Primary synovial chondromatosis: A clinicopathologic review and assessment of malignant potential
This is a clinicopathologic review of 53 cases of primary synovial chondromatosis covering a period of 30 years. The average age at presentation was 41 years (range, 17 to 64 years) with a male/female preponderance of 1.8: 1. The condition was always monarticular, the most common site being the knee...
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| Veröffentlicht in: | Human pathology 1998-07, Vol.29 (7), p.683-688 |
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| creator | Davis, R.I Hamilton, A Biggart, J.D |
| description | This is a clinicopathologic review of 53 cases of primary synovial chondromatosis covering a period of 30 years. The average age at presentation was 41 years (range, 17 to 64 years) with a male/female preponderance of 1.8: 1. The condition was always monarticular, the most common site being the knee joint (70%) followed by the hip (20%). Degenerative joint disease was well established in three patients (5%), all occurring in the hip. Nine patients suffered recurrences (15%), including three that became malignant. There was no relationship between the age and site of the lesion, nor between the degree of cellularity of the cartilage and age or site. However, there was an association between cellularity of the cartilage and the extent of calcification and ossification—highly cellular lesions were poorly calcified and ossified, but heavily calcified lesions were usually of relatively low cellularity. There was no relationship between extent of calcification and ossification and the age of the patient. Three patients suffered malignant change representing a relative risk of 5%, much higher than that quoted in other series. This suggests that primary synovial chondromatosis has a significant potential for malignant change. |
| doi_str_mv | 10.1016/S0046-8177(98)90276-3 |
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The average age at presentation was 41 years (range, 17 to 64 years) with a male/female preponderance of 1.8: 1. The condition was always monarticular, the most common site being the knee joint (70%) followed by the hip (20%). Degenerative joint disease was well established in three patients (5%), all occurring in the hip. Nine patients suffered recurrences (15%), including three that became malignant. There was no relationship between the age and site of the lesion, nor between the degree of cellularity of the cartilage and age or site. However, there was an association between cellularity of the cartilage and the extent of calcification and ossification—highly cellular lesions were poorly calcified and ossified, but heavily calcified lesions were usually of relatively low cellularity. There was no relationship between extent of calcification and ossification and the age of the patient. Three patients suffered malignant change representing a relative risk of 5%, much higher than that quoted in other series. This suggests that primary synovial chondromatosis has a significant potential for malignant change.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/S0046-8177(98)90276-3</identifier><identifier>PMID: 9670824</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aneuploidy ; Biological and medical sciences ; Bone Neoplasms - genetics ; Bone Neoplasms - pathology ; Cell Transformation, Neoplastic ; cellularity ; chondrocytes ; Chondromatosis, Synovial - diagnostic imaging ; Chondromatosis, Synovial - pathology ; Chondromatosis, Synovial - surgery ; Chondrosarcoma - genetics ; Chondrosarcoma - pathology ; Diseases of the osteoarticular system ; Fatal Outcome ; Female ; Flow Cytometry ; Humans ; Joint Loose Bodies - diagnostic imaging ; Joint Loose Bodies - pathology ; Joint Loose Bodies - surgery ; Knee Joint - diagnostic imaging ; Knee Joint - pathology ; Male ; malignant transformation ; Medical sciences ; Middle Aged ; Precancerous Conditions - diagnostic imaging ; Precancerous Conditions - pathology ; Precancerous Conditions - surgery ; Radiography ; Retrospective Studies ; synovial chondromatosis ; Tumors of striated muscle and skeleton</subject><ispartof>Human pathology, 1998-07, Vol.29 (7), p.683-688</ispartof><rights>1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-66ce0e4c0f227d1c40b30220e26a948b5dd5feeb9b6b98989a5dd79613b2d3ae3</citedby><cites>FETCH-LOGICAL-c455t-66ce0e4c0f227d1c40b30220e26a948b5dd5feeb9b6b98989a5dd79613b2d3ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0046-8177(98)90276-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2356989$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9670824$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Davis, R.I</creatorcontrib><creatorcontrib>Hamilton, A</creatorcontrib><creatorcontrib>Biggart, J.D</creatorcontrib><title>Primary synovial chondromatosis: A clinicopathologic review and assessment of malignant potential</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>This is a clinicopathologic review of 53 cases of primary synovial chondromatosis covering a period of 30 years. The average age at presentation was 41 years (range, 17 to 64 years) with a male/female preponderance of 1.8: 1. The condition was always monarticular, the most common site being the knee joint (70%) followed by the hip (20%). Degenerative joint disease was well established in three patients (5%), all occurring in the hip. Nine patients suffered recurrences (15%), including three that became malignant. There was no relationship between the age and site of the lesion, nor between the degree of cellularity of the cartilage and age or site. However, there was an association between cellularity of the cartilage and the extent of calcification and ossification—highly cellular lesions were poorly calcified and ossified, but heavily calcified lesions were usually of relatively low cellularity. There was no relationship between extent of calcification and ossification and the age of the patient. Three patients suffered malignant change representing a relative risk of 5%, much higher than that quoted in other series. This suggests that primary synovial chondromatosis has a significant potential for malignant change.