The influence of plasma butyrylcholinesterase concentration on the in vitro hydrolysis of cocaine in human plasma

In humans, the plasma enzyme butyrylcholinesterase, BChE (EC 3.1.1.8), mediates the in vivo plasma hydrolysis of cocaine to the pharmacologically inactive metabolite ecgonine methyl ester, EME. This enzyme has been purified from human plasma to investigate the potential as a treatment for cocaine in...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 1998-07, Vol.19 (5), p.309-314
Hauptverfasser:	Browne, Susan P., Slaughter, Elizabeth A., Couch, Richard A., Rudnic, Edward M., McLean, Angus M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences butyrylcholinesterase Butyrylcholinesterase - blood cocaine Cocaine - blood Drug addictions ecgonine methyl ester Half-Life Humans Hydrolysis Medical sciences plasma hydrolysis Toxicology
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