HLA associations with multiple sclerosis in the Canary Islands
The study of small island populations has proved informative with respect to the epidemiology and genetics of many complex traits including multiple sclerosis. The class II major histocompatibility antigen DR15 is associated with multiple sclerosis in all groups except Sardinians, where the primary...
Gespeichert in:
| Veröffentlicht in: | Journal of neuroimmunology 1998-07, Vol.87 (1), p.130-135 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 135 |
|---|---|
| container_issue | 1 |
| container_start_page | 130 |
| container_title | Journal of neuroimmunology |
| container_volume | 87 |
| creator | Coraddu, F Reyes-Yanez, M.P Parra, A Gray, J Smith, S.I Taylor, C.J Compston, D.A.S |
| description | The study of small island populations has proved informative with respect to the epidemiology and genetics of many complex traits including multiple sclerosis. The class II major histocompatibility antigen DR15 is associated with multiple sclerosis in all groups except Sardinians, where the primary association is with DR4. We compared HLA-DR and -DQ allele frequencies in a representative sample of patients with multiple sclerosis from the Canary Islands with appropriate controls. There was a significant association with DR15 (patients 21/53; 40%: controls 11/55; 20%:
X
2=4.09;
p
c=0.04; relative risk [RR]=1.98). DRB1*1501–DRB5*0101 was present in 17/53 (32%) patients in whom sub-types could be identified compared with 6/55 (11%) controls (
X
2=7.21;
p
c= |
| doi_str_mv | 10.1016/S0165-5728(98)00074-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80018335</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165572898000745</els_id><sourcerecordid>80018335</sourcerecordid><originalsourceid>FETCH-LOGICAL-c443t-689a22d194d58b097f0be1bc8b558cdbaf63b3940dfbc554d6158c332e41f2be3</originalsourceid><addsrcrecordid>eNqFkEtLAzEUhYMotVZ_QmFWoovRZJLMJBulFLWFggt1HfK4QyPzqJMZxX9v-qBbNzdwz0lOzofQlOA7gkl-_xYHT3mRiRspbjHGBUv5CRoTUWSpYBk5ReOj5RxdhPCJMeGUyREaybzAgrMxelisZokOobVe975tQvLj-3VSD1XvNxUkwVbQtcGHxDdJv4Zkrhvd_SbLUOnGhUt0VuoqwNXhnKCP56f3-SJdvb4s57NVahmjfZoLqbPMEckcFwbLosQGiLHCcC6sM7rMqaGSYVcayzlzOYl7SjNgpMwM0Am63r-76dqvAUKvah8sVPET0A5BiVhNUMr_NZKcSkGkjEa-N9pYL3RQqk3n61hNEay2gNUOsNrSU1KoHWC1DZgeAgZTgzveOhCN-uNeh4jj20OngvXQWHC-A9sr1_p_Ev4A9NWJ_A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16398199</pqid></control><display><type>article</type><title>HLA associations with multiple sclerosis in the Canary Islands</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Coraddu, F ; Reyes-Yanez, M.P ; Parra, A ; Gray, J ; Smith, S.I ; Taylor, C.J ; Compston, D.A.S</creator><creatorcontrib>Coraddu, F ; Reyes-Yanez, M.P ; Parra, A ; Gray, J ; Smith, S.I ; Taylor, C.J ; Compston, D.A.S</creatorcontrib><description>The study of small island populations has proved informative with respect to the epidemiology and genetics of many complex traits including multiple sclerosis. The class II major histocompatibility antigen DR15 is associated with multiple sclerosis in all groups except Sardinians, where the primary association is with DR4. We compared HLA-DR and -DQ allele frequencies in a representative sample of patients with multiple sclerosis from the Canary Islands with appropriate controls. There was a significant association with DR15 (patients 21/53; 40%: controls 11/55; 20%:
X
2=4.09;
p
c=0.04; relative risk [RR]=1.98). DRB1*1501–DRB5*0101 was present in 17/53 (32%) patients in whom sub-types could be identified compared with 6/55 (11%) controls (
X
2=7.21;
p
c=<0.01; RR=2.94). All DR15 positive controls carried the DQA1*0102, DQB1*0602 haplotype whereas this was only present in 26/30 patients, suggesting that the primary association is with HLA-DR and not -DQ. We also found a significant increase in HLA-DR4 (16/53 [30%] in patients compared with 7/55 [13%] in controls;
p
