The Role of GM1 Ganglioside in Regulating Excitatory Opioid Effects

Our studies with cultured cells have provided new insight into the particular role of GM1 in regulating excitatory opioid responses. GM1 is significantly elevated in chronic opioid-treated cells via Gs/adenylyl cyclase activation. Such GM1 elevation promotes coupling of opioid receptor with Gs, resu...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 1998-06, Vol.845 (1), p.126-138
Hauptverfasser:	WU, G., LU, Z.-H., WEI, T. J., HOWELLS, R. D., CHRISTOFFERS, K., LEDEEN, R. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Animals G(M1) Ganglioside - pharmacology G(M1) Ganglioside - physiology GTP-Binding Proteins - metabolism Humans Narcotics - pharmacology Neuroblastoma Neurons - drug effects Neurons - physiology Receptors, Opioid - drug effects Receptors, Opioid - physiology Receptors, Opioid, delta - drug effects Receptors, Opioid, delta - physiology Signal Transduction Transfection Tumor Cells, Cultured
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