A ceramide analog inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis

The ceramide analogue 1-phenyl-2-(decanoylamino)-3-morpholino-1-propanol (PDMP) (particularly the D-threo isomer, D-PDMP) caused inhibition of cell growth in some types of cells, and this growth-inhibitory effect has been attributed to inhibition of UDP-Glc:Cer beta-Glc transferase, resulting in red...

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Veröffentlicht in:	Biochemistry (Easton) 1990-07, Vol.29 (26), p.6314-6322
Hauptverfasser:	Felding-Habermann, Brunhilde, Igarashi, Yasuyuki, Fenderson, Bruce A, Park, Linda S, Radin, Norman S, Inokuchi, Jinichi, Strassmann, Gideon, Handa, Kazuko, Hakomori, Senitiroh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Division - drug effects Ceramides - analysis DNA Replication - drug effects Fundamental and applied biological sciences. Psychology Fundamental immunology Gangliosides - analysis Glycosphingolipids - biosynthesis Immunobiology Interleukin-2 - metabolism Lymphocyte Activation - drug effects Mice Mice, Inbred C3H Modulation of the immune response (stimulation, suppression) Morpholines - pharmacology Phytohemagglutinins - pharmacology Protein-Tyrosine Kinases - metabolism Receptors, Interleukin-2 - analysis Signal Transduction - drug effects Sphingosine - analogs & derivatives Sphingosine - metabolism Stereoisomerism T-Lymphocytes, Cytotoxic - drug effects
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