A CASE REPORT OF CUSHING SYNDROME DUE TO THREE DISTINCT ADENOMAS OF RIGHT ADRENAL
A case is presented of a 40 y. o. female with Cushing's syndrome. Her plasma glucocorticoid values were elevated (11-deoxy-cortisol: 3.46ng/ml, cortisol: 25.6μg/dl and cortisone: 35.7ng/ml) with loss of diurnal variation. Urine 17-OHCS value failed to b suppressed by high dose dexamethasone and...
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| Veröffentlicht in: | Nippon Hinyokika Gakkai zasshi 1990/06/20, Vol.81(6), pp.909-912 |
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| container_issue | 6 |
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| container_title | Nippon Hinyokika Gakkai zasshi |
| container_volume | 81 |
| creator | Kaneko, Hisashi Ishigouoka, Manabu Watanabe, Hiroyuki Hirano, Junji Kawamura, Syunzou |
| description | A case is presented of a 40 y. o. female with Cushing's syndrome. Her plasma glucocorticoid values were elevated (11-deoxy-cortisol: 3.46ng/ml, cortisol: 25.6μg/dl and cortisone: 35.7ng/ml) with loss of diurnal variation. Urine 17-OHCS value failed to b suppressed by high dose dexamethasone and was unchanged after metyrapone administration. Her plasma mineralcorticoids and androgens were within normal limits. There were 3 separate tumors in the right adrenal on CT and the left adrenal had no uptake on 131I-adosterol scintigram. We, therefore, diagnosed her illness as Cushing's syndrome due to unilateal multiple adenomas. Gross and histological examination of the right adrenal revealed one compact cell dominant adenoma and two clear cell dominant adenomas. This is the 4th case of Cushing syndrome due to unilateral multiple adrenal adenomas in Japan. |
| doi_str_mv | 10.5980/jpnjurol1989.81.909 |
| format | Article |
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Her plasma glucocorticoid values were elevated (11-deoxy-cortisol: 3.46ng/ml, cortisol: 25.6μg/dl and cortisone: 35.7ng/ml) with loss of diurnal variation. Urine 17-OHCS value failed to b suppressed by high dose dexamethasone and was unchanged after metyrapone administration. Her plasma mineralcorticoids and androgens were within normal limits. There were 3 separate tumors in the right adrenal on CT and the left adrenal had no uptake on 131I-adosterol scintigram. We, therefore, diagnosed her illness as Cushing's syndrome due to unilateal multiple adenomas. Gross and histological examination of the right adrenal revealed one compact cell dominant adenoma and two clear cell dominant adenomas. This is the 4th case of Cushing syndrome due to unilateral multiple adrenal adenomas in Japan.</description><identifier>ISSN: 0021-5287</identifier><identifier>EISSN: 1884-7110</identifier><identifier>DOI: 10.5980/jpnjurol1989.81.909</identifier><identifier>PMID: 2205747</identifier><language>eng ; jpn</language><publisher>Japan: THE JAPANESE UROLOGICAL ASSOCIATION</publisher><subject>Adenoma - complications ; Adenoma - diagnosis ; Adenoma - pathology ; Adrenal Gland Neoplasms - complications ; Adrenal Gland Neoplasms - diagnosis ; Adrenal Gland Neoplasms - pathology ; Adrenal Glands - diagnostic imaging ; Adult ; Cushing Syndrome - etiology ; Cushing's syndrome ; Female ; Humans ; Iodine Radioisotopes ; Neoplasms, Multiple Primary ; Radionuclide Imaging ; Tomography, X-Ray Computed ; unilateral multiple adrenal adenomas</subject><ispartof>The Japanese Journal of Urology, 1990/06/20, Vol.81(6), pp.909-912</ispartof><rights>Japanese