Immunohistochemistry of thyroid carcinoma--an experience with thyroglobulin and calcitonin
A retrospective immunohistochemical study of 33 cases of primary thyroid carcinomas and 5 cases of metastases to thyroid was carried out. The immunostaining for thyroglobulin and calcitonin was done by peroxidase-anti-peroxidase (PAP) technique. The optimum staining results were obtained by proper s...
Gespeichert in:
| Veröffentlicht in: | Indian journal of pathology & microbiology 1998-04, Vol.41 (2), p.163-167 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 167 |
|---|---|
| container_issue | 2 |
| container_start_page | 163 |
| container_title | Indian journal of pathology & microbiology |
| container_volume | 41 |
| creator | Kavishwar, V S Phatak, A M Rege, J D |
| description | A retrospective immunohistochemical study of 33 cases of primary thyroid carcinomas and 5 cases of metastases to thyroid was carried out. The immunostaining for thyroglobulin and calcitonin was done by peroxidase-anti-peroxidase (PAP) technique. The optimum staining results were obtained by proper standardisation of the staining procedure and reagents. The sections were systematically evaluated for immunostaining intensity and distribution. The observations revealed that thyroglobulin and calcitonin could be useful as sensitive and specific histogenetic markers for follicular and parafollicular cell derived thyroid carcinomas respectively. However, there was no absolute correlation between thyroglobulin positivity and grade of differentiation. The immunostaining could not differentiate follicular adenoma from follicular carcinoma. More extensive study using other markers may be useful for better patient management. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_80011560</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80011560</sourcerecordid><originalsourceid>FETCH-LOGICAL-p121t-fac7d55c25603f3579146e0ecd260d663db68e037cd89a38ea4c7d18c2b2a7593</originalsourceid><addsrcrecordid>eNotkDtPwzAYRT2ASgn8BKRMbJH8iO1kRBWPSpW6wMISOfYXYuTYwXEE_fekaqa7nHuke6_QFjMpi7Km9Q26naZvjEVJOdugTS0kFrTaos_9MMw-9HZKQfcwLBlPeejy1J9isCbXKmrrw6CKQvkc_kaIFryG_Nem_kJ9udDOzvpc-TPvtE3BW3-HrjvlJrhfM0MfL8_vu7ficHzd754OxUgoSUWntDSca8oFZh3jsialAAzaUIGNEMy0ooJliTZVrVgFqlwKpNK0pUrymmXo8eIdY_iZYUrNskKDc8pDmKemwpiQszxDDys4twOYZox2UPHUrGewf5guXCo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80011560</pqid></control><display><type>article</type><title>Immunohistochemistry of thyroid carcinoma--an experience with thyroglobulin and calcitonin</title><source>MEDLINE</source><source>EZB Electronic Journals Library</source><creator>Kavishwar, V S ; Phatak, A M ; Rege, J D</creator><creatorcontrib>Kavishwar, V S ; Phatak, A M ; Rege, J D</creatorcontrib><description>A retrospective immunohistochemical study of 33 cases of primary thyroid carcinomas and 5 cases of metastases to thyroid was carried out. The immunostaining for thyroglobulin and calcitonin was done by peroxidase-anti-peroxidase (PAP) technique. The optimum staining results were obtained by proper standardisation of the staining procedure and reagents. The sections were systematically evaluated for immunostaining intensity and distribution. The observations revealed that thyroglobulin and calcitonin could be useful as sensitive and specific histogenetic markers for follicular and parafollicular cell derived thyroid carcinomas respectively. However, there was no absolute correlation between thyroglobulin positivity and grade of differentiation. The immunostaining could not differentiate follicular adenoma from follicular carcinoma. More extensive study using other markers may be useful for better patient management.</description><identifier>ISSN: 0377-4929</identifier><identifier>PMID: 9670628</identifier><language>eng</language><publisher>India</publisher><subject>Adenocarcinoma, Follicular - chemistry ; Adenoma - chemistry ; Biomarkers, Tumor - analysis ; Calcitonin - analysis ; Carcinoma - chemistry ; Carcinoma, Papillary - chemistry ; Female ; Humans ; Immunohistochemistry - methods ; Male ; Retrospective Studies ; Thyroglobulin - analysis ; Thyroid Neoplasms - chemistry</subject><ispartof>Indian journal of pathology & microbiology, 1998-04, Vol.41 (2), p.163-167</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9670628$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kavishwar, V S</creatorcontrib><creatorcontrib>Phatak, A M</creatorcontrib><creatorcontrib>Rege, J D</creatorcontrib><title>Immunohistochemistry of thyroid carcinoma--an experience with thyroglobulin and calcitonin</title><title>Indian journal of pathology & microbiology</title><addtitle>Indian J Pathol Microbiol</addtitle><description>A retrospective immunohistochemical study of 33 cases of primary thyroid carcinomas and 5 cases of metastases to thyroid was carried out. The immunostaining for thyroglobulin and calcitonin was done by peroxidase-anti-peroxidase (PAP) technique. The optimum staining results were obtained by proper standardisation of the staining procedure and reagents. The sections were systematically evaluated for immunostaining intensity and distribution. The observations revealed that thyroglobulin and calcitonin could be useful as sensitive and specific histogenetic markers for follicular and parafollicular cell derived thyroid carcinomas respectively. However, there was no absolute correlation between thyroglobulin positivity and grade of differentiation. The immunostaining could not differentiate follicular adenoma from follicular carcinoma. More extensive study using other markers may be useful for better patient management.