c=0.05). This study contributes a new point on the immunogenetic map of multiple sclerosis in Europe, confirming the primary DR15 association with multiple sclerosis in a previously unstudied population but again highlighting the importance of DR4 in Mediterranean peoples.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/S0165-5728(98)00074-5</identifier><identifier>PMID: 9670854</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alleles ; Atlantic Islands ; Canary Islands ; Gene Frequency - genetics ; Genetic Variation - genetics ; Genotype ; Haplotypes - genetics ; HLA ; HLA-DQ Antigens - analysis ; HLA-DQ Antigens - genetics ; HLA-DR Antigens - analysis ; HLA-DR Antigens - genetics ; Humans ; Multiple sclerosis ; Multiple Sclerosis - immunology ; Phenotype ; Reference Values</subject><ispartof>Journal of neuroimmunology, 1998-07, Vol.87 (1), p.130-135</ispartof><rights>1998 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-689a22d194d58b097f0be1bc8b558cdbaf63b3940dfbc554d6158c332e41f2be3</citedby><cites>FETCH-LOGICAL-c443t-689a22d194d58b097f0be1bc8b558cdbaf63b3940dfbc554d6158c332e41f2be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0165-5728(98)00074-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9670854$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coraddu, F</creatorcontrib><creatorcontrib>Reyes-Yanez, M.P</creatorcontrib><creatorcontrib>Parra, A</creatorcontrib><creatorcontrib>Gray, J</creatorcontrib><creatorcontrib>Smith, S.I</creatorcontrib><creatorcontrib>Taylor, C.J</creatorcontrib><creatorcontrib>Compston, D.A.S</creatorcontrib><title>HLA associations with multiple sclerosis in the Canary Islands</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>The study of small island populations has proved informative with respect to the epidemiology and genetics of many complex traits including multiple sclerosis. The class II major histocompatibility antigen DR15 is associated with multiple sclerosis in all groups except Sardinians, where the primary association is with DR4. We compared HLA-DR and -DQ allele frequencies in a representative sample of patients with multiple sclerosis from the Canary Islands with appropriate controls. There was a significant association with DR15 (patients 21/53; 40%: controls 11/55; 20%:
X
2=4.09;
p
c=0.04; relative risk [RR]=1.98). DRB1*1501–DRB5*0101 was present in 17/53 (32%) patients in whom sub-types could be identified compared with 6/55 (11%) controls (
X
2=7.21;
p
c=<0.01; RR=2.94). All DR15 positive controls carried the DQA1*0102, DQB1*0602 haplotype whereas this was only present in 26/30 patients, suggesting that the primary association is with HLA-DR and not -DQ. We also found a significant increase in HLA-DR4 (16/53 [30%] in patients compared with 7/55 [13%] in controls;
p
c=0.05). This study contributes a new point on the immunogenetic map of multiple sclerosis in Europe, confirming the primary DR15 association with multiple sclerosis in a previously unstudied population but again highlighting the importance of DR4 in Mediterranean peoples.</description><subject>Alleles</subject><subject>Atlantic Islands</subject><subject>Canary Islands</subject><subject>Gene Frequency - genetics</subject><subject>Genetic Variation - genetics</subject><subject>Genotype</subject><subject>Haplotypes - genetics</subject><subject>HLA</subject><subject>HLA-DQ Antigens - analysis</subject><subject>HLA-DQ Antigens - genetics</subject><subject>HLA-DR Antigens - analysis</subject><subject>HLA-DR Antigens - genetics</subject><subject>Humans</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - immunology</subject><subject>Phenotype</subject><subject>Reference Values</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEUhYMotVZ_QmFWoovRZJLMJBulFLWFggt1HfK4QyPzqJMZxX9v-qBbNzdwz0lOzofQlOA7gkl-_xYHT3mRiRspbjHGBUv5CRoTUWSpYBk5ReOj5RxdhPCJMeGUyREaybzAgrMxelisZokOobVe975tQvLj-3VSD1XvNxUkwVbQtcGHxDdJv4Zkrhvd_SbLUOnGhUt0VuoqwNXhnKCP56f3-SJdvb4s57NVahmjfZoLqbPMEckcFwbLosQGiLHCcC6sM7rMqaGSYVcayzlzOYl7SjNgpMwM0Am63r-76dqvAUKvah8sVPET0A5BiVhNUMr_NZKcSkGkjEa-N9pYL3RQqk3n61hNEay2gNUOsNrSU1KoHWC1DZgeAgZTgzveOhCN-uNeh4jj20OngvXQWHC-A9sr1_p_Ev4A9NWJ_A</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>Coraddu, F</creator><creator>Reyes-Yanez, M.P</creator><creator>Parra, A</creator><creator>Gray, J</creator><creator>Smith, S.I</creator><creator>Taylor, C.J</creator><creator>Compston, D.A.S</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980701</creationdate><title>HLA associations with multiple sclerosis in the Canary Islands</title><author>Coraddu, F ; Reyes-Yanez, M.P ; Parra, A ; Gray, J ; Smith, S.I ; Taylor, C.J ; Compston, D.A.