Function of the Plasminogen/Plasmin and Matrix Metalloproteinase Systems After Vascular Injury in Mice With Targeted Inactivation of Fibrinolytic System Genes

The matrix metalloproteinase (MMP) system, which may be activated via the plasminogen (Plg)/plasmin system, is claimed to play a role in matrix degradation and smooth muscle cell migration. To test the role of both systems, expression of fibrinolytic and gelatinolytic activity was quantified after v...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 1998-07, Vol.18 (7), p.1035-1045
Hauptverfasser:	Lijnen, H. Roger, Van Hoef, Berthe, Lupu, Florea, Moons, Lieve, Carmeliet, Peter, Collen, Desire
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood and lymphatic vessels Blood Vessels - enzymology Blood Vessels - injuries Cardiology. Vascular system Carotid Arteries - enzymology Carotid Artery Injuries Collagenases - analysis Collagenases - metabolism Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Femoral Artery - enzymology Femoral Artery - injuries Fibrinolysin - metabolism Fibrinolysis - genetics Gelatinases - analysis Gelatinases - metabolism Humans Immunohistochemistry Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Medical sciences Metalloendopeptidases - analysis Metalloendopeptidases - metabolism Mice Plasminogen - metabolism Tissue Plasminogen Activator - metabolism Urokinase-Type Plasminogen Activator - metabolism
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