Urological Association</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2205747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaneko, Hisashi</creatorcontrib><creatorcontrib>Ishigouoka, Manabu</creatorcontrib><creatorcontrib>Watanabe, Hiroyuki</creatorcontrib><creatorcontrib>Hirano, Junji</creatorcontrib><creatorcontrib>Kawamura, Syunzou</creatorcontrib><title>A CASE REPORT OF CUSHING SYNDROME DUE TO THREE DISTINCT ADENOMAS OF RIGHT ADRENAL</title><title>Nippon Hinyokika Gakkai zasshi</title><addtitle>Jpn. j. urol</addtitle><description>A case is presented of a 40 y. o. female with Cushing's syndrome. Her plasma glucocorticoid values were elevated (11-deoxy-cortisol: 3.46ng/ml, cortisol: 25.6μg/dl and cortisone: 35.7ng/ml) with loss of diurnal variation. Urine 17-OHCS value failed to b suppressed by high dose dexamethasone and was unchanged after metyrapone administration. Her plasma mineralcorticoids and androgens were within normal limits. There were 3 separate tumors in the right adrenal on CT and the left adrenal had no uptake on 131I-adosterol scintigram. We, therefore, diagnosed her illness as Cushing's syndrome due to unilateal multiple adenomas. Gross and histological examination of the right adrenal revealed one compact cell dominant adenoma and two clear cell dominant adenomas. This is the 4th case of Cushing syndrome due to unilateral multiple adrenal adenomas in Japan.</description><subject>Adenoma - complications</subject><subject>Adenoma - diagnosis</subject><subject>Adenoma - pathology</subject><subject>Adrenal Gland Neoplasms - complications</subject><subject>Adrenal Gland Neoplasms - diagnosis</subject><subject>Adrenal Gland Neoplasms - pathology</subject><subject>Adrenal Glands - diagnostic imaging</subject><subject>Adult</subject><subject>Cushing Syndrome - etiology</subject><subject>Cushing's syndrome</subject><subject>Female</subject><subject>Humans</subject><subject>Iodine Radioisotopes</subject><subject>Neoplasms, Multiple Primary</subject><subject>Radionuclide Imaging</subject><subject>Tomography, X-Ray Computed</subject><subject>unilateral multiple adrenal adenomas</subject><issn>0021-5287</issn><issn>1884-7110</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkEtrg0AUhYfS0oY0v6AUZtWd6TzUGZdiTBQSbdUsuhrGcWwTzKNOXPTfV0kIhW7ucOec83E5ADxhNHU8jl63x_22aw8N9rg35XjqIe8GjDDntsUwRrdghBDBlkM4ewATYzYlophxwim9B_eEIIfZbATefRj4eQiz8C3NCpjOYbDOozhZwPwjmWXpKoSzdQiLFBZRFvZLnBdxEhTQn4VJuvLzIZLFi2j4ycLEXz6Cu1o2Rk8u7xis52ERRNYyXcSBv7QUYY5nSVbZFHFXaVcqm2FeUU2plqjWGCni2DWpiGtjSkrESl65LnZUf772SlZxbdMxeDlzj-3hu9PmJHYbo3TTyL0-dEZwhDAhfDDSs1G1B2NaXYtju9nJ9kdgJIYuxd8uBcei77JPPV_wXbnT1TVzaa7Xo7O-NSf5qa-6bE8b1eh_TPc8evTVor5kK_Se_gLbB4Oa</recordid><startdate>199006</startdate><enddate>199006</enddate><creator>Kaneko, Hisashi</creator><creator>Ishigouoka, Manabu</creator><creator>Watanabe, Hiroyuki</creator><creator>Hirano, Junji</creator><creator>Kawamura, Syunzou</creator><general>THE JAPANESE UROLOGICAL ASSOCIATION</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199006</creationdate><title>A CASE REPORT OF CUSHING SYNDROME DUE TO THREE DISTINCT ADENOMAS OF RIGHT ADRENAL</title><author>Kaneko, Hisashi ; Ishigouoka, Manabu ; Watanabe, Hiroyuki ; Hirano, Junji ; Kawamura, Syunzou</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2759-a7d43086ce6ac4718d3e33ea0fe10c254f2d264132b07b8d6615c828e9b7d8e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>1990</creationdate><topic>Adenoma - complications</topic><topic>Adenoma - diagnosis</topic><topic>Adenoma - pathology</topic><topic>Adrenal Gland Neoplasms - complications</topic><topic>Adrenal Gland Neoplasms - diagnosis</topic><topic>Adrenal Gland Neoplasms - pathology</topic><topic>Adrenal Glands - diagnostic imaging</topic><topic>Adult</topic><topic>Cushing Syndrome - etiology</topic><topic>Cushing's syndrome</topic><topic>Female</topic><topic>Humans</topic><topic>Iodine Radioisotopes</topic><topic>Neoplasms, Multiple Primary</topic><topic>Radionuclide Imaging</topic><topic>Tomography, X-Ray Computed</topic><topic>unilateral multiple adrenal adenomas</topic><toplevel>online_resources</toplevel><creatorcontrib>Kaneko, Hisashi</creatorcontrib><creatorcontrib>Ishigouoka, Manabu</creatorcontrib><creatorcontrib>Watanabe, Hiroyuki</creatorcontrib><creatorcontrib>Hirano, Junji</creatorcontrib><creatorcontrib>Kawamura, Syunzou</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nippon Hinyokika Gakkai zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaneko, Hisashi</au><au>Ishigouoka, Manabu</au><au>Watanabe, Hiroyuki</au><au>Hirano, Junji</au><au>Kawamura, Syunzou</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A CASE REPORT OF CUSHING SYNDROME DUE TO THREE DISTINCT ADENOMAS OF RIGHT ADRENAL</atitle><jtitle>Nippon Hinyokika Gakkai zasshi</jtitle><addtitle>Jpn. j. urol</addtitle><date>1990-06</date><risdate>1990</risdate><volume>81</volume><issue>6</issue><spage>909</spage><epage>912</epage><pages>909-912</pages><issn>0021-5287</issn><eissn>1884-7110</eissn><abstract>A case is presented of a 40 y. o. female with Cushing's syndrome. Her plasma glucocorticoid values were elevated (11-deoxy-cortisol: 3.46ng/ml, cortisol: 25.6μg/dl and cortisone: 35.7ng/ml) with loss of diurnal variation. Urine 17-OHCS value failed to b suppressed by high dose dexamethasone and was unchanged after metyrapone administration. Her plasma mineralcorticoids and androgens were within normal limits. There were 3 separate tumors in the right adrenal on CT and the left adrenal had no uptake on 131I-adosterol scintigram. We, therefore, diagnosed her illness as Cushing's syndrome due to unilateal multiple adenomas. Gross and histological examination of the right adrenal revealed one compact cell dominant adenoma and two clear cell dominant adenomas. This is the 4th case of Cushing syndrome due to unilateral multiple adrenal adenomas in Japan.</abstract><cop>Japan</cop><pub>THE JAPANESE UROLOGICAL ASSOCIATION</pub><pmid>2205747</pmid><doi>10.5980/jpnjurol1989.81.909</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0021-5287 |
| ispartof | The Japanese Journal of Urology, 1990/06/20, Vol.81(6), pp.909-912 |
| issn | 0021-5287 1884-7110 |
| language | eng ; jpn |
| recordid | cdi_proquest_miscellaneous_80012284 |
| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adenoma - complications Adenoma - diagnosis Adenoma - pathology Adrenal Gland Neoplasms - complications Adrenal Gland Neoplasms - diagnosis Adrenal Gland Neoplasms - pathology Adrenal Glands - diagnostic imaging Adult Cushing Syndrome - etiology Cushing's syndrome Female Humans Iodine Radioisotopes Neoplasms, Multiple Primary Radionuclide Imaging Tomography, X-Ray Computed unilateral multiple adrenal adenomas |
| title | A CASE REPORT OF CUSHING SYNDROME DUE TO THREE DISTINCT ADENOMAS OF RIGHT ADRENAL |
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