Somatic Instability of the CTG Repeat in Mice Transgenic for the Myotonic Dystrophy Region is Age Dependent But Not Correlated to the Relative Intertissue Transcription Levels and Proliferative Capacities

A (CTG)n expansion in the 3′-untranslated region (UTR) of the DM protein kinase gene (DMPK) is responsible for causing myotonic dystrophy (DM). Major instability, with very large expansions between generations and high levels of somatic mosaicism, is observed in patients. There is a good correlation...

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