Acceleration of Diabetes in Young NOD Mice with a CD4$^+$ Islet-Specific T Cell Clone
Nonobese diabetic (NOD) mice develop an autoimmune form of diabetes, becoming hyperglycemic after 3 months of age. This process was accelerated by injecting young NOD mice with CD4$^+$ islet-specific T cell clones derived from NOD mice. Overt diabetes developed in 10 of 19 experimental animals by 7...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1990-09, Vol.249 (4975), p.1433-1436 |
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| creator | Haskins, Kathryn McDuffie, Marcia |
| description | Nonobese diabetic (NOD) mice develop an autoimmune form of diabetes, becoming hyperglycemic after 3 months of age. This process was accelerated by injecting young NOD mice with CD4$^+$ islet-specific T cell clones derived from NOD mice. Overt diabetes developed in 10 of 19 experimental animals by 7 weeks of age, with the remaining mice showing marked signs of the disease in progress. Control mice did not become diabetic and had no significant pancreatic infiltration. This work demonstrates that a CD4 T cell clone is sufficient to initiate the disease process in the diabetes-prone NOD mouse. |
| doi_str_mv | 10.1126/science.2205920 |
| format | Article |
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This process was accelerated by injecting young NOD mice with CD4$^+$ islet-specific T cell clones derived from NOD mice. Overt diabetes developed in 10 of 19 experimental animals by 7 weeks of age, with the remaining mice showing marked signs of the disease in progress. Control mice did not become diabetic and had no significant pancreatic infiltration. This work demonstrates that a CD4 T cell clone is sufficient to initiate the disease process in the diabetes-prone NOD mouse.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.2205920</identifier><identifier>PMID: 2205920</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Animals ; Antigens ; Autoimmune diseases ; Biological and medical sciences ; CD4 Antigens - analysis ; CD4 Antigens - immunology ; Clone Cells ; Diabetes ; Diabetes complications ; Diabetes mellitus ; Diabetes Mellitus, Experimental - immunology ; Diabetes Mellitus, Experimental - pathology ; Diabetes research ; Endocrine pancreas. Apud cells (diseases) ; Endocrine system diseases ; Endocrinopathies ; Female ; Hyperglycemia ; Islets of Langerhans - immunology ; Islets of Langerhans - pathology ; Male ; Medical sciences ; Mice ; Mice, Inbred Strains ; Mice, Mutant Strains ; Pancreatic diseases ; T cells ; T lymphocytes ; T-Lymphocytes - immunology ; T-Lymphocytes - transplantation ; Type 1 diabetes mellitus</subject><ispartof>Science (American Association for the Advancement of Science), 1990-09, Vol.249 (4975), p.1433-1436</ispartof><rights>Copyright 1990 American Association for the Advancement of Science</rights><rights>1991 INIST-CNRS</rights><rights>COPYRIGHT 1990 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1990 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Sep 21, 1990</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c638t-b26dc39b9c491e106055c463bb1063880633be2363dedc9dd9304aba1f5a11c23</citedby><cites>FETCH-LOGICAL-c638t-b26dc39b9c491e106055c463bb1063880633be2363dedc9dd9304aba1f5a11c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2878194$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2878194$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19495413$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2205920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haskins, Kathryn</creatorcontrib><creatorcontrib>McDuffie, Marcia</creatorcontrib><title>Acceleration of Diabetes in Young NOD Mice with a CD4$^+$ Islet-Specific T Cell Clone</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Nonobese diabetic (NOD) mice develop an autoimmune form of diabetes, becoming hyperglycemic after 3 months of age. This process was accelerated by injecting young NOD mice with CD4$^+$ islet-specific T cell clones derived from NOD mice. Overt diabetes developed in 10 of 19 experimental animals by 7 weeks of age, with the remaining mice showing marked signs of the disease in progress. Control mice did not become diabetic and had no significant pancreatic infiltration. This work demonstrates that a CD4 T cell clone is sufficient to initiate the disease process in the diabetes-prone NOD mouse.