Antibiotic therapy in preterm premature rupture of membranes: A randomized, prospective, double-blind trial
The use of antibiotics in the management of preterm, premature rupture of membranes remains controversial. By use of a prospective randomized double-blind design we investigated the maternal-fetal benefits associated with antibiotic therapy in 85 women with premature rupture of membranes at 34 weeks...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1990-09, Vol.163 (3), p.743-747 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Johnston, Matthew M. Sanchez-Ramos, Luis Vaughn, Arthur J. Todd, Mark W. Benrubi, Guy I. |
| description | The use of antibiotics in the management of preterm, premature rupture of membranes remains controversial. By use of a prospective randomized double-blind design we investigated the maternal-fetal benefits associated with antibiotic therapy in 85 women with premature rupture of membranes at 34 weeks' estimated gestational age. In the treatment group 40 patients received intravenous mezlocillin for 48 hours followed by oral ampicillin until delivery. In the control group 45 patients received intravenous and oral placebo. Patients who received antibiotics had chorioamnionitis and endometritis less frequently than the control group (p < 0.01 and p < 0.05). Pathologic examination of the placentas showed a lower incidence of chorioamnionitis in the treatment group (p < 0.05). The period from premature rupture of membranes to delivery (latency) was prolonged with antibiotics (p < 0.05) and resulted in significant weight gain in the infants in the antibiotic group (p < 0.0001). These infants also had higher 1- and 5-minute Apgar scores. Clinically suspected sepsis, respiratory distress syndrome, intraventricular hemorrhage, perinatal death rate, and prolonged hospitalization (>30 days) were also increased in the control group. |
| doi_str_mv | 10.1016/0002-9378(90)91060-P |
| format | Article |
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By use of a prospective randomized double-blind design we investigated the maternal-fetal benefits associated with antibiotic therapy in 85 women with premature rupture of membranes at 34 weeks' estimated gestational age. In the treatment group 40 patients received intravenous mezlocillin for 48 hours followed by oral ampicillin until delivery. In the control group 45 patients received intravenous and oral placebo. Patients who received antibiotics had chorioamnionitis and endometritis less frequently than the control group (p < 0.01 and p < 0.05). Pathologic examination of the placentas showed a lower incidence of chorioamnionitis in the treatment group (p < 0.05). The period from premature rupture of membranes to delivery (latency) was prolonged with antibiotics (p < 0.05) and resulted in significant weight gain in the infants in the antibiotic group (p < 0.0001). These infants also had higher 1- and 5-minute Apgar scores. Clinically suspected sepsis, respiratory distress syndrome, intraventricular hemorrhage, perinatal death rate, and prolonged hospitalization (>30 days) were also increased in the control group.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(90)91060-P</identifier><identifier>PMID: 2206065</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Administration, Oral ; Adult ; Ampicillin - administration & dosage ; Ampicillin - therapeutic use ; Antiobiotics ; Chorioamnionitis - prevention & control ; Double-Blind Method ; Drug Therapy, Combination - therapeutic use ; Endometritis - prevention & control ; Female ; Fetal Death - prevention & control ; Fetal Membranes, Premature Rupture - complications ; Fetal Membranes, Premature Rupture - drug therapy ; Humans ; Infusions, Intravenous ; Mezlocillin - administration & dosage ; Mezlocillin - therapeutic use ; Pregnancy ; premature rupture of membranes ; preterm ; Prospective Studies ; Randomized Controlled Trials as Topic</subject><ispartof>American journal of obstetrics and gynecology, 1990-09, Vol.163 (3), p.743-747</ispartof><rights>1990 Mosby</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-8ffe134e9c8207ca855a47c58738cf5abe94aa1d0739137e1667f57bba376a023</citedby><cites>FETCH-LOGICAL-c357t-8ffe134e9c8207ca855a47c58738cf5abe94aa1d0739137e1667f57bba376a023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/000293789091060P$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2206065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnston, Matthew M.</creatorcontrib><creatorcontrib>Sanchez-Ramos, Luis</creatorcontrib><creatorcontrib>Vaughn, Arthur J.</creatorcontrib><creatorcontrib>Todd, Mark W.</creatorcontrib><creatorcontrib>Benrubi, Guy I.</creatorcontrib><title>Antibiotic therapy in preterm premature rupture of membranes: A randomized, prospective, double-blind trial</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>The use of antibiotics in the management of preterm, premature rupture of membranes remains controversial. By use of a prospective randomized double-blind design we investigated the maternal-fetal benefits associated with antibiotic therapy in 85 women with premature rupture of membranes at 34 weeks' estimated gestational age. In the treatment group 40 patients received intravenous mezlocillin for 48 hours followed by oral ampicillin until delivery. In the control group 45 patients received intravenous and oral placebo. Patients who received antibiotics had chorioamnionitis and endometritis less frequently than the control group (p < 0.01 and p < 0.05). Pathologic examination of the placentas showed a lower incidence of chorioamnionitis in the treatment group (p < 0.05). The period from premature rupture of membranes to delivery (latency) was prolonged with antibiotics (p < 0.05) and resulted in significant weight gain in the infants in the antibiotic group (p < 0.0001). These infants also had higher 1- and 5-minute Apgar scores. Clinically suspected sepsis, respiratory distress syndrome, intraventricular hemorrhage, perinatal death rate, and prolonged hospitalization (>30 days) were also increased in the control group.