Acceleration of Diabetes in Young NOD Mice with a CD4$^+$ Islet-Specific T Cell Clone

Nonobese diabetic (NOD) mice develop an autoimmune form of diabetes, becoming hyperglycemic after 3 months of age. This process was accelerated by injecting young NOD mice with CD4$^+$ islet-specific T cell clones derived from NOD mice. Overt diabetes developed in 10 of 19 experimental animals by 7...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1990-09, Vol.249 (4975), p.1433-1436
Hauptverfasser:	Haskins, Kathryn, McDuffie, Marcia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Autoimmune diseases Biological and medical sciences CD4 Antigens - analysis CD4 Antigens - immunology Clone Cells Diabetes Diabetes complications Diabetes mellitus Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - pathology Diabetes research Endocrine pancreas. Apud cells (diseases) Endocrine system diseases Endocrinopathies Female Hyperglycemia Islets of Langerhans - immunology Islets of Langerhans - pathology Male Medical sciences Mice Mice, Inbred Strains Mice, Mutant Strains Pancreatic diseases T cells T lymphocytes T-Lymphocytes - immunology T-Lymphocytes - transplantation Type 1 diabetes mellitus
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