathology</topic><topic>Respiratory Distress Syndrome, Adult - therapy</topic><topic>Respiratory Mechanics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AULER, JOSE O. C</creatorcontrib><creatorcontrib>SALDIVA, PAULO H. N</creatorcontrib><creatorcontrib>MARTINS, MILTON A</creatorcontrib><creatorcontrib>CARVALHO, CARLOS R. R</creatorcontrib><creatorcontrib>NEGRI, ELNARA M</creatorcontrib><creatorcontrib>HOELZ, CHRISTIANE</creatorcontrib><creatorcontrib>ZIN, WALTER A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AULER, JOSE O. C</au><au>SALDIVA, PAULO H. N</au><au>MARTINS, MILTON A</au><au>CARVALHO, CARLOS R. R</au><au>NEGRI, ELNARA M</au><au>HOELZ, CHRISTIANE</au><au>ZIN, WALTER A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Flow and volume dependence of respiratory system mechanics during constant flow ventilation in normal subjects and in adult respiratory distress syndrome</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>1990-10</date><risdate>1990</risdate><volume>18</volume><issue>10</issue><spage>1080</spage><epage>1086</epage><pages>1080-1086</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><coden>CCMDC7</coden><abstract>Seven control subjects and seven patients with adult respiratory distress syndrome (ARDS) were artificially ventilated and flow, volume, and tracheal pressure were monitored. Respiratory system resistance (Rrs, max) was partitioned into its homogeneous (Rrs. min) and uneven (Rrs,u) components. Respiratory system elastance (Ers) was also measured. In both groups Ers did not vary with different inspiratory flows and volumes, but was significantly higher in ARDS. With increasing volume (isoflow maneuvers), Rrs.max and Rrs,u increased but Rrs,min remained unaltered in ARDS. In control patients, however, resistances did not vary but Rrs, max and Rrs, u were smaller and Rrs,min equaled their corresponding values in ARDS. Hence, stress relaxation seems to be increased in ARDS. During isovolume maneuvers Rrs.max and Rrs.min decreased with increasing flows (both groups), although they were significantly higher in ARDS. Rrs.min, was not modified by different flows and was similar in both groups. Thus, pendelluft is also increased in ARDS. In conclusion, the mechanical profile of ARDS is characterized by increased Ers and Rrs, max the latter being secondary to augmented mechanical unevenness within the system.</abstract><cop>Hagerstown, MD</cop><pub>Williams & Wilkins</pub><pmid>2209034</pmid><doi>10.1097/00003246-199010000-00006</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Airway Resistance Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Emergency and intensive respiratory care Female Humans Intensive care medicine Lung Compliance Lung Volume Measurements Male Medical sciences Middle Aged Pulmonary Gas Exchange Pulmonary Ventilation Respiration, Artificial Respiratory Dead Space Respiratory Distress Syndrome, Adult - physiopathology Respiratory Distress Syndrome, Adult - therapy Respiratory Mechanics |
| title | Flow and volume dependence of respiratory system mechanics during constant flow ventilation in normal subjects and in adult respiratory distress syndrome |
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