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Ampicillin - administration & dosage</subject><subject>Ampicillin - therapeutic use</subject><subject>Antiobiotics</subject><subject>Chorioamnionitis - prevention & control</subject><subject>Double-Blind Method</subject><subject>Drug Therapy, Combination - therapeutic use</subject><subject>Endometritis - prevention & control</subject><subject>Female</subject><subject>Fetal Death - prevention & control</subject><subject>Fetal Membranes, Premature Rupture - complications</subject><subject>Fetal Membranes, Premature Rupture - drug therapy</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Mezlocillin - administration & dosage</subject><subject>Mezlocillin - therapeutic use</subject><subject>Pregnancy</subject><subject>premature rupture of membranes</subject><subject>preterm</subject><subject>Prospective Studies</subject><subject>Randomized Controlled Trials as Topic</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kElLBDEQhYMoOi7_QCEnUbA16Uxn8SAM4gaCHvQc0ulqjPZmkhbGX2_aGTx6elXUq8rLh9AhJeeUUH5BCMkzxYQ8UeRUUcJJ9ryBZpQokXHJ5Saa_Vl20G4I71Obq3wbbed5svNihj4WXXSl66OzOL6BN8MSuw4PHiL4dtLWxNED9uPwq32NW2hLbzoIl3iBU1H1rfuG6iy5-zCAje4LznDVj2UDWdm4rsLRO9Pso63aNAEO1rqHXm9vXq7vs8enu4frxWNmWSFiJusaKJuDsjInwhpZFGYubCEFk7YuTAlqbgytiGCKMgGUc1EXoiwNE9yQnO2h49XdlOdzhBB164KFpkmZ-zFoSQiVjBfJOF8ZbQoePNR68K41fqkp0RNjPRHTE0CtiP5lrJ_T2tH6_li2UP0traGm-dVqDumTXw68DtZBZ6FyPtHRVe_-f-AHs9eMlg</recordid><startdate>19900901</startdate><enddate>19900901</enddate><creator>Johnston, Matthew M.</creator><creator>Sanchez-Ramos, Luis</creator><creator>Vaughn, Arthur J.</creator><creator>Todd, Mark W.</creator><creator>Benrubi, Guy I.</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900901</creationdate><title>Antibiotic therapy in preterm premature rupture of membranes: A randomized, prospective, double-blind trial</title><author>Johnston, Matthew M. ; Sanchez-Ramos, Luis ; Vaughn, Arthur J. ; Todd, Mark W. ; Benrubi, Guy I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-8ffe134e9c8207ca855a47c58738cf5abe94aa1d0739137e1667f57bba376a023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Ampicillin - administration & dosage</topic><topic>Ampicillin - therapeutic use</topic><topic>Antiobiotics</topic><topic>Chorioamnionitis - prevention & control</topic><topic>Double-Blind Method</topic><topic>Drug Therapy, Combination - therapeutic use</topic><topic>Endometritis - prevention & control</topic><topic>Female</topic><topic>Fetal Death - prevention & control</topic><topic>Fetal Membranes, Premature Rupture - complications</topic><topic>Fetal Membranes, Premature Rupture - drug therapy</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Mezlocillin - administration & dosage</topic><topic>Mezlocillin - therapeutic use</topic><topic>Pregnancy</topic><topic>premature rupture of membranes</topic><topic>preterm</topic><topic>Prospective Studies</topic><topic>Randomized Controlled Trials as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnston, Matthew M.</creatorcontrib><creatorcontrib>Sanchez-Ramos, Luis</creatorcontrib><creatorcontrib>Vaughn, Arthur J.</creatorcontrib><creatorcontrib>Todd, Mark W.</creatorcontrib><creatorcontrib>Benrubi, Guy I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnston, Matthew M.</au><au>Sanchez-Ramos, Luis</au><au>Vaughn, Arthur J.</au><au>Todd, Mark W.</au><au>Benrubi, Guy I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibiotic therapy in preterm premature rupture of membranes: A randomized, prospective, double-blind trial</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1990-09-01</date><risdate>1990</risdate><volume>163</volume><issue>3</issue><spage>743</spage><epage>747</epage><pages>743-747</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><abstract>The use of antibiotics in the management of preterm, premature rupture of membranes remains controversial. By use of a prospective randomized double-blind design we investigated the maternal-fetal benefits associated with antibiotic therapy in 85 women with premature rupture of membranes at 34 weeks' estimated gestational age. In the treatment group 40 patients received intravenous mezlocillin for 48 hours followed by oral ampicillin until delivery. In the control group 45 patients received intravenous and oral placebo. Patients who received antibiotics had chorioamnionitis and endometritis less frequently than the control group (p < 0.01 and p < 0.05). Pathologic examination of the placentas showed a lower incidence of chorioamnionitis in the treatment group (p < 0.05). The period from premature rupture of membranes to delivery (latency) was prolonged with antibiotics (p < 0.05) and resulted in significant weight gain in the infants in the antibiotic group (p < 0.0001). These infants also had higher 1- and 5-minute Apgar scores. Clinically suspected sepsis, respiratory distress syndrome, intraventricular hemorrhage, perinatal death rate, and prolonged hospitalization (>30 days) were also increased in the control group.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>2206065</pmid><doi>10.1016/0002-9378(90)91060-P</doi><tpages>5</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 1990-09, Vol.163 (3), p.743-747 |
| issn | 0002-9378 1097-6868 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Oral Adult Ampicillin - administration & dosage Ampicillin - therapeutic use Antiobiotics Chorioamnionitis - prevention & control Double-Blind Method Drug Therapy, Combination - therapeutic use Endometritis - prevention & control Female Fetal Death - prevention & control Fetal Membranes, Premature Rupture - complications Fetal Membranes, Premature Rupture - drug therapy Humans Infusions, Intravenous Mezlocillin - administration & dosage Mezlocillin - therapeutic use Pregnancy premature rupture of membranes preterm Prospective Studies Randomized Controlled Trials as Topic |
| title | Antibiotic therapy in preterm premature rupture of membranes: A randomized, prospective, double-blind trial |
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