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-689a22d194d58b097f0be1bc8b558cdbaf63b3940dfbc554d6158c332e41f2be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Alleles</topic><topic>Atlantic Islands</topic><topic>Canary Islands</topic><topic>Gene Frequency - genetics</topic><topic>Genetic Variation - genetics</topic><topic>Genotype</topic><topic>Haplotypes - genetics</topic><topic>HLA</topic><topic>HLA-DQ Antigens - analysis</topic><topic>HLA-DQ Antigens - genetics</topic><topic>HLA-DR Antigens - analysis</topic><topic>HLA-DR Antigens - genetics</topic><topic>Humans</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - immunology</topic><topic>Phenotype</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coraddu, F</creatorcontrib><creatorcontrib>Reyes-Yanez, M.P</creatorcontrib><creatorcontrib>Parra, A</creatorcontrib><creatorcontrib>Gray, J</creatorcontrib><creatorcontrib>Smith, S.I</creatorcontrib><creatorcontrib>Taylor, C.J</creatorcontrib><creatorcontrib>Compston, D.A.S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coraddu, F</au><au>Reyes-Yanez, M.P</au><au>Parra, A</au><au>Gray, J</au><au>Smith, S.I</au><au>Taylor, C.J</au><au>Compston, D.A.S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA associations with multiple sclerosis in the Canary Islands</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>87</volume><issue>1</issue><spage>130</spage><epage>135</epage><pages>130-135</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>The study of small island populations has proved informative with respect to the epidemiology and genetics of many complex traits including multiple sclerosis. The class II major histocompatibility antigen DR15 is associated with multiple sclerosis in all groups except Sardinians, where the primary association is with DR4. We compared HLA-DR and -DQ allele frequencies in a representative sample of patients with multiple sclerosis from the Canary Islands with appropriate controls. There was a significant association with DR15 (patients 21/53; 40%: controls 11/55; 20%:
X
2=4.09;
p
c=0.04; relative risk [RR]=1.98). DRB1*1501–DRB5*0101 was present in 17/53 (32%) patients in whom sub-types could be identified compared with 6/55 (11%) controls (
X
2=7.21;
p
c=<0.01; RR=2.94). All DR15 positive controls carried the DQA1*0102, DQB1*0602 haplotype whereas this was only present in 26/30 patients, suggesting that the primary association is with HLA-DR and not -DQ. We also found a significant increase in HLA-DR4 (16/53 [30%] in patients compared with 7/55 [13%] in controls;
p
c=0.05). This study contributes a new point on the immunogenetic map of multiple sclerosis in Europe, confirming the primary DR15 association with multiple sclerosis in a previously unstudied population but again highlighting the importance of DR4 in Mediterranean peoples.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>9670854</pmid><doi>10.1016/S0165-5728(98)00074-5</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-5728 |
| ispartof | Journal of neuroimmunology, 1998-07, Vol.87 (1), p.130-135 |
| issn | 0165-5728 1872-8421 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80018335 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alleles Atlantic Islands Canary Islands Gene Frequency - genetics Genetic Variation - genetics Genotype Haplotypes - genetics HLA HLA-DQ Antigens - analysis HLA-DQ Antigens - genetics HLA-DR Antigens - analysis HLA-DR Antigens - genetics Humans Multiple sclerosis Multiple Sclerosis - immunology Phenotype Reference Values |
| title | HLA associations with multiple sclerosis in the Canary Islands |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T13%3A09%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=HLA%20associations%20with%20multiple%20sclerosis%20in%20the%20Canary%20Islands&rft.jtitle=Journal%20of%20neuroimmunology&rft.au=Coraddu,%20F&rft.date=1998-07-01&rft.volume=87&rft.issue=1&rft.spage=130&rft.epage=135&rft.pages=130-135&rft.issn=0165-5728&rft.eissn=1872-8421&rft_id=info:doi/10.1016/S0165-5728(98)00074-5&rft_dat=%3Cproquest_cross%3E80018335%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16398199&rft_id=info:pmid/9670854&rft_els_id=S0165572898000745&rfr_iscdi=true |