Nitric oxide and human thermal injury short term outcome
Nitric oxide (NO) is an important mediator in numerous physiological and pathophysiological events. After thermal injury an increase in plasma and urinary levels has been observed. The real importance of this fact is unknown. The stable NO derivatives ( NO 2 − NO 3 − ) plasma concentrations were det...
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| Veröffentlicht in: | Burns 1998-05, Vol.24 (3), p.207-212 |
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| creator | Caneira da Silva, Manuel do Rosário Filipe, Helder Mota Amaro Pinto, Rui Manuel Salaverría Timóteo de Carvalho, Maria Francisca Monteiro Godinho de Matos, Manuel Maria Ferreira, Acácio Cordeiro Gião Toscano Rico, JoséManuel |
| description | Nitric oxide (NO) is an important mediator in numerous physiological and pathophysiological events. After thermal injury an increase in plasma and urinary levels has been observed. The real importance of this fact is unknown. The stable NO derivatives (
NO
2
−
NO
3
−
) plasma concentrations were determined in 27 burned patients admitted to the Burn Unit at Santa Maria Hospital Hospital in Lisbon at first, third, fifth, seventh, ninth and 15th days and the values were compared with healthy controls (
n = 9). A significant increase (
P < 0.05) in burn patient determinations upon admission was found. The patients with inhalation injury revealed greater values compared to the other patients with statistical significance at 5th day (
P < 0.05). The patients who died showed a NO increase (0.397 ± 0.138 vs. 0.267 ± 0.017,
P > 0.1, day 1) with significance at day 5 (0.615 ± 0.223 vs. 0.154 ± 0.048,
P < 0.05). The determinations in patients with sepsis were higher than in the other patients (
P < 0.01) at day 3. No relation with total burned surface area (TBSA) was found. For the first time, considering burned patients, a significant increase of NO was found in patients who died, in patients with inhalation injury and in patients in sepsis. The possible role of NO in burn injury is discussed. The authors suggest the possible role of NO determination as an indicator of sepsis. The role of NO synthesis inhibitors is discussed. Further studies are needed to clarify these questions. |
| doi_str_mv | 10.1016/S0305-4179(98)00014-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80020062</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S030541799800014X</els_id><sourcerecordid>80020062</sourcerecordid><originalsourceid>FETCH-LOGICAL-c455t-56a05b62d901a672321f927b5ba05b2345283be74c0049db49f36534a65e59cb3</originalsourceid><addsrcrecordid>eNqFkF1LwzAUhoMoc05_wqAXInpRPUmTtLkSGX7B0AsVdhfSNGUZbTOTVty_t9vKbr068J7nfPAgNMVwiwHzuw9IgMUUp-JaZDcAgGm8OEJjnKUixhTEMRofkFN0FsKqh4BlMEIjwdMUCBmj7M223urI_drCRKopomVXqyZql8bXqopss-r8JgpL59uo7bPIda12tTlHJ6WqgrkY6gR9PT1-zl7i-fvz6-xhHmvKWBszroDlnBQCsOIpSQguBUlzlm9zklBGsiQ3KdUAVBQ5FWXCWUIVZ4YJnScTdLXfu_buuzOhlbUN2lSVaozrgswACAAnPcj2oPYuBG9Kufa2Vn4jMcitMbkzJrc6pMjkzphc9HPT4UCX16Y4TA2K-v7l0FdBq6r0qtE2HDBCBGM47bH7PWZ6GT_WeBm0NY02hfVGt7Jw9p9H_gCXmIYE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80020062</pqid></control><display><type>article</type><title>Nitric oxide and human thermal injury short term outcome</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Caneira da Silva, Manuel do Rosário ; Filipe, Helder Mota ; Amaro Pinto, Rui Manuel ; Salaverría Timóteo de Carvalho, Maria Francisca ; Monteiro Godinho de Matos, Manuel Maria ; Ferreira, Acácio Cordeiro ; Gião Toscano Rico, JoséManuel</creator><creatorcontrib>Caneira da Silva, Manuel do Rosário ; Filipe, Helder Mota ; Amaro Pinto, Rui Manuel ; Salaverría Timóteo de Carvalho, Maria Francisca ; Monteiro Godinho de Matos, Manuel Maria ; Ferreira, Acácio Cordeiro ; Gião Toscano Rico, JoséManuel</creatorcontrib><description>Nitric oxide (NO) is an important mediator in numerous physiological and pathophysiological events. After thermal injury an increase in plasma and urinary levels has been observed. The real importance of this fact is unknown. The stable NO derivatives (
NO
2
−
NO
3
−
) plasma concentrations were determined in 27 burned patients admitted to the Burn Unit at Santa Maria Hospital Hospital in Lisbon at first, third, fifth, seventh, ninth and 15th days and the values were compared with healthy controls (
n = 9). A significant increase (
P < 0.05) in burn patient determinations upon admission was found. The patients with inhalation injury revealed greater values compared to the other patients with statistical significance at 5th day (
P < 0.05). The patients who died showed a NO increase (0.397 ± 0.138 vs. 0.267 ± 0.017,
P > 0.1, day 1) with significance at day 5 (0.615 ± 0.223 vs. 0.154 ± 0.048,