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aneuploidy</subject><subject>Biological and medical sciences</subject><subject>Bone Neoplasms - genetics</subject><subject>Bone Neoplasms - pathology</subject><subject>Cell Transformation, Neoplastic</subject><subject>cellularity</subject><subject>chondrocytes</subject><subject>Chondromatosis, Synovial - diagnostic imaging</subject><subject>Chondromatosis, Synovial - pathology</subject><subject>Chondromatosis, Synovial - surgery</subject><subject>Chondrosarcoma - genetics</subject><subject>Chondrosarcoma - pathology</subject><subject>Diseases of the osteoarticular system</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Joint Loose Bodies - diagnostic imaging</subject><subject>Joint Loose Bodies - pathology</subject><subject>Joint Loose Bodies - surgery</subject><subject>Knee Joint - diagnostic imaging</subject><subject>Knee Joint - pathology</subject><subject>Male</subject><subject>malignant transformation</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Precancerous Conditions - diagnostic imaging</subject><subject>Precancerous Conditions - pathology</subject><subject>Precancerous Conditions - surgery</subject><subject>Radiography</subject><subject>Retrospective Studies</subject><subject>synovial chondromatosis</subject><subject>Tumors of striated muscle and skeleton</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtrFTEUgIMo9bb6EwpZiNjFaB6TTOJGSvEFBQV1HTLJmTYyk1xz5lb67017L3crWYSc851HPkLOOXvLGdfvfjDW687wYXhjzYVlYtCdfEI2XEnRGWnFU7I5Is_JKeJvxjhXvTohJ1YPzIh-Q_z3mhZf7yne53KX_EzDbcmxlsWvBRO-p5c0zCmnULZ-vS1zuUmBVrhL8Jf6HKlHBMQF8krLRBc_p5vs22Nb1hZrDV-QZ5OfEV4e7jPy69PHn1dfuutvn79eXV53oVdq7bQOwKAPbBJiiDz0bJRMCAZCe9ubUcWoJoDRjnq0ph3fIoPVXI4iSg_yjLze993W8mcHuLolYYB59hnKDp1pvxfW9A1UezDUglhhctu9A8eZe1DrHtW6B2_OGveo1slWd34YsBsXiMeqg8uWf3XIewx-nqrPIeERE1LptnbDPuwxaDKaxuowJMgBYqoQVhdL-s8i_wDMNpe5</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>Davis, R.I</creator><creator>Hamilton, A</creator><creator>Biggart, J.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980701</creationdate><title>Primary synovial chondromatosis: A clinicopathologic review and assessment of malignant potential</title><author>Davis, R.I ; Hamilton, A ; Biggart, J.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-66ce0e4c0f227d1c40b30220e26a948b5dd5feeb9b6b98989a5dd79613b2d3ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aneuploidy</topic><topic>Biological and medical sciences</topic><topic>Bone Neoplasms - genetics</topic><topic>Bone Neoplasms - pathology</topic><topic>Cell Transformation, Neoplastic</topic><topic>cellularity</topic><topic>chondrocytes</topic><topic>Chondromatosis, Synovial - diagnostic imaging</topic><topic>Chondromatosis, Synovial - pathology</topic><topic>Chondromatosis, Synovial - surgery</topic><topic>Chondrosarcoma - genetics</topic><topic>Chondrosarcoma - pathology</topic><topic>Diseases of the osteoarticular system</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Joint Loose Bodies - diagnostic imaging</topic><topic>Joint Loose Bodies - pathology</topic><topic>Joint Loose Bodies - surgery</topic><topic>Knee Joint - diagnostic imaging</topic><topic>Knee Joint - pathology</topic><topic>Male</topic><topic>malignant transformation</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Precancerous Conditions - diagnostic imaging</topic><topic>Precancerous Conditions - pathology</topic><topic>Precancerous Conditions - surgery</topic><topic>Radiography</topic><topic>Retrospective Studies</topic><topic>synovial chondromatosis</topic><topic>Tumors of striated muscle and skeleton</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davis, R.I</creatorcontrib><creatorcontrib>Hamilton, A</creatorcontrib><creatorcontrib>Biggart, J.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davis, R.I</au><au>Hamilton, A</au><au>Biggart, J.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary synovial chondromatosis: A clinicopathologic review and assessment of malignant potential</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>29</volume><issue>7</issue><spage>683</spage><epage>688</epage><pages>683-688</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>This is a clinicopathologic review of 53 cases of primary synovial chondromatosis covering a period of 30 years. The average age at presentation was 41 years (range, 17 to 64 years) with a male/female preponderance of 1.8: 1. The condition was always monarticular, the most common site being the knee joint (70%) followed by the hip (20%). Degenerative joint disease was well established in three patients (5%), all occurring in the hip. Nine patients suffered recurrences (15%), including three that became malignant. There was no relationship between the age and site of the lesion, nor between the degree of cellularity of the cartilage and age or site. However, there was an association between cellularity of the cartilage and the extent of calcification and ossification—highly cellular lesions were poorly calcified and ossified, but heavily calcified lesions were usually of relatively low cellularity. There was no relationship between extent of calcification and ossification and the age of the patient. Three patients suffered malignant change representing a relative risk of 5%, much higher than that quoted in other series. This suggests that primary synovial chondromatosis has a significant potential for malignant change.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9670824</pmid><doi>10.1016/S0046-8177(98)90276-3</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Aneuploidy Biological and medical sciences Bone Neoplasms - genetics Bone Neoplasms - pathology Cell Transformation, Neoplastic cellularity chondrocytes Chondromatosis, Synovial - diagnostic imaging Chondromatosis, Synovial - pathology Chondromatosis, Synovial - surgery Chondrosarcoma - genetics Chondrosarcoma - pathology Diseases of the osteoarticular system Fatal Outcome Female Flow Cytometry Humans Joint Loose Bodies - diagnostic imaging Joint Loose Bodies - pathology Joint Loose Bodies - surgery Knee Joint - diagnostic imaging Knee Joint - pathology Male malignant transformation Medical sciences Middle Aged Precancerous Conditions - diagnostic imaging Precancerous Conditions - pathology Precancerous Conditions - surgery Radiography Retrospective Studies synovial chondromatosis Tumors of striated muscle and skeleton |
| title | Primary synovial chondromatosis: A clinicopathologic review and assessment of malignant potential |
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