</description><subject>Animals</subject><subject>Antigens</subject><subject>Autoimmune diseases</subject><subject>Biological and medical sciences</subject><subject>CD4 Antigens - analysis</subject><subject>CD4 Antigens - immunology</subject><subject>Clone Cells</subject><subject>Diabetes</subject><subject>Diabetes complications</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - immunology</subject><subject>Diabetes Mellitus, Experimental - pathology</subject><subject>Diabetes research</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrine system diseases</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Hyperglycemia</subject><subject>Islets of Langerhans - immunology</subject><subject>Islets of Langerhans - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Mice, Mutant Strains</subject><subject>Pancreatic diseases</subject><subject>T cells</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - transplantation</subject><subject>Type 1 diabetes mellitus</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0kFv0zAUAGALgUYZnLmAZKEBh5LNjpPMPpYUSqWyHrYhccFynJfiyo1L7Aj493hqRAfqobIUP-V9forzHkLPKTmnNC0uvDbQajhPU5KLlDxAI0pEnsSQPUQjQliRcHKZP0ZPvF8TEnOCnaCTgY_Q7URrsNCpYFyLXYOnRlUQwGPT4q-ub1f4ajnFn40G_NOE71jhcpqdfRuf4bm3EJLrLWjTGI1vcAnW4tK6Fp6iR42yHp4N-ym6_fjhpvyULJazeTlZJLpgPCRVWtSaiUroTFCgpCB5rrOCVVWMGefxwSpIWcFqqLWoa8FIpipFm1xRqlN2it7s6m4796MHH-TG-Hgfq1pwvZecEJryjEb46j-4dn3Xxm-TKWV5xjIqIhrv0EpZkKZtXOiUXkEbf8_drRoTX0-44BmhPOp3B3RcNWyMPsDf_sOjCPArrFTvvZxfXx0rl1-Ole9nR0o-W9yX40NSO2thBTK2r1ze1xc7rTvnfQeN3HZmo7rfkhJ5N6ByGFA5TFw88XLoRF9toP7r9_nXQ155rWzTqVYbvy8rMpHHhkb3YufWPrhuX4Zf8mjYHx6o8HE</recordid><startdate>19900921</startdate><enddate>19900921</enddate><creator>Haskins, Kathryn</creator><creator>McDuffie, Marcia</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19900921</creationdate><title>Acceleration of Diabetes in Young NOD Mice with a CD4$^+$ Islet-Specific T Cell Clone</title><author>Haskins, Kathryn ; McDuffie, Marcia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c638t-b26dc39b9c491e106055c463bb1063880633be2363dedc9dd9304aba1f5a11c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Autoimmune diseases</topic><topic>Biological and medical sciences</topic><topic>CD4 Antigens - analysis</topic><topic>CD4 Antigens - immunology</topic><topic>Clone Cells</topic><topic>Diabetes</topic><topic>Diabetes complications</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - immunology</topic><topic>Diabetes Mellitus, Experimental - pathology</topic><topic>Diabetes research</topic><topic>Endocrine pancreas. 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Science)</jtitle><addtitle>Science</addtitle><date>1990-09-21</date><risdate>1990</risdate><volume>249</volume><issue>4975</issue><spage>1433</spage><epage>1436</epage><pages>1433-1436</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Nonobese diabetic (NOD) mice develop an autoimmune form of diabetes, becoming hyperglycemic after 3 months of age. This process was accelerated by injecting young NOD mice with CD4$^+$ islet-specific T cell clones derived from NOD mice. Overt diabetes developed in 10 of 19 experimental animals by 7 weeks of age, with the remaining mice showing marked signs of the disease in progress. Control mice did not become diabetic and had no significant pancreatic infiltration. This work demonstrates that a CD4 T cell clone is sufficient to initiate the disease process in the diabetes-prone NOD mouse.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>2205920</pmid><doi>10.1126/science.2205920</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1990-09, Vol.249 (4975), p.1433-1436 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80012841 |
| source | Jstor Complete Legacy; MEDLINE; Science Magazine |
| subjects | Animals Antigens Autoimmune diseases Biological and medical sciences CD4 Antigens - analysis CD4 Antigens - immunology Clone Cells Diabetes Diabetes complications Diabetes mellitus Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - pathology Diabetes research Endocrine pancreas. Apud cells (diseases) Endocrine system diseases Endocrinopathies Female Hyperglycemia Islets of Langerhans - immunology Islets of Langerhans - pathology Male Medical sciences Mice Mice, Inbred Strains Mice, Mutant Strains Pancreatic diseases T cells T lymphocytes T-Lymphocytes - immunology T-Lymphocytes - transplantation Type 1 diabetes mellitus |
| title | Acceleration of Diabetes in Young NOD Mice with a CD4$^+$ Islet-Specific T Cell Clone |
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