P < 0.05). The determinations in patients with sepsis were higher than in the other patients (
P < 0.01) at day 3. No relation with total burned surface area (TBSA) was found. For the first time, considering burned patients, a significant increase of NO was found in patients who died, in patients with inhalation injury and in patients in sepsis. The possible role of NO in burn injury is discussed. The authors suggest the possible role of NO determination as an indicator of sepsis. The role of NO synthesis inhibitors is discussed. Further studies are needed to clarify these questions.</description><identifier>ISSN: 0305-4179</identifier><identifier>EISSN: 1879-1409</identifier><identifier>DOI: 10.1016/S0305-4179(98)00014-X</identifier><identifier>PMID: 9677022</identifier><identifier>CODEN: BURND8</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers - blood ; Burns ; Burns - blood ; Burns - mortality ; Follow-Up Studies ; Humans ; Medical sciences ; Middle Aged ; Nitrates - blood ; Nitric oxide ; Nitric Oxide - blood ; Nitrites - blood ; Outcome ; Prognosis ; Thermal injury ; Trauma Severity Indices ; Traumas. Diseases due to physical agents</subject><ispartof>Burns, 1998-05, Vol.24 (3), p.207-212</ispartof><rights>1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-56a05b62d901a672321f927b5ba05b2345283be74c0049db49f36534a65e59cb3</citedby><cites>FETCH-LOGICAL-c455t-56a05b62d901a672321f927b5ba05b2345283be74c0049db49f36534a65e59cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0305-4179(98)00014-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27925,27926,45996</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2295517$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9677022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caneira da Silva, Manuel do Rosário</creatorcontrib><creatorcontrib>Filipe, Helder Mota</creatorcontrib><creatorcontrib>Amaro Pinto, Rui Manuel</creatorcontrib><creatorcontrib>Salaverría Timóteo de Carvalho, Maria Francisca</creatorcontrib><creatorcontrib>Monteiro Godinho de Matos, Manuel Maria</creatorcontrib><creatorcontrib>Ferreira, Acácio Cordeiro</creatorcontrib><creatorcontrib>Gião Toscano Rico, JoséManuel</creatorcontrib><title>Nitric oxide and human thermal injury short term outcome</title><title>Burns</title><addtitle>Burns</addtitle><description>Nitric oxide (NO) is an important mediator in numerous physiological and pathophysiological events. After thermal injury an increase in plasma and urinary levels has been observed. The real importance of this fact is unknown. The stable NO derivatives (
NO
2
−
NO
3
−
) plasma concentrations were determined in 27 burned patients admitted to the Burn Unit at Santa Maria Hospital Hospital in Lisbon at first, third, fifth, seventh, ninth and 15th days and the values were compared with healthy controls (
n = 9). A significant increase (
P < 0.05) in burn patient determinations upon admission was found. The patients with inhalation injury revealed greater values compared to the other patients with statistical significance at 5th day (
P < 0.05). The patients who died showed a NO increase (0.397 ± 0.138 vs. 0.267 ± 0.017,
P > 0.1, day 1) with significance at day 5 (0.615 ± 0.223 vs. 0.154 ± 0.048,
P < 0.05). The determinations in patients with sepsis were higher than in the other patients (
P < 0.01) at day 3. No relation with total burned surface area (TBSA) was found. For the first time, considering burned patients, a significant increase of NO was found in patients who died, in patients with inhalation injury and in patients in sepsis. The possible role of NO in burn injury is discussed. The authors suggest the possible role of NO determination as an indicator of sepsis. The role of NO synthesis inhibitors is discussed. Further studies are needed to clarify these questions.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Burns</subject><subject>Burns - blood</subject><subject>Burns - mortality</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nitrates - blood</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - blood</subject><subject>Nitrites - blood</subject><subject>Outcome</subject><subject>Prognosis</subject><subject>Thermal injury</subject><subject>Trauma Severity Indices</subject><subject>Traumas. Diseases due to physical agents</subject><issn>0305-4179</issn><issn>1879-1409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LwzAUhoMoc05_wqAXInpRPUmTtLkSGX7B0AsVdhfSNGUZbTOTVty_t9vKbr068J7nfPAgNMVwiwHzuw9IgMUUp-JaZDcAgGm8OEJjnKUixhTEMRofkFN0FsKqh4BlMEIjwdMUCBmj7M223urI_drCRKopomVXqyZql8bXqopss-r8JgpL59uo7bPIda12tTlHJ6WqgrkY6gR9PT1-zl7i-fvz6-xhHmvKWBszroDlnBQCsOIpSQguBUlzlm9zklBGsiQ3KdUAVBQ5FWXCWUIVZ4YJnScTdLXfu_buuzOhlbUN2lSVaozrgswACAAnPcj2oPYuBG9Kufa2Vn4jMcitMbkzJrc6pMjkzphc9HPT4UCX16Y4TA2K-v7l0FdBq6r0qtE2HDBCBGM47bH7PWZ6GT_WeBm0NY02hfVGt7Jw9p9H_gCXmIYE</recordid><startdate>19980501</startdate><enddate>19980501</enddate><creator>Caneira