A murine model for B-cell lymphomagenesis in immunocompromised hosts : c-myc-rearranged B-cell lines with a premalignant phenotype

Activation of c-myc or bcl-2 protooncogene is a common event in B-cell lymphomagenesis. Alone, each is insufficient to produce lymphoma, prompting the search for the additional steps required to complete the malignant phenotype. Among the existing systems of murine or human B-cell neoplasia, no comm...

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