</description><subject>Adenocarcinoma, Follicular - chemistry</subject><subject>Adenoma - chemistry</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Calcitonin - analysis</subject><subject>Carcinoma - chemistry</subject><subject>Carcinoma, Papillary - chemistry</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>Male</subject><subject>Retrospective Studies</subject><subject>Thyroglobulin - analysis</subject><subject>Thyroid Neoplasms - chemistry</subject><issn>0377-4929</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkDtPwzAYRT2ASgn8BKRMbJH8iO1kRBWPSpW6wMISOfYXYuTYwXEE_fekaqa7nHuke6_QFjMpi7Km9Q26naZvjEVJOdugTS0kFrTaos_9MMw-9HZKQfcwLBlPeejy1J9isCbXKmrrw6CKQvkc_kaIFryG_Nem_kJ9udDOzvpc-TPvtE3BW3-HrjvlJrhfM0MfL8_vu7ficHzd754OxUgoSUWntDSca8oFZh3jsialAAzaUIGNEMy0ooJliTZVrVgFqlwKpNK0pUrymmXo8eIdY_iZYUrNskKDc8pDmKemwpiQszxDDys4twOYZox2UPHUrGewf5guXCo</recordid><startdate>199804</startdate><enddate>199804</enddate><creator>Kavishwar, V S</creator><creator>Phatak, A M</creator><creator>Rege, J D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199804</creationdate><title>Immunohistochemistry of thyroid carcinoma--an experience with thyroglobulin and calcitonin</title><author>Kavishwar, V S ; Phatak, A M ; Rege, J D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p121t-fac7d55c25603f3579146e0ecd260d663db68e037cd89a38ea4c7d18c2b2a7593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adenocarcinoma, Follicular - chemistry</topic><topic>Adenoma - chemistry</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Calcitonin - analysis</topic><topic>Carcinoma - chemistry</topic><topic>Carcinoma, Papillary - chemistry</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>Male</topic><topic>Retrospective Studies</topic><topic>Thyroglobulin - analysis</topic><topic>Thyroid Neoplasms - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kavishwar, V S</creatorcontrib><creatorcontrib>Phatak, A M</creatorcontrib><creatorcontrib>Rege, J D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Indian journal of pathology & microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kavishwar, V S</au><au>Phatak, A M</au><au>Rege, J D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemistry of thyroid carcinoma--an experience with thyroglobulin and calcitonin</atitle><jtitle>Indian journal of pathology & microbiology</jtitle><addtitle>Indian J Pathol Microbiol</addtitle><date>1998-04</date><risdate>1998</risdate><volume>41</volume><issue>2</issue><spage>163</spage><epage>167</epage><pages>163-167</pages><issn>0377-4929</issn><abstract>A retrospective immunohistochemical study of 33 cases of primary thyroid carcinomas and 5 cases of metastases to thyroid was carried out. The immunostaining for thyroglobulin and calcitonin was done by peroxidase-anti-peroxidase (PAP) technique. The optimum staining results were obtained by proper standardisation of the staining procedure and reagents. The sections were systematically evaluated for immunostaining intensity and distribution. The observations revealed that thyroglobulin and calcitonin could be useful as sensitive and specific histogenetic markers for follicular and parafollicular cell derived thyroid carcinomas respectively. However, there was no absolute correlation between thyroglobulin positivity and grade of differentiation. The immunostaining could not differentiate follicular adenoma from follicular carcinoma. More extensive study using other markers may be useful for better patient management.</abstract><cop>India</cop><pmid>9670628</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0377-4929 |
| ispartof | Indian journal of pathology & microbiology, 1998-04, Vol.41 (2), p.163-167 |
| issn | 0377-4929 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80011560 |
| source | MEDLINE; EZB Electronic Journals Library |
| subjects | Adenocarcinoma, Follicular - chemistry Adenoma - chemistry Biomarkers, Tumor - analysis Calcitonin - analysis Carcinoma - chemistry Carcinoma, Papillary - chemistry Female Humans Immunohistochemistry - methods Male Retrospective Studies Thyroglobulin - analysis Thyroid Neoplasms - chemistry |
| title | Immunohistochemistry of thyroid carcinoma--an experience with thyroglobulin and calcitonin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T07%3A20%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immunohistochemistry%20of%20thyroid%20carcinoma--an%20experience%20with%20thyroglobulin%20and%20calcitonin&rft.jtitle=Indian%20journal%20of%20pathology%20&%20microbiology&rft.au=Kavishwar,%20V%20S&rft.date=1998-04&rft.volume=41&rft.issue=2&rft.spage=163&rft.epage=167&rft.pages=163-167&rft.issn=0377-4929&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E80011560%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80011560&rft_id=info:pmid/9670628&rfr_iscdi=true |