da Silva, Manuel do Rosário</creator><creator>Filipe, Helder Mota</creator><creator>Amaro Pinto, Rui Manuel</creator><creator>Salaverría Timóteo de Carvalho, Maria Francisca</creator><creator>Monteiro Godinho de Matos, Manuel Maria</creator><creator>Ferreira, Acácio Cordeiro</creator><creator>Gião Toscano Rico, JoséManuel</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980501</creationdate><title>Nitric oxide and human thermal injury short term outcome</title><author>Caneira da Silva, Manuel do Rosário ; Filipe, Helder Mota ; Amaro Pinto, Rui Manuel ; Salaverría Timóteo de Carvalho, Maria Francisca ; Monteiro Godinho de Matos, Manuel Maria ; Ferreira, Acácio Cordeiro ; Gião Toscano Rico, JoséManuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-56a05b62d901a672321f927b5ba05b2345283be74c0049db49f36534a65e59cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Burns</topic><topic>Burns - blood</topic><topic>Burns - mortality</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nitrates - blood</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - blood</topic><topic>Nitrites - blood</topic><topic>Outcome</topic><topic>Prognosis</topic><topic>Thermal injury</topic><topic>Trauma Severity Indices</topic><topic>Traumas. Diseases due to physical agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caneira da Silva, Manuel do Rosário</creatorcontrib><creatorcontrib>Filipe, Helder Mota</creatorcontrib><creatorcontrib>Amaro Pinto, Rui Manuel</creatorcontrib><creatorcontrib>Salaverría Timóteo de Carvalho, Maria Francisca</creatorcontrib><creatorcontrib>Monteiro Godinho de Matos, Manuel Maria</creatorcontrib><creatorcontrib>Ferreira, Acácio Cordeiro</creatorcontrib><creatorcontrib>Gião Toscano Rico, JoséManuel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Burns</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caneira da Silva, Manuel do Rosário</au><au>Filipe, Helder Mota</au><au>Amaro Pinto, Rui Manuel</au><au>Salaverría Timóteo de Carvalho, Maria Francisca</au><au>Monteiro Godinho de Matos, Manuel Maria</au><au>Ferreira, Acácio Cordeiro</au><au>Gião Toscano Rico, JoséManuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nitric oxide and human thermal injury short term outcome</atitle><jtitle>Burns</jtitle><addtitle>Burns</addtitle><date>1998-05-01</date><risdate>1998</risdate><volume>24</volume><issue>3</issue><spage>207</spage><epage>212</epage><pages>207-212</pages><issn>0305-4179</issn><eissn>1879-1409</eissn><coden>BURND8</coden><abstract>Nitric oxide (NO) is an important mediator in numerous physiological and pathophysiological events. After thermal injury an increase in plasma and urinary levels has been observed. The real importance of this fact is unknown. The stable NO derivatives (
NO
2
−
NO
3
−
) plasma concentrations were determined in 27 burned patients admitted to the Burn Unit at Santa Maria Hospital Hospital in Lisbon at first, third, fifth, seventh, ninth and 15th days and the values were compared with healthy controls (
n = 9). A significant increase (
P < 0.05) in burn patient determinations upon admission was found. The patients with inhalation injury revealed greater values compared to the other patients with statistical significance at 5th day (
P < 0.05). The patients who died showed a NO increase (0.397 ± 0.138 vs. 0.267 ± 0.017,
P > 0.1, day 1) with significance at day 5 (0.615 ± 0.223 vs. 0.154 ± 0.048,
P < 0.05). The determinations in patients with sepsis were higher than in the other patients (
P < 0.01) at day 3. No relation with total burned surface area (TBSA) was found. For the first time, considering burned patients, a significant increase of NO was found in patients who died, in patients with inhalation injury and in patients in sepsis. The possible role of NO in burn injury is discussed. The authors suggest the possible role of NO determination as an indicator of sepsis. The role of NO synthesis inhibitors is discussed. Further studies are needed to clarify these questions.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9677022</pmid><doi>10.1016/S0305-4179(98)00014-X</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers - blood Burns Burns - blood Burns - mortality Follow-Up Studies Humans Medical sciences Middle Aged Nitrates - blood Nitric oxide Nitric Oxide - blood Nitrites - blood Outcome Prognosis Thermal injury Trauma Severity Indices Traumas. Diseases due to physical agents |
| title | Nitric oxide and human thermal injury short term outcome |
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