N-Phenylamidines as Selective Inhibitors of Human Neuronal Nitric Oxide Synthase: Structure−Activity Studies and Demonstration of in Vivo Activity

Selective inhibition of the neuronal isoform of nitric oxide synthase (NOS) compared to the endothelial and inducible isoforms may be required for treatment of neurological disorders caused by excessive production of nitric oxide. Recently, we described N-(3-(aminomethyl)benzyl)acetamidine (13) as a...

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Veröffentlicht in:	Journal of medicinal chemistry 1998-07, Vol.41 (15), p.2858-2871
Hauptverfasser:	Collins, Jon L, Shearer, Barry G, Oplinger, Jeffrey A, Lee, Shuliang, Garvey, Edward P, Salter, Mark, Duffy, Claire, Burnette, Thimysta C, Furfine, Eric S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidines - chemical synthesis Amidines - chemistry Amidines - pharmacology Animals Biological and medical sciences Cerebellum - drug effects Cerebellum - enzymology Cerebral Cortex - cytology Cerebral Cortex - drug effects Cerebral Cortex - enzymology Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Furans - chemical synthesis Furans - chemistry Furans - pharmacology Humans Immunomodulators In Vitro Techniques Isoenzymes - antagonists & inhibitors Male Medical sciences Neurons - drug effects Neurons - enzymology Nitric Oxide Synthase - antagonists & inhibitors Pharmacology. Drug treatments Rats Rats, Wistar Structure-Activity Relationship
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